Results: Simparica Trio was generally well tolerated. Emesis occurred at low frequency in all groups including control. Abnormal stool occurred occasionally in the 1× and 3× groups throughout the 3-month study.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval.
Side Effects & Warnings
Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
If your dog does have a history of seizures, it is advised to use different flea and tick medications than those mentioned above. Topical medications such as Advantage, Vectra, Revolution, or Frontline are good choices. Some dogs may have a localized reaction to topical medications.
If chemical products are necessary for additional flea or tick control, NRDC recommends s-methoprene or pyriproxyfen, which are less toxic ingredients—but read the labels carefully because some products use them with other, more harmful pesticides.
The manufacturers says the risk of side effects is very rare, less than one in 10,000 doses sold. Seizures had been mentioned as a possible side effect of Simparica and the other three drugs, but only in very small print, sometimes on the back of the boxes and in the lengthy product inserts inside the boxes.
Simparica Trio should be used with caution in dogs with a history of seizures. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders.
Simparica is safe and effective in the treatment and prevention of flea infestations.
The police dog in question who was given Simparica Trio eventually recovered. It is important to help the animal detox, giving a twice-daily dose of 250-500 mg milk thistle for three to four weeks, plus a few drops of fish oil and a teaspoon of coconut oil daily.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Simparica has yet to be approved for use in breeding, pregnant, or lactating dogs.
Simparica Trio is approved for dogs eight weeks of age and older weighing 2.8 pounds and greater. Simparica Trio is the first and only combination product demonstrated to prevent infections that may cause Lyme disease by killing deer or black-legged ticks.
The answer is yes, flea and tick preventatives need to be applied year-round in order to keep your pets safe. Read on to learn more about how fleas and ticks operate, the dangers they can harbor, and how best to protect your dogs and cats.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio.
The most common signs of toxicity from pyrethrum-based flea products are muscle tremors and excessive salivation. Common signs of toxicity from flea products containing organophosphates are diarrhea, vomiting, difficulty breathing, small pupils, muscle tremor, weakness or falling over, and drooling.
Common breeds that have a higher rate of epilepsy include Beagles, Bernese Mountain Dogs, Border Collies, Boxer Dogs, Cocker Spaniels, Collies, Dachshunds, Golden Retrievers, Irish Setters, Irish Wolfhounds, Keeshonds, Labrador Retrievers, Poodles, St.
Collars such as Seresto will repel fleas and ticks, and even prevent ticks from attaching, but they must be applied tightly enough to have skin contact. Many topical options containing permethrin (e.g. K9 Advantix II, Vectra 3D) will repel and prevent tick attachment.
Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.
Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs).
Monthly Simparica protects dogs from ticks and fleas for 35 days. Have you ever been a few days late giving your dog monthly tick and flea protection?