Deficiency of Vitamin B12 can result in hematological changes, neurological and psychiatric problems, which can manifest as irritability, changes in personality, depression, and memory loss [9].
Vitamin B-12 and other B vitamins play a role in producing brain chemicals that affect mood and other brain functions. Low levels of B-12 and other B vitamins such as vitamin B-6 and folate may be linked to depression.
Vitamin B12 deficiency can have distressing neuropsychiatric symptoms. It can have an etiological role in clinical presentations like depression, anxiety, psychosis, dementia, and delirium, requiring screening of at-risk populations.
B12 acts as a cofactor in synthesis of neurotransmitters such as serotonin and dopamine, thus B12 deficiency affects mood, emotions and sleeping and can lead to psychiatric disorders.
Some of the negative side effects of vitamin B overdose include mood swings, restlessness, depression, and panic attacks. Mood swings can worsen in people who suffer from paranoia, confusion, or mental fogginess; due to the high doses of vitamin B complex.
Key points about vitamin B12 deficiency anemia
Without enough oxygen, your body can't work as well. Symptoms include weak muscles, numbness, trouble walking, nausea, weight loss, irritability, fatigue, and increased heart rate. Treatment may include vitamin B12 supplements.
Once you begin treating your vitamin B12 deficiency, it can take up to six to 12 months to fully recover. It is also common to not experience any improvement during the first few months of treatment. If you can, it's a good idea to address what's causing the deficiency.
Very high daily doses of vitamin B12, ranging between 1000 and 2000 mcg, may effectively restore B12 levels within the body and positively impact depression symptoms. Even doses as low as 100 mcg are potent enough to positively impact cognition in adults with depressive symptoms.
Vitamin B12 helps increase the body's production of melatonin, making it important for regulating sleep-wake cycles. Higher B12 levels have been associated with a lower risk of depression. That makes sense because disruptions in circadian rhythm can be an underlying—and significant—factor for depression.
Nervous System Reactions
After getting a vitamin B12 injection some people may experience a disturbance to the nervous system. These symptoms may include dizziness, difficulty walking normally, nervousness, anxiety, weakness and uncoordinated movements.
If you have any of the following health problems, consult your doctor or pharmacist before using this medication: a certain eye disease (Leber's optic neuropathy), a certain blood disorder (polycythemia vera), gout, iron or folic acid deficiency anemia, low potassium blood levels (hypokalemia).
Excess B12 is either stored in the liver, present in the blood without any adverse effects, or excreted. There are no studies investigating the potential clinical effects of high B12 because, in general, there are no known adverse effects caused by elevated B12.
To see how well your tablets are working, your doctor may ask you about symptoms such as tiredness and lack of energy. You may also have regular blood tests to monitor the levels of vitamin B12 in your blood.
It's harder to get your B12 from food if you're on a strict plant-based diet. That means you don't eat any animal products, including eggs or dairy. Your doctor will likely suggest taking a daily or weekly dietary supplement to keep your levels up.
Diet. Some people can develop a vitamin B12 deficiency as a result of not getting enough vitamin B12 from their diet. A diet that includes meat, fish and dairy products usually provides enough vitamin B12, but people who do not regularly eat these foods can become deficient.
Deficiency of Vitamin B12 can result in hematological changes, neurological and psychiatric problems, which can manifest as irritability, changes in personality, depression, and memory loss [9]. It is also known to worsen depression by excitotoxic reactions caused by the accumulation of homocysteine [10].
Digestive diseases: Diseases that affect the digestive system, like Crohn's disease and celiac disease, can prevent your body from fully absorbing vitamin B12. Surgery: People who have gastrointestinal surgery, such as a gastric bypass (weight loss surgery), can have difficulty absorbing vitamin B12.
According to health experts at Click Pharmacy, as a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
Taking in adequate amounts of Vitamin B12 For Stress can help reduce stress by promoting healthy nervous system function. When the nervous system is functioning properly, the adrenal glands do not secrete as much cortisol—the hormone produced during times of stress that causes “fight or flight” response.
B12 deficiency can also lead to nerve and brain damage. This damage may manifest in symptoms such as brain fog, memory problems, fatigue, depression, muscle fatigue and tingling in the extremities.