Applies to escitalopram and citalopram: Generally well tolerated. Non-sedating, low risk of sleep disturbance, comparatively few significant drug interactions. Good choice for initial treatment of depression in most older adults.
Depression among older adults is an often-overlooked health crisis. Studies show that more than half of all people older than 60 diagnosed with depression fail to respond to initial treatment programs. In general, a psychotropic medication such as Lexapro (escitalopram) is one option of many as a first treatment.
This medicine may cause hyponatremia (low sodium in the blood). This is more common in elderly patients, those who are taking diuretic medicines for high blood pressure, or those who have decreased amounts of fluid in the body due to severe diarrhea or vomiting.
In the study, Lenze and colleagues evaluated 177 people aged 60 or older with generalized anxiety disorder who got either Lexapro or a dummy pill for 12 weeks. They found 69 percent of patients got better, compared with 51 percent of those whose symptoms improved simply by taking a placebo.
Usually, SSRIs are considered as the first line treatment of choice. Among the various SSRIs, escitalopram and sertraline are considered to have minimal drug interactions and are considered to be safe in presence of wide range of physical illnesses.
First-line agents for the treatment of depression in older adults include SSRIs, especially citalopram, sertraline, and extended-release venlafaxine. Second-line agents include TCAs, bupropion, and mirtazapine.
SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline. [16] These have the lowest potential for drug-drug interactions based on their cytochrome P-450 interactions.
Buspirone is an anti-anxiety drug that has been shown to be effective for older adults. Benzodiazepines, another anti-anxiety drug, are effective but should be prescribed carefully to older adults because of risk of memory impairment, unsteadiness, and falls.
Applies to escitalopram and citalopram: Generally well tolerated. Non-sedating, low risk of sleep disturbance, comparatively few significant drug interactions. Good choice for initial treatment of depression in most older adults.
Common side effects of Lexapro include nausea, sexual side effects, and insomnia. For some people, these go away as your body gets used to the medication. More serious side effects of Lexapro are rare. These include suicidal thoughts or behaviors, abnormal bleeding, and serotonin syndrome.
Escitalopram is not approved for use by anyone younger than 12 years old. Ask your doctor about taking this medicine if you are pregnant. Taking an SSRI antidepressant during late pregnancy may cause serious medical complications in the baby.
According to the University of Regina research, popular SSRI (Selective Serotonin Reuptake Inhibitors) antidepressant medications, such as Prozac, Paxil, Lexapro, Zoloft, etc., are associated with a twofold increase in the odds of developing some form of cognitive impairment, such as dementia, including Alzheimer's.
Lexapro is prescribed long-term, allowing it to create neuroadaptation in the CNS, brain, and body. Long-term effects of Lexapro may develop making continuing treatment untenable. Lexapro is not a cure.
How long can you take Lexapro? If this is your first episode of depression, your doctor may prescribe Lexapro for a set period, for example, 6 months to a year. Some people with persistent depression may need to take it for many years. There are no known problems when Lexapro is taken long-term.
Lexapro is not approved for use in pediatric patients less than 12 years of age.
Anxiety in the elderly, often accompanied by depression, can lead to worsening physical, cognitive and functional impairments in this vulnerable population. Antidepressants are considered first line treatment.
Anxiety becomes more common with older age and is most common among middle-aged adults. This may be due to a number of factors, including changes in the brain and nervous system as we age, and being more likely to experience stressful life events that can trigger anxiety.
Some common risk factors for anxiety disorders in seniors include: Stressful life events (e.g., death of a loved one) Limited physical mobility. Loss of independence.
Medications you might get include: Selective serotonin reuptake inhibitors (SSRIs) like citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft)
Citalopram, moclobemide, and probably fluoxetine are more effective than placebo in older depressed patients. The serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline as well as milnacipran and venlafaxine are probably (but not unequivocally) as effective as older antidepressants in this population.
Selective serotonin reuptake inhibitors (SSRIs).
Health care providers often start by prescribing an SSRI . These antidepressants generally cause fewer bothersome side effects and are less likely to cause problems at higher therapeutic doses than other types of antidepressants.