How is leukemia diagnosed? A diagnosis of leukemia is usually made by analyzing a patient's blood sample through a complete blood count (CBC) or microscopic evaluation of the blood, or by using flow cytometry.
Laboratory tests, and specifically blood tests, are among the most important diagnostic tools for leukemia. For some types of leukemia, such as chronic lymphocytic leukemia, blood tests may be the only test needed to confirm the diagnosis (but other tests may be used to find out more about the cancer).
Bone marrow test.
The bone marrow is removed using a long, thin needle. The sample is sent to a laboratory to look for leukemia cells. Specialized tests of your leukemia cells may reveal certain characteristics that are used to determine your treatment options.
Common leukemia signs and symptoms include: Fever or chills. Persistent fatigue, weakness. Frequent or severe infections.
Chronic leukemia may go undetected
Unlike acute leukemia, chronic leukemia develops slowly. It may take months or even several years before the disease begins to cause symptoms that alert the patient that something is wrong.
Chronic leukemia involves more-mature blood cells. These blood cells replicate or accumulate more slowly and can function normally for a period of time. Some forms of chronic leukemia initially produce no early symptoms and can go unnoticed or undiagnosed for years.
Many people don't have any symptoms for at least a few years. In time, the cells can spread to other parts of the body, including the lymph nodes, liver, and spleen.
Stage 1 – A patient has high levels of white blood cells and enlarged lymph nodes. Stage 2 – A patient has high levels of white blood cells and is anemic. He or she may also have enlarged lymph nodes. Stage 3 – A patient has high levels of white blood cells and is anemic.
Acute leukemia symptoms can often appear suddenly
With acute leukemia, symptoms tend to develop very quickly. You may suddenly spike a fever that won't go away, develop an infection for no apparent reason, or start bleeding spontaneously from your nose or gums and not be able to stop it.
6. Is leukemia curable if caught early? If caught early, leukemia can be cured by undergoing several cancer treatments.
The most common leukemia biomarkers are CD (cluster of differentiation) markers, an extremely diverse series of membrane proteins predominantly expressed on the leukocyte surface. CD markers are mostly useful for classifying white blood cells (WBC) and especially important for diagnosis of lymphomas and leukemias.
A blood test showing an abnormal white cell count may suggest the diagnosis. To confirm the diagnosis and identify the specific type of leukemia, a needle biopsy and aspiration of bone marrow from a pelvic bone will need to be done to test for leukemic cells, DNA markers, and chromosome changes in the bone marrow.
Leukemia bruises have several distinguishing features that set them apart from normal bruises including: Location: Bruises may appear in places you would normally not have bruising, such as the back, chest, or face. Number: You may have many bruises at once, arising for no apparent reason.
The nature of the discomfort can vary; some patients report sharp pain while others liken it to a dull, continuous ache. What bones hurt with leukemia? Bone pain symptoms tend to develop in areas of the body with bones that contain a large amount of bone marrow, such as the: Breastbone (sternum)
People in stages 0 to II may live for 5 to 20 years without treatment. CLL has a very high incidence rate in people older than 60 years. CLL affects men more than women. If the disease has affected the B cells, the person's life expectancy can range from 10 to 20 years.
In the United States, overall, 5-year survival among people diagnosed with leukemia is 65%. However, these statistics vary greatly according to the specific subtype of disease: Chronic lymphocytic leukemia (CLL) 5-year survival rate is 88%. Acute lymphocytic leukemia (ALL) 5-year survival rate is 71.3%.
The median age of a patient diagnosed with acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) or chronic myeloid leukemia (CML) is 65 years and older. However, most cases of acute lymphocytic leukemia (ALL) occur in people under 20 years old. The median age of an ALL patient at diagnosis is 15.
Leukemia starts in the soft, inner part of the bones (bone marrow), but often moves quickly into the blood. It can then spread to other parts of the body, such as the lymph nodes, spleen, liver, central nervous system and other organs.
Bone marrow biopsy
This is the gold standard investigation to diagnose Leukemia. This invasive procedure is done after the suspicion of Leukemia or when the blood test reports point to a Leukemic picture.
Leukemia is commonly misdiagnosed as the following conditions: Influenza. Fever. Pathological fracture.
Chronic leukemia often causes only a few symptoms or none at all. Signs and symptoms usually develop gradually. People with a chronic leukemia often complain that they just do not feel well. The disease is often found during a routine blood test.
If acute leukemia is left untreated, a person with leukemia becomes increasingly susceptible to fatigue, excessive bleeding and infections until, finally, the body becomes virtually defenseless, making every minor injury or infection very serious. Leukemia may be fatal.