This medication is generally well tolerated in most pets. Side effects are rare and may include: Vomiting. Lethargy.
Additionally, the chemicals in some flea treatments can be irritating to dogs, leading to discomfort and restlessness. Finally, some dogs may experience an allergic reaction to the ingredients in flea medicine, which can also lead to restlessness.
Side Effects & Warnings
Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures.
Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. The FDA considers this level to be “very rare”. The isoxazoline class of drugs acts at receptors in the central nervous system of invertebrates like fleas and ticks.
Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures.
Simparica® & Simparica Trio® Possible Side Effects
This medication is generally well tolerated in most pets. Side effects are rare and may include: Vomiting. Lethargy.
Lethargy can sometimes be described as extreme tiredness, although it isn't quite the same. A lethargic dog is not interested in his/her normal day-to-day life and is either unable or unwilling to get up out of bed very often.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
How long does Simparica protection last? Simparica is a monthly chewable that starts protecting in hours* and lasts for 35 days.
Adverse reactions in dogs treated with SIMPARICA TRIO included diarrhea and vomiting. For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1‑888‑963‑8471.
But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks. Hence, Simparica would be the bigger bet, but Nexgard is just as effective. So before you opt for any oral treatment, consult your vet first.
Clinical signs include: A tingling sensation; dogs will excessively itch or scratch that spot on their skin. Scratching, intense itchiness. Agitation or restlessness.
The odd behavior could be a survival instinct or a medical condition. Malabsorption diseases are also common causes of the dog's strange behavior.
How quickly does Simparica work? Simparica kills fleas within 3 hours of administration, with 100% effectiveness against adult fleas within 8 hours. Simparica maintains 100% effectiveness against weely infestations for 35 days.
Use with caution in dogs with a history of seizures or neurologic disorders. Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms.
Cedar oil is a good replacement for flea medications for dogs like Bravecto Chews for Dogs, Frontline Plus for Dogs, Revolution for Dogs, Simparica for Dogs, Advantage Multi for Dogs, and more.
I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation.
If your dog is lethargic, it may very well be the result of an illness. While lethargy in dogs can be caused by lots of different things, it can also be a sign of a serious illness. If your pet has been lethargic, they should be checked out by a vet immediately to determine if a serious illness is present.
Causes of lethargy
However, some common examples include: Infections - tend to cause a xxx high temperature and lethargy. Obesity - overweight dogs tend to feel lethargic and move around less. Pain - anything that causes pain or discomfort (for example arthritis) is likely to make your dog feel lethargic.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
Since these products have obtained their respective FDA approvals, data received by the agency as part of its routine post-marketing activities indicates that some animals receiving Bravecto, Nexgard or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.