Take your time. Clinicians generally recommend staying on the medication for six to nine months before considering going off antidepressants. If you've had three or more recurrences of depression, make that at least two years.
You are feeling better, and you and the doctor agree that it is time to stop. You have been taking the medicine for at least 6 months after you feel better. You are having counselling to help you cope with problems and help change how you think and feel. You are not worried about the depression coming back.
Discontinuing an antidepressant medication usually involves reducing your dose in increments, allowing two to six weeks or longer between dose reductions. Your clinician can instruct you in tapering your dose and prescribe the appropriate dosage pills.
It's usually recommended that a course of antidepressants continues for at least 6 months after you feel better, to prevent your condition recurring when you stop.
Can antidepressants cause permanent changes to the brain? Antidepressants can cause changes in neurotransmitter levels and brain function; however, these changes are typically reversible once the medication is stopped.
People taking Paxil and Effexor often have more intense withdrawal symptoms. These drugs have short half-lives and leave the body faster than drugs with long half-lives. The faster an antidepressant leaves the body, the worse the withdrawal symptoms. This is because of the sudden imbalance of chemicals in the brain.
In studies on adults with moderate or severe depression, 40–60% report improvements within 6–8 weeks. Those who wish to come off antidepressants because they feel better should ideally wait for at least 6–9 months after complete symptom remission before stopping their medication.
Many people with depression continue taking antidepressant drugs for months or even years after their symptoms have resolved. This so-called maintenance therapy aims to reduce the risk of relapse. The numbers of people taking maintenance therapy for depression is increasing.
Specifically, weight gain seems to be a common long-term risk, especially the medications that affect serotonin levels. This could be because serotonin is associated with an increase in appetite. There is also a risk of higher blood sugar levels and diabetes with taking antidepressants long-term.
What are the most common antidepressant medications? Sertraline, also known by the brand name Zoloft, used for multiple mental health and mood disorders, is the most prescribed antidepressant dispensed to U.S.
Antidepressant Discontinuation Syndrome (ADS) Timeline
The symptoms typically last 1-3 weeks and will typically peak within the first week.
Meanwhile, patients who benefit from antidepressants may not need to stay on them long term. Some may want to quit because of side effects such as loss of sexual desire or decreased arousal. In other cases, their prescribers may recommend they stop taking the medications.
Antidepressant Withdrawal Timeline
Acute withdrawal: The acute withdrawal phase can last six to eight weeks. 8 During this phase, you may begin to experience flu-like symptoms, have greater fatigue, and notice increased feelings of anxiety and depression.
The most common signs your antidepressant dose is too strong are symptoms of serotonin syndrome. If you become overly elated, tense with your loved ones, or irritated and have mood swings, this indicates that you are taking high antidepressant doses.
Perhaps the fundamental reason why antidepressants are so widely prescribed and used is that they fit with the 'medical model' of mental illness, which has become the standard view in western culture. This model sees depression as a medical condition which can be “fixed” in the same way as a physical injury or illness.
“Even though they say your meds are 'non-habit forming,' you can still have serious, debilitating withdrawals when you try to get off of them, and there's no telling how long they will last.” — Matthew A. 3. “I didn't know antidepressants could affect your libido.
So do antidepressants work as a permanent cure for depression? No, they do not, and the reason for this lies in how they work. While they cause changes in brain chemistry, this effect is only temporary. When you stop taking the antidepressant, your brain chemistry will return to its previous state.
In the case of SSRIs, SNRIs, and related medications, the effects of taking antidepressants when not depressed can include developing a condition known as serotonin syndrome. Symptoms of this condition include the following: Confusion. Agitation.
Medication treatment options for racing thoughts may include: Antidepressants: Many people who take medication for depression report experiencing an increase in motivation, excitement, confidence, and ability to concentrate.
— Bupropion and venlafaxine were ranked #1 and #2 respectively in highest mortality rates among the second-generation ADs; bupropion had the highest morbidity rate. — Among the SSRIs, citalopram was the most dangerous, and in one comparison, it was four times more likely to be fatal than sertraline and escitalopram.
Prozac (fluoxetine) was most commonly linked to aggression, increasing violent behavior 10.9 times. Paxil (paroxetine), Luvox (fluvoxamine), Effexor (venlafaxine) and Pristiq (desvenlafaxine) were 10.3, 8.4, 8.3 and 7.9 times, respectively, more likely to be linked with violence.
The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41).