Nightmares and abnormal dreams may be the rare side effects of metformin. Studies are needed to confirm the association and causality of these findings.
Nightmares are reported in patients receiving metformin. [7] However, they are less frequent than insomnia. [8] Indeed, the cerebral blood glucose is known for its relationship to dreaming[9,10] and the change of its level after intake of metformin might be the underlying pathogenesis of nightmares.
Metformin is an oral medication used to treat type 2 diabetes that is generally well tolerated. GI upset, especially diarrhea, is the most common side effect. This typically decreases over time. Although rare, lactic acidosis, hypoglycemia, and vitamin B12 deficiency can occur.
Metformin (200 mg/kg/day, oral administration for 8 weeks) improve learning and memory ability, neurological dysfunction and oxidative stress, and reduced Aβ levels and increased the expression of synaptic-related genes [194]. Metformin activates AMPK signaling pathway and upregulates the insulin-degrading enzyme.
Metformin may have an adverse effect on renal function in patients with type 2 DM and moderate CKD.
As much as possible, avoid white bread, white rice, white pasta, candy, soda, desserts, and snacks like chips or crackers. Eating foods that can spike your blood sugar will not necessarily make the metformin not work, however, it will increase the burden it has to work against.
If you eat a lot of sugar while taking Metformin, your body will have to work harder to keep your blood sugar levels within a healthy range, and the Metformin will not be as effective for weight loss. However, if it happens infrequently, you should not suffer too many negative side effects. The key is moderation.
Everyone has vivid dreams occasionally. Any number of things, from pregnancy to stress, can contribute to vivid dreams. Substance misuse, medication side effects, or even an underlying sleep disorder may play a role. In most cases, vivid dreams will go away on their own.
Excessive dreaming is usually attributed to sleep fragmentation and the consequent ability to remember dreams due to the successive awakenings. The dreams usually have no particular character, but sometimes they might include situations associated with drowning or suffocation.
Vitamin B6 Deficiency
Vitamin B6 actually affects our subconscious as much as our conscious self by having an impact on how we dream.
Blood sugar fluctuations are a hallmark symptom of diabetes. They're also one of the most common causes of interrupted sleep. “Low sugar can cause vivid dreams or nightmares. It can also cause restless sleep and sweating,” says Romy Block, MD, a board-certified specialist in endocrine and metabolism medicine.
How to take it. It's best to take metformin tablets with, or just after, your evening meal to reduce the chance of getting side effects. Swallow your metformin tablets whole with a drink of water.
Metformin side effects can include diarrhea, nausea and vomiting, and gas. Taking metformin on a schedule can help reduce side effects. Most metformin side effects are short-term, which is 2 weeks or less. See a healthcare provider if you're experiencing long-term metformin side effects.
More serious side effects are rare. They include severe allergic reactions and a condition called lactic acidosis, a buildup of lactic acid in the bloodstream. The risk for this is higher among people with significant kidney disease, so doctors tend to avoid prescribing metformin for them.
Sulfonylureas or SFUs [DiaBeta, Glynase, or Micronase (glyburide or glibenclamide) Amaryl (glimepiride) Diabinese (chlorpropamide) Glucotrol (glipizide)] Usage: This is a good alternative to metformin and works well to lower blood sugar levels.
If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the ...
Metformin with insulin: At first, 500 mg a day. Your doctor may increase your dose by 500 mg every week if needed until your blood sugar is controlled. However, the dose is usually not more than 2500 mg per day.
Metformin has two advantages over other diabetes drugs: There's less risk of your blood sugar level falling too low. It doesn't cause weight gain.
Thus, metformin is capable of accelerating the oxidation of fat in the liver, thereby leading to a decrease of visceral fat or body weight.
The use of metformin by non-diabetics stems from some evidence that metformin can decrease inflammation, protect against cardiovascular disease and cognitive impairment, minimize cancer risk and progression, and prolong life.
Even in studies that indicated weight loss, the results were modest. One of the most extensive studies to date, performed by the Diabetes Prevention Program (DPP), tested metformin in people with prediabetes (those at risk for developing T2D). People randomly assigned metformin lost an average of 4-7 pounds.