Approximately 30% of patients with type 2 diabetes mellitus (T2D) have hypomagnesemia (blood magnesium (Mg2+) concentration <0.7 mmol/L). In T2D patients, treatment with metformin is associated with reduced blood Mg2+ levels.
Magnesium and metformin, when taken together, can lead to hypoglycemia (low blood sugar levels). This is because both work to lower blood sugar and the combined effect could lead to dizziness, palpitations, feeling sweaty, etc.
metformin can commonly reduce vitamin B12 levels in patients, which may lead to vitamin B12 deficiency. the risk of low vitamin B12 levels increases with higher metformin dose, longer treatment duration, and in patients with risk factors for vitamin B12 deficiency.
Type 2 diabetes is frequently associated with both extracellular and intracellular magnesium (Mg) deficits. A chronic latent Mg deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles.
As a cofactor for enzymatic activities in glycolysis and insulin regulation, magnesium plays a vital role in protecting against and reversing type 2 diabetes.
Metformin can cause serum vitamin B12 deficiency, but studies on the influence of its duration and dose are lacking. We investigated vitamin B12 deficiency in patients with type 2 diabetes using metformin, in conjunction with other related factors.
Some supplements may interfere with how well your diabetes medications work, such as St. John's wort and ginseng. Others, like niacin, might also change the way your body responds to insulin.
Avocados: One whole avocado = 58 mg of magnesium. Bananas: One medium banana = 32 mg of magnesium. Papaya: One small papaya = 33 mg of magnesium. Blackberries: 1 cup = 29 mg of magnesium.
People with diabetes, intestinal disease, heart disease or kidney disease should not take magnesium before speaking with their health care provider. Overdose. Signs of a magnesium overdose can include nausea, diarrhea, low blood pressure, muscle weakness, and fatigue. At very high doses, magnesium can be fatal.
Magnesium deficiency in healthy people is rare but it can be caused by: a poor diet (especially in elderly people or those who don't have enough to eat) type 2 diabetes. digestive problems such as Crohn's disease.
Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.
Metformin may have an adverse effect on renal function in patients with type 2 DM and moderate CKD.
If your diabetes remains hard to manage even after you begin taking metformin, or you cannot tolerate metformin or do not want to take it, that's when a GLP-1RA or SGLT2i might come in. Studies have shown that both medications are safe and effective at lowering blood glucose when compared to a placebo.
Recently, researchers have found that vitamin D and magnesium play different roles in diabetes; thus, a combination of adequate vitamin D and magnesium is most likely required to enhance insulin secretion and action and promote glycemic control.
Bananas may be best known for being rich in heart-healthy and bone-strengthening potassium, but a medium-size banana also provides 32 mg of magnesium, in addition to 10.3 mg of vitamin C (a good source) and 3 g (a good source) of fiber, according to the USDA.