The patients with Sjogren's had an overall lower quality of sleep [8]. All of the studies in the systematic review noted that there is an increased number of nighttime awakenings in Sjogren's patients.
All patients with primary Sjogren's syndrome said they experienced sleep problems, including unrefreshing sleep, night awakenings, difficulty falling asleep, altered circadian rhythm, and nighttime pain and discomfort.
Avoiding foods that tend to exacerbate symptoms including alcohol, caffeine, acidic foods, and spicy foods.
Because your body has trouble producing saliva, you may experience difficulty swallowing when symptoms flare up. Your mouth may feel chalky, and you may have trouble swallowing food. Many people with Sjogren's develop cavities and oral infections.
Global cognitive impairment in Sjögren's
Most patients experience “brain fog” symptoms, which manifest as memory lapses, forgetfulness, mental confusion, and difficulties in concentrating, organizing, or anticipating future events.
These and previous studies suggest a model for pSS that separates the disease into several stages: 1) initial injury to the submandibular and lacrimal glands via an environmental insult and LTα; 2) amplification of local injury via the production of type 1 IFN; injury to the parotid glands, lungs, and kidneys is seen; ...
Doctors typically use steroids to treat flare-ups, when symptoms such as joint pain and rashes come on suddenly. Steroids such as prednisone or methylprednisolone are taken by mouth, and your doctor determines the dosage based on the severity of your symptoms.
Sjogren's Syndrome patients often complain of mental fatigue or “brain fog.” Brain fog impairs focus, causes fuzzy concentration, and contributes to difficulty in problem-solving. Keep your stress levels low, and give your brain a workout with crosswords, puzzles, reading, adult coloring books, or online brain games.
Dry eyes, corneal ulcerations and infections. Dry nose, recurrent sinusitis, nosebleeds. Dry mouth, mouth sores, dental decay, difficulty with chewing, speech, taste and dentures. Swollen, painful parotid/salivary glands.
The neurological complications of Sjögren's syndrome are extensive and range from cognitive difficulties, to burning toes and feet.
While some people experience mild discomfort, others suffer debilitating symptoms that greatly impair their ability to function. Early diagnosis and proper treatment can prevent serious complications and greatly improve quality of life.
Avoid medicines that are known to cause dry eyes. These include antihistamines, diuretics, and some antidepressants. Talk with your doctor if you take any of these medicines. Sometimes the benefits of a medicine outweigh the risks.
Dryness in these organs can lead to irritation, soreness, and pain. Patients with primary Sjogren's syndrome report fatigue as one of the most difficult symptoms they have to cope with.
Sip water or sugarless drinks often. Let small ice chips melt in your mouth. Avoid drinks with caffeine, such as coffee, tea, and some sodas – caffeine can dry out the mouth. Sip water or a sugarless drink during meals.
These medicines are called immunosuppressants. They include methotrexate, mycophenolate mofetil, azathioprine, and cyclophosphamide. These are the most common immunosuppressants used for Sjögren's.
Dazodalibep now is the only therapy in development for Sjögren's that has achieved the Phase 2 primary endpoint in both of these patient populations, according to Horizon. The company plans to work with the U.S. Food and Drug Administration (FDA) to design a Phase 3 clinical program of dazodalibep in Sjögren's.
Overall, there was good adherence to the exercise program, with a mean 72% compliance rate for the complete program. After 16 weeks, the walking program had significantly enhanced the cardiorespiratory fitness of patients in the training group, compared with the control group.
While Sjogren's patients overall experience higher than expected mortality, most can expect to live a normal lifespan.
For Sjögren's patients, an optimal range of humidity is between 55% and 60% regardless of the ambient temperature. You can monitor the humidity in your home with a simple humidistat.
While many patients experience dry eyes, dry mouth, fatigue and joint pain, Sjögren's can also cause dysfunction of organs such as the kidneys, gastrointestinal system, blood vessels, lungs, liver, pancreas, and the central nervous system.
The symptoms can be severe, with some people reporting debilitating pain and fatigue. People with Sjögren's syndrome have a higher chance of developing a type of cancer called lymphoma, but the risk of developing it is low.
Your eyes might burn, itch or feel gritty — as if there's sand in them. Dry mouth. Your mouth might feel like it's full of cotton, making it difficult to swallow or speak.