Since it was first identified, schizophrenia has been recognized as a degenerative disease. However, the progression to structural brain damage is not inevitable, and can be arrested with expeditious, decisive treatment.
So although schizophrenia has no cure and sometimes may get worse over time, the right medications, combined with therapy, can help control the symptoms.
Brain changes can happen in people whose psychosis goes untreated. "The more relapses and episodes a person has, the more we see that it can permanently change their brain function and structure," says Tso.
Schizophrenia is a complex brain disorder. It often runs in families and can cause troubling symptoms. It's caused by a chemical imbalance and other changes in the brain. Symptoms include hearing voices, feeling that people are out to get you, and having false beliefs that are not based in reality.
Schizophrenia treatment includes medication, therapy, social and family support, and the use of social services. Treatment must be ongoing, as this is a chronic illness without a cure. When schizophrenia is treated and managed over the long-term, most people can live normal, productive, and fulfilling lives.
According to the World Health Organization (WHO), the decline in life expectancy among people with more severe mental illness ranges from 10–25 years . Most studies of schizophrenia show a life expectancy reduction of 10–20 years.
Left untreated, schizophrenia can result in severe problems that affect every area of life. Complications that schizophrenia may cause or be associated with include: Suicide, suicide attempts and thoughts of suicide. Anxiety disorders and obsessive-compulsive disorder (OCD)
Can a brain scan show schizophrenia? It is not currently possible to determine that a person has schizophrenia simply by looking at a brain scan, but certain changes in the brain that can be observed on a brain scan have been associated with schizophrenia.
Schizophrenia has been described as the “worst disease” to afflict mankind. It causes psychosis, which is an abnormal state of mind marked by hyperarousal, overactivation of brain circuits, and emotional distress. An untreated episode of psychosis can result in structural brain damage due to neurotoxicity.
Although studies on volumetric magnetic resonance imaging (MRI) analysis in schizophrenia have shown relatively consistent results over several decades (7), diagnosing schizophrenia based on these findings is still challenging and has little clinical utility.
Schizophrenia does not typically get better as you get older. The symptoms of schizophrenia may become worse over time, or they may remain the same for some people. Schizophrenia is a chronic illness that can be managed with medication and therapy, but it does not typically go away as you get older.
The prognosis of schizophrenia is varied at the individual level. In general it has great human and economics costs. It results in a decreased life expectancy of 12–15 years primarily due to its association with obesity, little exercise, and smoking, while an increased rate of suicide plays a lesser role.
Despite the stability of cognitive functioning, the clinical presentation of schizophrenia may vary over the course of the illness. The symptoms and functioning in some persons with schizophrenia will worsen over time, and many will remain stable. Some, however, will improve.
Like many of the mental issues we treat, schizophrenia never truly goes away in the sense that we have a cure for it. The good news is that individuals diagnosed as schizophrenic have gone on to live successful, productive lives after seeking treatment.
Unfortunately, most people with schizophrenia are unaware that their symptoms are warning signs of a mental disorder. Their lives may be unraveling, yet they may believe that their experiences are normal. Or they may feel that they're blessed or cursed with special insights that others can't see.
At least one third of people with schizophrenia experiences complete remission of symptoms (1). Some people with schizophrenia experience worsening and remission of symptoms periodically throughout their lives, others a gradual worsening of symptoms over time.
Potential long-term effects of schizophrenia
Destroyed relationships with family and friends. Social isolation. Addiction. Significant health problems due to poor self-care and an inability to follow medical advice.
Researchers have long hypothesized that memory problems in schizophrenia stem from disruptions in the brain's dorsolateral prefrontal cortex (DLPFC). This area of the brain plays a key role in working memory--the system for temporarily storing and managing information required to carry out complex cognitive tasks.
During the last several decades, evidence has accumulated that schizophrenia is associated with significant impairment in cognitive functioning. Specifically, deficits in attention, memory, and executive function have been consistently reported in patients with schizophrenia (1–3).
While there is no known cure, it is possible to live a meaningful and happy life with schizophrenia. There are many effective treatments, best provided by a team. These include medication, psychotherapy, behavioral therapy, and social services, as well as tools to help you stay in school or keep working.
In a large clinical study, 60 percent of patients with schizophrenia (subtype 1) had decreased gray matter volumes throughout the brain compared to healthy people, which is the typical pattern seen in those with this disorder.
“Type I” (positive) schizophrenia was characterized by hallucinations, delusions, and formal thought disorder, with a presumed underlying dopaminergic dysfunction, while patients with “Type II” (negative) schizophrenia displayed social withdrawal, loss of volition, affective flattening, and poverty of speech, presumed ...
Most people with schizophrenia are harmless to others. They're more likely to hurt themselves than anybody else. Sometimes that includes trying to take their own life. You should take any suicidal talk seriously, and pay attention to poems, notes, or any other things your loved one creates that are about death.
(January 2022) Schizophrenia is a chronic and severe brain disorder that interferes with a person's ability to think clearly, manage emotions, make decisions and relate to others. Although it affects barely 1% of the population, it is one of the most disabling diseases affecting humankind.
Schizophrenia is typically diagnosed in the late teens years to early thirties, and tends to emerge earlier in males (late adolescence – early twenties) than females (early twenties – early thirties). More subtle changes in cognition and social relationships may precede the actual diagnosis, often by years.