SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). SIMPARICA TRIO can be offered to the dog with or without food.
SIMPARICA TRIO should be administered year‑round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re‑infestation, it is important to treat all dogs and cats within a household with a flea control product.
For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks.
How long does Simparica protection last? Simparica is a monthly chewable that starts protecting in hours* and lasts for 35 days. That gives you a little wiggle room at the end of the month, in case you're late with the next month's dose.
The dosing schedules are once a month for Nexgard and Simparica and once every three months for Bravecto. These flea treatments are oral medications. The drugs come in a soft chew that your dog can eat like a treat.
If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. Contact your vet if your dog misses a month or more of heartworm prevention—your dog might have become infected with heartworm larvae.
This small, chewable tablet kills fleas and ticks for up to 35 days to help prevent illnesses in your dog and eliminate and prevent home infestations.
If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.
If you forget a month of preventative, make sure to give the next 2 doses on time to "catch up" for that missed month. If you miss several months in a row, you should give your vet a call for advice on when to plan for the next heartworm test and how to get started back on preventatives.
As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
Simparica Trio provides broad protection against some of the biggest threats to dogs including: Adult fleas. Brown Dog Ticks & Paralysis Ticks. Heartworm.
Simparica kills adult fleas so fast they don't get a chance to lay eggs and reproduce. Why can I still see fleas on my dog after giving Simparica? Fleas can live in a variety of areas outside of your home as well as on other dogs that your dog may encounter.
For those of us that don't always remember to give our preventatives on day 30, Simparica's effects will last until day 35 without tapering off, providing continuous protection. This allows owners a 5 day margin of error should they forget to give their preventatives on time.
You can give it at any time of the day and you can give it with or without food. After you give your dog his Simparica chew the ingredient sarolaner travels in your dog's blood and quickly reaches tissue fluids just under your dog's skin.
The laboratory studies demonstrated that Simparica Trio™ is highly effective against the four tick species that commonly infest dogs in Europe within 48 hours of treatment of an existing infestation and within 48 hours of re-infestation for one month following treatment.
If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner. However, if your dog is already taking a flea and tick preventative, your vet might suggest concomitant use of Heartgard Plus.
Most of the monthly heartworm medicines have a safety factor of at least 15 days of protection if a dose is missed. This means that if you're just a week or two late, your pet is likely still within that window of protection and would be unlikely to become infected during that time.
Although there are fewer mosquitoes in the winter, there is still a risk that your pet could get heartworms if you stop giving heartworm prevention medication during this season. That's one reason veterinarians strongly recommend pets receive heartworm prevention medication year-round.
However, due to the heartworm life-cycle, it is likely that giving the medication every 45 to 60 days, rather than every 30 days, will allow immature heartworms to develop into adult heartworms. In other words, heartworm prevention medication is not effective when given every 45 to 60 days.
SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). SIMPARICA TRIO can be offered to the dog with or without food.
The veterinary medicinal product has immediate and persistent flea killing activity against new infestations for 5 weeks; The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Killing Fleas: Simparica
From the moment your dog ingests Simparica Trio, any fleas they may unknowingly be harboring will be killed in four hours. As for Simparica, any adult fleas who thought they had more time to tie up loose ends will be killed in three hours.
For treatment of tick and flea infestations Simparica should be given once every month throughout the flea and/or tick season for optimal control. For treatment of sarcoptic mange, Simparica is given monthly for two consecutive months.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.