Vitamin D3 provides support for a variety of body systems. This support is important for those who suffer from
Vitamin B6 and Vitamin C, in particular, have been shown to reduce symptoms of seasickness and histamine intolerance.
Vitamin D is required to maintain the stability of mast cells, and Vitamin D deficiency results in mast cell activation.
There is currently no cure for histamine intolerance. The key to success is for the patient to learn to adjust to a low-histamine diet and manage the condition(s) until it either goes away, or for life. The patient needs to avoid stress.
Some experts believe that a deficiency in vitamin B6 and C is linked with histamine intolerance; these vitamins have been shown to relieve histamine intolerance symptoms.
Magnesium is a mineral that relieves the constriction of the airways in the lungs. It's been found that magnesium deficiency can cause an increase in histamine levels in the blood after being exposed to allergens.
There is evidence that vitamin C acts as a natural antihistamine and antioxidant and that it can help decrease inflammation and swelling at the site of an allergic reaction.
Boswellia, also known as frankincense, is a potent anti-inflammatory herbal medicine that can help to stabalise mast cells and reduce histamine load in the body.
Vitamin C
Vitamin C boosts the immune system. It also acts as a natural antihistamine. According to a 2018 study on vitamin C in the treatment of allergies, oxidative stress plays a key role in allergic diseases. As vitamin C is a powerful antioxidant and anti-inflammatory, it may act as a treatment for allergies.
It is widely thought that vitamin D plays an important role in the modulation of the inflammation system by regulating the production of inflammatory cytokines and immune cells, which are crucial for the pathogenesis of many immune-related diseases.
It's believed that Vitamin D helps regulate immune system cells and the release of chemicals that can produce allergy symptoms. One study, involving people with a Vitamin D deficiency, found that when they took Vitamin D supplements and antihistamines, their allergy symptoms improved after eight weeks.
Researchers found after just one week, the severity of patients' symptoms decreased by 33 percent for both groups. But at the end of three months, the group taking 4000 IUs of vitamin D3 had a further 40 percent decrease in severity of their hives.
Vitamin C is a natural antihistamine, which means it can lower histamine levels and mitigate allergic reactions and symptoms. Consume plenty of Vitamin C rich foods, like tropical fruits, citrus fruits, broccoli and cauliflower, and berries.
Claritin and Zyrtec are effective and safe for most people with minor allergies.
Allergies are your body's reaction to a foreign protein. Usually, these proteins (allergens) are harmless. However, if you have an allergy to a particular protein, your immune system overreacts to its presence in your body. A cascade of reactions leads to a release of histamine, which causes allergy symptoms.
For these people, histamine builds up in the body and is not broken down correctly. This can trigger an immune system response resulting in symptoms such as diarrhea, shortness of breath, headaches, or skin irritation.
Allergies and Vitamin D
Furthermore, research shows that vitamin D can activate certain regulatory immune system cells that prevent the release of chemicals that cause and worsen allergic diseases. 1 So a deficiency in vitamin D may inhibit this regulatory mechanism, which may worsen or trigger allergic disease.
The zinc chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) inhibits the release of histamine, the production of cytokines, and the secretion of lipid mediators in mast cells, and zinc supplementation rescues these inhibitory effects.
Besides, magnesium helps in lowering histamine levels and reduction of various inflammation types in the lungs and airways in general (13).
Histamine is stored in the granules of mast cells, basophils, platelets. This histamine is released from these cells by the stimuli inducing acute inflammation, anaphylatoxins, and histamine releasing factors.
How is histamine broken down? In the CNS (Central Nervous System) histamine is broken down by HMT (Histamine Methyltransferase) enzyme. This means that impaired methylation can contribute to high histamine levels. In some cases, methylated B vitamins and supplements such as DMG and TMG can help reduce histamine levels.
Studies suggest that vitamin B12 can trigger histamine release in the body. Certain bacteria or yeasts can convert histidine into histamine in the body, triggering an allergic reaction.