How fast does zoledronic work?

It takes at least 7 days after a dose to get the full benefit of this drug. The dose may need to be repeated depending on your blood calcium levels. For the treatment of multiple myeloma and bone problems caused by the spread of cancer, this medication is usually given every 3 to 4 weeks or as directed by your doctor.

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How will I feel after zoledronic acid infusion?

Zoledronic acid can cause flu-like symptoms such as joint and muscle pain, fatigue, shivering and fever. These can last for a few days. Your treatment team can advise you about taking mild pain relief to help.

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Does zoledronic acid strengthen bones?

Zoledronate (zoledronic acid) Zoledronate is a drug treatment for osteoporosis. It can help to strengthen bones, making them less likely to break. It is given as an intravenous infusion (IV or 'drip') once a year.

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Does zoledronic acid infusion help bone loss?

Zoledronic acid is one of the bisphosphonate drug treatments which are used to reduce the risk of broken bones in people with osteoporosis. It is given as an intravenous infusion (drip), 5mg once a year, usually in a hospital clinic. The drug is given slowly, typically over 20 minutes via a needle inserted into a vein.

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How long does zoledronic acid infusion stay in the body?

Zoledronic acid medication is a long-acting drug. As such, it stays in your body longer than 12 months (probably more than 24 months). Therefore, delaying your treatment for a number of months will not put you at a higher risk of sustaining fragility fracture nor cause significant decline in your bone mineral density.

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FDA Urges Caution Over Long-Term Use of Bone-Density-Building Drugs

28 related questions found

Is fatigue a side effect of zoledronic acid?

The following side effects are common (occurring in greater than 30%) for patients taking zoledronic acid:
  • Ostealgia.
  • Nausea.
  • Fever usually mild and short lived.
  • Fatigue.
  • Anemia.
  • Vomiting.
  • Constipation.
  • Flu-like symptoms; mild fever sometimes accompanied by malaise, chills, fatigue and flushing.

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Does zoledronic acid cause weight loss?

Both treatment groups lost body weight during the study (placebo 1.65 kg, zoledronate 1.05 kg), and this was significantly greater in the placebo group (P = 0.01). Both groups lost lean mass, and this loss was marginally (0.17 kg) but significantly (P = 0.02) greater in those receiving zoledronate.

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Does Medicare cover zoledronic acid infusion?

Medicare recipients who are prescribed zoledronic acid as an outpatient treatment, Medicare Part B may cover some of the cost of your care and medication. There may be a copay or coinsurance amount that applies, as well as a deductible amount that must be met before costs are covered by Medicare.

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What are the long term side effects of zoledronic acid?

According to a list of zoledronic acid side-effects, dangerous side-effects such as coma, confusion, convulsions, difficult breathing, hypotension, atrial fibrillation, and cardiac arrhythmia secondary to hypocalcemia are possible [16].

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How many zoledronic acid infusions can you have?

If you are having zoledronic acid to help prevent the cancer coming back, you will have an infusion once every 6 months for 3 to 5 years. If you are having zoledronic acid to lower calcium levels in your blood, it is usually given as a single dose.

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Does zoledronic acid cause weight gain?

Tell your doctor if you have serious side effects of Reclast including urinating less than usual or not at all; drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, swelling, weight gain, shortness of breath, muscle spasms, numbness or tingling (especially around your mouth), ...

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Is zoledronic acid a form of chemotherapy?

Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer.

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Can you drink alcohol with zoledronic acid?

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of zoledronic acid. pregnancy. It is best to use birth control while being treated with zoledronic acid. Tell your doctor right away if you or your partner becomes pregnant.

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Does zoledronic acid lower immune system?

3.5. Effects of ZOL on anti-cancer immunity. In addition to its effects on bone cells, ZOL has profound effects on the immune system, including a plethora of immune cell subsets expressing the mevalonate pathway enzymes, leading to a general increase in anti-tumour immunity [65].

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Does zoledronic acid cause anxiety?

Some people report insomnia, anxiety or confusion, coughing, and skeletal pain with zoledronic acid.

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When do you repeat calcium after zoledronic acid?

Recheck calcium level weekly as long as risk of hypercalcaemia remains or more frequently if symptoms dictate. 10. Give further doses of bisphosphonate (zoledronic acid) if calcium levels high and it is more than 3 weeks since the last dose of bisphosphonate.

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How effective is zoledronic acid for osteoporosis?

EFFECTIVENESS. Zoledronic acid has been shown to decrease spine and hip fractures in two studies. It has been studied in women with a mean age of 73 years who are at high risk of fracture (three-year risk of any fracture of 12.8 percent).

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What are the patient reviews of zoledronic acid infusion?

User Reviews for Zoledronic acid to treat Osteoporosis. Zoledronic acid has an average rating of 4.7 out of 10 from a total of 221 reviews for the treatment of Osteoporosis. 32% of reviewers reported a positive experience, while 48% reported a negative experience.

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How often do you get zoledronic acid for osteoporosis?

Zoledronic acid (Aclasta) is given as a once-yearly injection. bisphosphonate treatments that are taken orally as once-daily or once- weekly tablets. with osteoporosis has shown that zoledronic acid (Aclasta) is effective in reducing the risk of hip, spine and other fractures.

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How much is zoledronic acid injection 4mg?

Zoledronic Acid Injection 4mg, Packaging Type: Box, Packaging Size: 1 Vial at Rs 2990/piece in Mumbai.

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Does zoledronic acid infusion affect teeth?

If you are having dental procedures while receiving this medicine, you may have an increased chance of having a severe problem with your jaw. Make sure you tell your doctor or dentist about any new problems, such as pain or swelling, with your teeth or jaw.

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Does zoledronic acid affect the heart?

Zoledronic acid is associated with a 25% increased risk of atrial fibrillation during its first year of use for osteoporosis compared to treatment with denosumab, shows a US study published in Journal of Bone and Mineral Research.

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Does zoledronic acid make arthritis worse?

Musculoskeletal side effects following intravenous zolendronic acid, have also been reported, including the onset of new arthritis, painful joints and flare of existing osteoarthritis (11, 18, 24).

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