“Digestion slows down during sleep, so taking your nutrient supplement late at night would not be associated with an efficient absorption.” Neil Levin, a clinical nutritionist at NOW Foods, agrees that morning is best for multivitamins and any B vitamins.
Some people claim that it's better to take vitamins at night because your body gets food and nutrition throughout the day. They argue that taking vitamins at night will be more beneficial for your body as it will absorb the vitamins when you are asleep.
In order to benefit from the energy boost that B vitamins can provide, taking them earlier in the day is preferable, preferably before 2 p.m. A multivitamin or B complex that contains B6 has the potential to interfere with sleep quality and make dreams more vivid."
However, taking a multivitamin too close to bedtime could actually interfere with your ability to fall asleep. Many vitamin formulas contain energizing ingredients that encourage your body to be alert and awake when taken too late in the day.
Combining multiple supplements or taking higher-than-recommended doses can increase the risk that they can cause harm, said Kitchin. "You really can't get toxic doses of nutrients through food, but you can absolutely get toxic doses through supplements," Kitchin said.
Vitamin D and sleep: The surprising connection
Early research suggests it is inversely related to melatonin, your sleep hormone. Increasing vitamin D levels may suppress melatonin levels. So, it makes sense that taking it at night could disrupt your sleep.
Magnesium for sleep
Some studies have found that magnesium supplements can: Make it easier to fall asleep. Improve sleep quality. Reduce symptoms of restless legs syndrome, which can interfere with a good night's sleep.
For most of your supplements—including your daily multivitamin—you should take them with your largest meal of the day, such as lunch or dinner. Ideally, the meal should contain some fat (think fatty fish, avocado, eggs, or nuts) to allow optimal absorption of the fat-soluble vitamins.
When you start taking vitamins, you should expect to experience the following benefits - your energy levels will increase, more food will be converted into energy, your short-term memory will improve, your immune system will become stronger, your muscles will become stronger, and your skin will look healthier.
There's no set time of day that's best to take vitamin D supplements. Some people say taking vitamin D supplements at night is an insomnia risk. There's no research to confirm this, but you might want to take your supplement earlier in the day if you think it's screwing with your sleep.
Growing evidence has demonstrated that vitamin D has a role in sleep regulation [12]. Specifically, vitamin D deficiency (VDD) can increase risk of sleep disorders and is associated with sleep difficulties, shorter sleep duration, and nocturnal awakenings in children and adults [13,14,15].
Magnesium assists in the activation of vitamin D, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys.
Can you take vitamin D and magnesium together? Yes. In fact, it's probably best to take both together. Because so many people have low magnesium levels, vitamin D supplements on their own aren't very helpful for a large portion of the population.
Magnesium assists your body in regulating zinc levels, but high intakes of zinc can be detrimental to magnesium absorption – only abnormally high doses (around 142 mg of zinc per day) will reduce magnesium absorption.
Therefore, conditions that affect the gut and digestion, like celiac disease, chronic pancreatitis, Crohn's disease, and cystic fibrosis, can reduce vitamin D absorption.
Mayo Clinic suggests aiming to leave at least one to two hours between vitamins. “I usually tell people to take them at a separate meal,” says Brissette.
Magnesium supplements should be taken with meals. Taking magnesium supplements on an empty stomach may cause diarrhea.
Vitamin B3 (Niacin)
Tiredness is a common symptom that can arise when thyroid hormones are low. If there's not enough B3 in your diet, you may start to feel tired.