SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg)
SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re‑infestation, it is important to treat all dogs and cats within a household with a flea control product.
How long does Simparica protection last? Simparica is a monthly chewable that starts protecting in hours* and lasts for 35 days. That gives you a little wiggle room at the end of the month, in case you're late with the next month's dose.
For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks.
This small, chewable tablet kills fleas and ticks for up to 35 days to help prevent illnesses in your dog and eliminate and prevent home infestations.
Simparica kills adult fleas so fast they don't get a chance to lay eggs and reproduce. Why can I still see fleas on my dog after giving Simparica? Fleas can live in a variety of areas outside of your home as well as on other dogs that your dog may encounter.
Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8–5.5 pounds.
Simparica Trio provides broad protection against some of the biggest threats to dogs including: Adult fleas. Brown Dog Ticks & Paralysis Ticks. Heartworm.
You can give it at any time of the day and you can give it with or without food. After you give your dog his Simparica chew the ingredient sarolaner travels in your dog's blood and quickly reaches tissue fluids just under your dog's skin.
Simparica contains three active substances: sarolaner, moxidectin and pyrantel. Sarolaner acts as an 'ectoparasiticide'. This means that it kills parasites present on the skin or in the fur of animals, such as fleas and ticks.
If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner. However, if your dog is already taking a flea and tick preventative, your vet might suggest concomitant use of Heartgard Plus.
If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.
If you forget a month of preventative, make sure to give the next 2 doses on time to "catch up" for that missed month. If you miss several months in a row, you should give your vet a call for advice on when to plan for the next heartworm test and how to get started back on preventatives.
If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.
Simparica Trio is a once-a-month chewable that protects your dog with three proven ingredients designed for defense. It's available from your vet with a prescription and comes with a 100% satisfaction guarantee. Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms.
Simparica Trio is a highly effective and convenient medication for preventing flea, tick, and heartworm infestations in dogs. It offers long-lasting protection and is generally safe for most dogs.
Simparica TRIO should be administered at monthly intervals. It can be given year-round or, at minimum, within one month of the dog's first seasonal exposure to mosquitoes and continued until at least one (1) month after the dog's last seasonal exposure to mosquitoes.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval.
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
For those of us that don't always remember to give our preventatives on day 30, Simparica's effects will last until day 35 without tapering off, providing continuous protection. This allows owners a 5 day margin of error should they forget to give their preventatives on time.
Most of the monthly heartworm medicines have a safety factor of at least 15 days of protection if a dose is missed. This means that if you're just a week or two late, your pet is likely still within that window of protection and would be unlikely to become infected during that time.
Signs of heartworm disease may include a mild persistent cough, reluctance to exercise, fatigue after moderate activity, decreased appetite, and weight loss. As heartworm disease progresses, pets may develop heart failure and the appearance of a swollen belly due to excess fluid in the abdomen.
Although there are fewer mosquitoes in the winter, there is still a risk that your pet could get heartworms if you stop giving heartworm prevention medication during this season. That's one reason veterinarians strongly recommend pets receive heartworm prevention medication year-round.
How Often Should I Give This Medicine? You should give Simparica for dogs once a month. The medicine is effective for 35 days. Thus, even if you forget to give this medicine exactly 30 days later, you have a window of 5 days to give another dose.