Multiple human papillomavirus (HPV) genotypes often coexist within cervical epithelia and are frequently detected together in smears of different grades of cervical neoplasia.
Of the more than 150 strains of HPV, 40 affect the genital area, but most don't pose a serious risk to health. A person can be infected with more than one HPV strain at a time. Strains are identified by number and fall into either of the following two categories.
A subset of HPV-positive patients was reevaluated to identify persistent infections. We identified HPV types 16, 18, and 39 as the most prevalent. One hundred five of the patients (59%) were infected with more than one type of HPV. The types of HPV associated with multiple HPV infections were 16, 18, and 39.
More than 40 HPV types can infect the genital areas of men and women, including the skin of the penis, vulva (area outside the vagina), and anus, and the linings of the vagina, cervix, and rectum.
The rate of recurrence of genital HPV infection in healthy men — depending on the type — is 20% to 31%, according to researchers. HPV recurrence appears to be influenced by high-risk sexual behavior, they said.
Other factors that may contribute to or help trigger a recurrence of HPV include the use of certain medications that can impair the immune system (e.g., immunosuppression drugs), serious illness, surgery, or HIV infection. The truth is, experts are still not entirely clear about recurrence of HPV.
In most cases (9 out of 10), HPV goes away on its own within two years without health problems. But when HPV does not go away, it can cause health problems like genital warts and cancer.
Does HPV go away? Depending on the type of HPV that you have, the virus can linger in your body for years. In most cases, your body can produce antibodies against the virus and clear the virus within one to two years. Most strains of HPV go away permanently without treatment.
Options include freezing (cryosurgery), laser, surgical removal, loop electrosurgical excision procedure (LEEP) and cold knife conization.
When a high-risk HPV infection persists for many years, it can lead to cell changes that, if untreated, may get worse over time and become cancer. HPV vaccination can prevent cancer: HPV vaccines can prevent infection with disease-causing HPV types, preventing many HPV-related cancers and cases of genital warts.
Age 30-65 years
HPV test every 5 years. HPV/Pap cotest every 5 years. Pap test every 3 years.
A positive HPV test means you do have an HPV type that may be linked to cervical cancer. This does not mean you have cervical cancer now. But it could be a warning. The specific HPV type may be identified to determine the next step.
A positive test result means that you have a type of high-risk HPV that's linked to cervical cancer. It doesn't mean that you have cervical cancer now, but it's a warning sign that cervical cancer could develop in the future.
About 60 of the 100 HPV types cause warts on areas like the hands or feet. The other 40 or so enter the body during sexual contact.
Partners who are sexually intimate only with each other are not likely to pass the same virus back and forth. When HPV infection goes away the immune system will remember that HPV type and keep a new infection of the same HPV type from occurring again.
HPV 16, HPV 58, and HPV 31, all from species group alpha 9, were the most persistent types; however, other high-risk HPV types that are detected rarely in cancer cases were also likely to persist.
Around 90% of HPV infections clear within 2 years. For a small number of women and people with a cervix, their immune system will not be able to get rid of HPV. This is called a persistent infection. A persistent HPV infection causes the cells of the cervix to change.
HPV-related cancers often take years to develop after getting an HPV infection. Cervical cancer usually develops over 10 or more years. There can be a long interval between being infected with HPV, the development of abnormal cells on the cervix and the development of cervical cancer.
Unfortunately, once you have been infected with HPV, there is no treatment that can cure it or eliminate the virus from your system. A hysterectomy removes the cervix, which means that the risk of developing cervical cancer because of persistent HPV infection will essentially be eliminated.
HPV can go away on its own. In most cases—about 90%—your immune system will “clear” an HPV infection within two years (Best, 2013). This means that the virus is no longer present, will not cause symptoms, and you cannot spread it to other people.
Even if you already have one strain of HPV , you could still benefit from the vaccine because it can protect you from other strains that you don't yet have. However, none of the vaccines can treat an existing HPV infection. The vaccines protect you only from specific strains of HPV you haven't been exposed to already.
It's possible. In most cases, your immune system will eventually get rid of an HPV infection within 2 years. But HPV can stay in our bodies – sometimes without us knowing about it, as it is not detected with a test. This is called dormant or clinically insignificant HPV.
If you got a positive HPV test and your Pap test was abnormal, your doctor will probably follow up with a colposcopy. Try to see a physician who specializes in this procedure. During a colposcopy, your doctor will look more closely at the cervix, vagina or vulva with a special microscope called a colposcope.
A colposcopy is a test to take a closer look at your cervix. The cervix is the opening to your womb from your vagina. A colposcopy is often done if cervical screening finds changes to your cells that are caused by certain types of human papillomavirus (HPV). These changed cells can turn into cervical cancer cells.