GFR generally declines at a rate of 1 mL/min/year.
Glomerular filtration rate is a measure of functional renal mass. Reductions in GFR can occur with primary renal disease, decreased renal perfusion, or obstructive renal disease.
Rapid GFR decline is a recognized predictor of impaired GFR (<60 mL/min/1.73 m2).
Most of these studies have been cross-sectional and have rather uniformly shown that the GFR declines steadily with aging, beginning at age 30–40 years, with an apparent acceleration in the rate of decline after age 65–70 years (6–9).
The estimated glomerular filtration rate (eGFR) is variable and it relies on a blood test, which may have day to day variations and it is an "estimation". Hence, the more times you do the test, the more accurate will be the estimate.
Renal function worsens gradually in some patients, whereas sudden declines occur in others. The variations in eGFR decline patterns make it difficult for clinicians to identify when eGFR begins declining in each patient.
Can Dehydration Cause Low GFR? Bouts of severe dehydration can sometimes lead to kidney injury and a lower GFR. But it isn't a typical cause of chronic kidney disease (CKD) and low GFR. Chronic dehydration is more likely to lead to other problems, like kidney stones and urinary tract infections.
If the decrease in the estimated glomerular filtration rate (eGFR) is due to acute kidney injury with a sudden decrease in kidney function, this can commonly be reversed. If the kidney disease is due to chronic kidney disease (CKD), the recovery of eGFR is usually not possible.
Following the classical way, we can assert that normal GFR values are largely over 60 mL/min/1.73 m2 in healthy subjects, at least before the age of 70 years. However, we know that GFR physiologically decreases with age, and in adults older than 70 years, values below 60 mL/min/1.73 m2 could be considered normal.
In this population-based study, we examined factors associated with glomerular filtration rates (GFR) in both genders. The findings of our study showed that obesity, diabetes, blood urea nitrogen, atherogenic factor, hypertension, meat consumption, and smoking were associated with lower GFR.
In adults, the normal eGFR number is usually more than 90. eGFR declines with age, even in people without kidney disease. See chart below for average estimated eGFR based on age.
Water ingestion can acutely affect GFR, although not necessarily in the direction one might expect. Using 12 young, healthy individuals as their own controls, Anastasio et al. found increased water intake actually decreases GFR.
A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.
Avoid processed foods and choose fresh fruits and vegetables instead. Follow a low-salt diet. Salt should be limited especially if you have high blood pressure, protein in your urine, or swelling, or difficulty breathing. Eating less than 2000 mg a day of sodium is recommended.
Conclusions: About half of the patients with stage 3 CKD progressed to stage 4 or 5, as assessed by eGFR, over 10 years.
You're more tired, have less energy or are having trouble concentrating. A severe decrease in kidney function can lead to a buildup of toxins and impurities in the blood. This can cause people to feel tired, weak and can make it hard to concentrate.
85-90% of kidney function is gone. GFR falls below 15. Kidneys don't work well enough to keep you alive.
Don't eat ham, bacon, sausage, hot dogs, lunch meats, chicken tenders or nuggets, or regular canned soup. Only eat reduced-sodium soups that don't have potassium chloride as an ingredient (check the food label.) Also, only eat 1 cup, not the whole can.
Non-steroidal anti-inflammatory drugs (NSAIDs)
All the NSAIDs inhibit prostaglandin synthesis, leading to unopposed, intrarenal vasoconstriction. This decreases the glomerular filtration rate.
When your kidneys are failing, a high concentration and accumulation of substances lead to brown, red, or purple urine. Studies suggest the urine color is due to abnormal protein or sugar as well as high numbers of cellular casts and red and white blood cells.
eGFR is considered a mostly reliable test for doctors to know how well your kidneys are working. However, the eGFR may not be accurate if you are younger than 18, pregnant, very overweight or very muscular.
Psychosocial stress was not directly associated with any of the four measures of the eGFR.
GFR Number by Age
The normal range of Kidney Glomerular Filtration Rate is 100 to 130 mL/min/1.73m2 in men and 90 to 120mL/min/1.73m2 in women below 40. GFR decreases progressively after the age of 40 years.