Furthermore, CoQ10 supplementation confers health benefits in elderly people by preventing chronic oxidative stress associated with cardiovascular and neurodegenerative diseases (Gonzalez-Guardia et al., 2015).
CoQ10 supplements have been shown to improve muscle strength, vitality and physical performance in older adults ( 23 ). To counteract the age-related depletion of CoQ10, it's recommended to take 100–200 mg per day ( 24 ).
For adults 19 years and older: The recommended dose for CoQ10 supplementation is 30 to 200 mg daily. Soft gels tend to be better absorbed than capsules or other preparations. Higher doses may be recommended for specific conditions.
Risks. People with chronic diseases such as heart failure, liver problems, or diabetes should be wary of using this supplement. CoQ10 may lower blood sugar levels and blood pressure.
CoQ10 is safe for most people after the age of 18 and is encouraged for anyone with mitochondrial dysfunction, over the age of 35, or anyone trying or planning to conceive.
CoQ10 eases symptoms of congestive heart failure, which happens when your heart can't pump enough blood to your whole body. It might also help recovery after heart surgery and lower your risk for complications. Some studies suggest it might help lower blood pressure, though the results are mixed.
Fatigue and muscle weakness are signs of a slight CoQ10 deficiency. As mentioned previously, it's unlikely that the general population will experience CoQ10 deficiency; however, in individuals with specific health conditions such as genetic mutations, diabetes, or cancer, there is an increased risk.
Recent research links low blood levels of CoQ10 with low levels of heart-protective “good” cholesterol which in turn may further increase risk for heart disease. Cholesterol-lowering statins may also reduce blood levels of CoQ10.
Safety. No serious side effects of CoQ10 have been reported. Mild side effects such as insomnia or digestive upsets may occur. CoQ10 may interact with the anticoagulant (blood thinner) warfarin and the diabetes drug insulin, and it may not be compatible with some types of cancer treatment.
If you eat sources of saturated fat, like beef, switching to foods with omega-3 fatty acids, like fatty fish, can help lower your heart disease risk. CoQ10 may offer benefits if you already struggle with cardiovascular disease risk or you've had a heart attack.
Many cardiologists place their patients on CoQ10 to help cardiac function as well as to reduce the bad side effects of statin cholesterol drugs. The supplement also may help decrease the pain of rheumatoid arthritis by decreasing the bad inflammatory chemicals that lead to cartilage breakdown.
Answer: Studies with CoQ10 have not shown serious adverse effects at moderate doses even when taken for several years — although it may be best to divide the dose over the course of the day.
Clinical trials have suggested that coenzyme Q10, a non‐prescription nutritional supplement, can effectively lower blood pressure (BP).
CoQ10 positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo.
Other neurological abnormalities that can occur in primary coenzyme Q10 deficiency include seizures, intellectual disability, poor muscle tone (hypotonia), involuntary muscle contractions (dystonia), progressive muscle stiffness (spasticity), abnormal eye movements (nystagmus), vision loss caused by degeneration ( ...
The endogenous production of CoQ10 decreases after the age of 20, and the myocardial concentration of CoQ10 is reduced to about half at the age of 80 (Fig. 3) (Kalén et al., 1989; Gutierrez-Mariscal et al., 2019).
In addition to reducing the risk of cardiovascular problems in patients with liver disease, CoQ10 supplementation may also benefit the disease process within the liver by reducing inflammation and oxidative stress.
In some cases, doses may be gradually increased to 3000 mg per day. For heart failure and fluid build up in the body (congestive heart failure or CHF): 30 mg once daily, or up to 300 mg per day divided into two or three doses for up to 2 years. Also, 2 mg/kg daily for up to one year has been used.
Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease.
Blood Vessel Health and Circulation
CoQ10 neutralizes superoxide and increases nitric oxide levels [20, 21, 22, 23]. In multiple studies of over 135 people, CoQ10 (100 – 300 mg/day) improved blood vessel health and increased circulation.
CoQ10 supplementation reduces oxidative stress and mortality from cardiovascular causes and improves clinical outcome in patients undergoing coronary artery bypass graft surgery, prevents the accumulation of oxLDL in arteries, decreases vascular stiffness and hypertension, improves endothelial dysfunction by reducing ...
The findings showed that taking CoQ10 by patients with CAD significantly decreased total-cholesterol (SMD -1.07; 95% CI, − 1.94, − 0.21, P = 0.01) and increased HDL-cholesterol levels (SMD 1.30; 95% CI, 0.20, 2.41, P = 0.02).
There's no standard guideline for the best time to take CoQ10. However, the general rec is to take CoQ10 in the morning with a meal, due to its potential energizing effects. * But like all supplements, CoQ10 isn't one-size-fits-all—so it's possible that a later-in-the-day dose might work for you.
CoQ10 supplementation is associated with increased energy levels. As with other supplements that boost energy levels, CoQ10 users have reported side effects such as slight stomach upset, headaches, feeling jittery or “wired,” and experiencing mild insomnia.
There are no apparent interactions between vitamin D and CoQ10, showing they're safe to supplement together. Some studies show that CoQ10 and vitamin D are beneficial for supporting heart health and exert protective effects on cardiovascular and renal health.