How do I know if my antidepressant works? When you start taking an antidepressant, you should begin to function better in your daily life before you start feeling better, says Dr. Michael McGee. In other words, you should begin sleeping better, eating better, and having more energy.
Antidepressants help by adjusting the neurochemical signaling in the brain. This change helps to reduce depression, but since these same brain chemicals are related to other mental health conditions, people could find themselves feeling more stress, more anxiety, and more panic from the antidepressant.
You should be able to experience the following benefits while on antidepressants: Improve mood and motivation. Reduce restlessness and promote better sleep. Increase appetite and concentration.
You may feel some depression symptoms improve within the first couple weeks, but it can often take 4 to 8 weeks to feel the full effects of your medication. If you've taken your antidepressant for at least 4 weeks with no improvement, let your healthcare provider know.
Your Mood or Energy Improve Too Much
If you're taking antidepressant medication and you either feel unusually elated, or you become very terse with your loved ones, feel noticeably more irritable, or have an uncharacteristic bout of rage, then it's likely that your antidepressant dose is too high.
Exactly how antidepressants work is still a mystery. The effects are thought to be related to changes in neurochemicals in your brain, such as serotonin, dopamine, and norepinephrine — changes that usually take 2 to 12 weeks to set in, with a peak at 6 to 8 weeks.
Antidepressants don't have the euphoric effects other drugs have. In other words, Antidepressants can't get the user high. That doesn't stop some people from trying, though. Some people think since Antidepressants improve mood that high doses must induce euphoria, but that is not how the drugs work.
1 Day – On the first day of taking an antidepressant medication, most people will feel nothing at all. Some will notice side effects like nausea or vomiting that could be mild. 1 Week – One week in, people are more likely to note some other side effects like sleeping problems, diarrhea, dry mouth, and sexual problems.
Emotional blunting means you are numb to both positive and negative emotions. You can't seem to cry or feel sad about things that normally would make you sad.
About half of users who take selective serotonin reuptake inhibitors (SSRIs) report a sense of emotional blunting, a psychic flatness that limits their emotional range, particularly their ability to experience positive feelings like pleasure and joy.
It's because some antidepressants also numb reward sensations (pleasure) while inhibiting the painful depressive feelings. It's a common side effect of SSRI antidepressants. But really, there's nothing to worry about.
Antidepressants can cause unpleasant side effects. Signs and symptoms such as nausea, weight gain or sleep problems can be common initially. For many people, these improve within weeks of starting an antidepressant. In some cases, however, antidepressants cause side effects that don't go away.
Some antidepressants can also cause feelings of agitation, restlessness and detachment. These feelings may resemble symptoms of anxiety and may add to, rather than relieve, feelings of hopelessness and despair. Some people may become suicidal or violent.
It's thought that antidepressants work by increasing neurotransmitters. These are chemicals in the brain like serotonin and noradrenaline. They can improve mood and emotion, although this process isn't fully understood. Increasing levels of neurotransmitters can also disrupt pain signals sent by nerves.
The Evidence for Personality Changes
Study authors suggested that the SSRI may have altered two key personality traits linked to depression—neuroticism and extroversion—independently of their effect on depression symptoms.
Most antidepressants boost mood and reduce depression symptoms by elevating serotonin levels in the brain. Although this is beneficial for someone who's depressed, for someone who does not have depression, taking antidepressant medication can cause serotonin to build up in the body, resulting in serotonin syndrome.
Antidepressants can make you feel worse at first
Starting an antidepressant can't actually make your depression worse. But it can cause side effects that are very similar to depression. Antidepressants can make you feel tired, cause concentration problems, and lead to changes in sleep and appetite.
Antidepressants are used most often for serious depressions, but they can also be helpful for some milder depressions. Antidepressants are not “uppers” or stimulants, but rather take away or reduce the symptoms of depression and help depressed people feel the way they did before they became depressed.
Some people had taken time off from work to help them cope with their initial reaction to an antidepressant. People typically said they found it difficult to work productively.
SSRIs release two chemicals in the brain that kick in at different times, causing a period of negative effects on mental health, the authors report. The first chemical is serotonin, which is released very soon after an SSRI is taken but might not lessen depressive symptoms until after a couple of weeks.
It's usually recommended that a course of antidepressants continues for at least 6 months after you feel better, to prevent your condition recurring when you stop. Some people with recurrent illness are advised to carry on taking medicine indefinitely.
Around 60% of people respond by about two months to the drugs with about a 50% reduction in their symptoms - an improvement in mood, better sleep and so on. But, he said, “about 80% of people stop antidepressants within a month”.
Most antidepressants take one to two weeks to start working. But you might feel some benefits sooner than this, such as improved sleep. Speak to your doctor if you don't feel any benefit after taking an antidepressant regularly for two to four weeks, or if you feel worse.
Antidepressants were lauded back in the 80s as the miracle cure for major depression, but as more and more clinical trials are revealing, as many as 50% of the patients who were prescribed antidepressants did not experience a successful result—on antidepressants but still depressed.