Unlike diseases or conditions like diabetes or kidney stones, there is no one test for sepsis testing. However, your doctor makes the diagnosis by evaluating your symptoms, your history, and other tests. This can then lead your doctor to suspect you have sepsis.
Blood tests may reveal the following signs suggestive of sepsis: Elevated or low white blood cells – Higher than usual levels of leukocytes, known as white blood cells (WBCs), are a sign of a current infection, while too few WBCs indicate that a person is at higher risk of developing one.
a wound culture – where a small sample of tissue, skin or fluid is taken from the affected area for testing. respiratory secretion testing – taking a sample of saliva, phlegm or mucus. blood pressure tests. imaging studies – like an X-ray, ultrasound scan or computerised tomography (CT) scan.
Laboratory Tests
FBC (Full blood count) – to evaluate red and white blood cells and platelets. Lactate – increased levels can indicate organ dysfunction. Blood gases – to evaluate oxygen in the blood and acid-base balance. C-reactive protein (CRP) – to detect inflammation in the body.
Sepsis can develop quickly from initial infection and progress to septic shock in as little as 12 to 24 hours.1 You may have an infection that's not improving or you could even be sick without realizing it.
Immediate action required: Call 999 or go to A&E if:
a rash that does not fade when you roll a glass over it, the same as meningitis. difficulty breathing (you may notice grunting noises or their stomach sucking under their ribcage), breathlessness or breathing very fast.
WBC, C-reactive protein (CRP) and interleukin-1 (IL-1) are the conventional markers used for diagnosis of sepsis.
Bacterial infections cause most cases of sepsis. Sepsis can also be a result of other infections, including viral infections, such as COVID-19 or influenza, or fungal infections.
Sepsis can be divided into three stages: sepsis, severe sepsis and septic shock.
Complete blood count (CBC): A CBC is a common blood test. It measures how many white blood cells are circulating in your blood, among other things. White blood cells (also called leukocytes) fight bacteria, viruses, and other organisms your body identifies as a danger.
The condition can arise suddenly and progress quickly, and it's often hard to recognize. Sepsis was once commonly known as “blood poisoning.” It was almost always deadly. Today, even with early treatment, sepsis kills about 1 in 5 affected people.
If you have sepsis, you already have a serious infection. Early symptoms include fever and feeling unwell, faint, weak, or confused. You may notice your heart rate and breathing are faster than usual. If it's not treated, sepsis can harm your organs, make it hard to breathe, and mess up your thinking.
Most symptoms of post-sepsis syndrome should get better on their own. But it can take time. There are things you can do to help with some long-term effects.
Antibiotics alone won't treat sepsis; you also need fluids. The body needs extra fluids to help keep the blood pressure from dropping dangerously low, causing shock. Giving IV fluids allows the health care staff to track the amount of fluid and to control the type of fluid.
Stage one: Systemic Inflammatory Response Syndrome (SIRS)
Sepsis can be hard to identify, but is typically denoted by a very high or low body temperature, high heart rate, high respiratory rate, high or low white blood cell count and a known or suspected infection.
Anyone can develop sepsis, but some people are at higher risk for sepsis: Adults 65 or older. People with weakened immune systems. People with chronic medical conditions, such as diabetes, lung disease, cancer, and kidney disease.
Organ failure, including kidney failure, is a hallmark of sepsis. As the body is overwhelmed, its organs begin to shut down, causing even more problems. The kidneys are often among the first to be affected.
As sepsis worsens or septic shock develops, an early sign, particularly in older people or the very young, may be confusion or decreased alertness. Blood pressure decreases, yet the skin is paradoxically warm. Later, extremities become cool and pale, with peripheral cyanosis and mottling.
I – Infection – may have signs and symptoms of an infection.
If the infection has spread or you have a generalized infection, you may develop other signs and symptoms, such as fever, fatigue, pain, etc. Sometimes however, you may have an infection and not know it, and not have any symptoms.
It's clear that sepsis doesn't occur without an infection in your body, but it is possible that someone develops sepsis without realizing they had an infection in the first place. And sometimes, doctors never discover what the initial infection was.
Sepsis is known as the 'silent killer' because its symptoms often mimic that of other illnesses such as the flu or gastro. But, if it is identified and treated early, patients can recover.
However, there might be other symptoms related to sepsis based on where the infection is. Abdominal pain is one such symptom.