How common is failed implantation? Failed embryo implantation is complex and more common than you may think. In a natural pregnancy, it's believed that somewhere between 40 to 60% of embryos are lost during the period between fertilization and birth [3].
Variations to the chromosomes inside the embryo are a major cause of recurrent implantation failure. Chromosomes are special structures, found within cells, that contain DNA.
Of those fertilised eggs, around 15% will be lost before implantation begins. Of those which begin to implant, only about half will implant successfully.
Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant.
When an embryo fails to implant, there can only be two logical reasons: the embryo is not good enough (genetically abnormal), or the endometrium is not “receptive” (doesn't allow the embryo to implant) enough.
The lining of the uterus is receptive to the embryo for only a brief time, called the Window of Implantation. It is possible that a perfectly normal embryo might not implant because the lining was not ready for it. In natural cycles, the window may be 4-5d wide, but in our treatments in can be only 12-48h long.
Mental stress can lead to an increased endogenous level of epinephrine. Excessive epinephrine level may interfere with the decidual differentiation of human endometrial stromal cells and thus affect embryo implantation.
Failed Implantation Symptoms
Generally, when implantation occurs, you may experience sensitive breasts and mild abdominal cramping. If you haven't experienced these in the weeks after your embryo transfer, it may be indicative that the implantation has failed. Additionally, you may experience vaginal bleeding.
What can cause implantation to fail? Unfortunately, various conditions can hamper the proper implantation of a blastocyst. In some cases, genetic disorders in the developing embryo disrupt the trypsin signal and cause a stress reaction that forces the uterus to reject the blastocyst.
In case the blastocyst does not implant, the lining of the uterus (endometrium) makes arrangements for the developing blastocyst to connect to it through many internal changes. Without these changes, implantation will not occur, and the embryo sheds off during menstruation.
The best advice is common sense: eat healthily, avoid cigarette smoke, exercise gently, and try some relaxation techniques. You don't need to confine yourself to bed, but you should go easy on yourself, as you're going through a lot – both physically and emotionally.
The same group showed that increased sperm DNA damage adversely affects embryo quality at all stages of development, resulting in reduced implantation rates (IRs) and pregnancy outcomes (15).
This means the implantation takes place about 7 to 8 days after fertilization of the egg. The time required for implantation in both the cases, normal pregnancy and pregnancy through IVF, is more or less the same.
The causes of implantation failure are diverse and especially due to different maternal factors as uterine abnormalities, hormonal or metabolic disorders, infections, immunological factors, thrombophilias as well as other less common ones.
Emergency contraceptives, like Plan B, are drugs and products used to prevent pregnancy or prevent the implantation of a new pregnancy.
According to the research, sleeping on one's back improves the odds of a successful outcome. It has increased the success rate by 0.014 percent.
During the two-week wait, it's better to err on the side of caution. Avoid having a drink, smoking, or any other activity that could be harmful to a brand new pregnancy. It's fine to continue exercising if you already have a workout routine, but now might not be the time to take up a new, intense form of exercise.
Progesterone is what stabilizes the uterine lining and makes it “sticky” enough for an embryo to attach. Without enough progesterone, it can be more difficult for an embryo to successfully implant. Progesterone stabilizes the uterine lining and makes it “sticky” enough for an embryo to attach.
Conclusions: In most successful human pregnancies, the conceptus implants 8 to 10 days after ovulation.
In general, 3 factors contribute to embryo implantation: embryo quality; endometrial receptivity; and embryo transfer (ET) technique. Of these factors, embryo quality is arguably the most important and perhaps the least well understood at this point in time.
Between one-third and one-half of all fertilized eggs never fully implant. A pregnancy is considered to be established only after implantation is complete.
Once embryos have been frozen, they will remain viable indefinitely. You can choose to begin a frozen embryo transfer after an unsuccessful fresh in vitro fertilization (IVF) cycle if you still wish to start a family.