So current medical guidelines recommend statins for people in that no-heart-disease category, a strategy called primary prevention — but only for those up to age 75. Yet almost half of adults aged 75 and older take statins, the Centers for Disease Control and Prevention has reported.
A slew of recent studies have shown that statins may have significant benefits in older age groups. “Your physiology doesn't suddenly change when you turn 75 years of age,” says Steven Nissen, M.D., chair of cardiovascular medicine at the Cleveland Clinic.
Do not start a statin in patients ages ≥ 75 years who do not have known vascular disease or type 2 diabetes; start or continue a statin in all patients ages 75 to 84 with type 2 diabetes to prevent cardiovascular events and mortality; and start or continue a statin in patients ages > 75 years who have known vascular ...
Statin therapy may be associated with a variety of musculoskeletal disorders, including myopathy, myalgias, muscle weakness, back conditions, injuries, and arthropathies. These disorders may be particularly problematic in older people and may contribute to physical deconditioning and frailty.
The task force recommends that people ages 40 to 75 years at high risk for CVD should initiate statin use to prevent a heart attack or stroke. People in the same age range who are at increased risk should talk to their doctor about whether a statin is appropriate.
Statins should be taken with caution if you're at an increased risk of developing a rare side effect called myopathy, which is where the tissues of your muscles become damaged and painful. Severe myopathy (rhabdomyolysis) can lead to kidney damage. Things that can increase this risk include: being over 70 years old.
Statins are medications designed to lower cholesterol to decrease your risk of cardiovascular issues, such as heart attacks. Recent research shows that people 75 and older who go off statins have an increased risk of hospitalization because of cardiovascular problems.
While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people. Rarely, they may cause liver damage. If you think you're experiencing side effects from taking statins, don't just stop taking the pills.
If you've made lifestyle changes through diet and exercise that have lowered your cholesterol levels, you may not need to continue taking a statin. These changes can help reduce your risk of heart attack, stroke, or blocked arteries while allowing you to take one less medication.
Atorvastatin or fluvastatin are usually recommended because there is no need to adjust the dose according to the glomerular filtration rate [28]. In patients without diagnosed atherosclerotic cardiovascular disease, it is indicated a moderate dose of statin, such as atorvastatin 20 mg daily [28].
The American College of Cardiology and American Heart Association developed some prescription guidelines. Typically, if a person's LDL cholesterol (bad cholesterol) is 190 or higher, they're often advised to start a statin.
However, statins can cause side effects in older adults including gait disturbances, which can lead to falls; increased blood glucose levels and incidence of diabetes mellitus; development of cataracts; liver toxicity; and muscle complications such as rhabdomyolysis, which is a potentially life-threatening condition.
Currently, more than 60 percent of older people in the United States who, like me, have high cholesterol take a statin to help prevent a heart attack or stroke.
Fear of side effects and perceived side effects are the most common reasons for declining or discontinuing statin therapy. Willingness to take a statin is high, among both patients who have declined statin therapy and those who have never been offered one.
We have data now from over 20 statin trials of over 135,000 patients that show statins compared with placebo or no medication result in a 23 percent reduction in heart attacks, 17 percent reduction in fatal or non-fatal stroke and 19 percent reduction in death from cardiovascular causes. So, they definitely work.
Rhabdomyolysis is the most serious adverse effect from statin use, though it occurs quite rarely (less than 0.1%). The most common risk factors for statin-related myopathy include hypothyroidism, polypharmacy and alcohol abuse.
If your risk is very low, you probably won't need a statin, unless your LDL is above 190 mg/dL (4.92 mmol/L). If your risk is very high — for example, you've had a heart attack in the past — a statin may be helpful even if you don't have high cholesterol.
So current medical guidelines recommend statins for people in that no-heart-disease category, a strategy called primary prevention — but only for those up to age 75. Yet almost half of adults aged 75 and older take statins, the Centers for Disease Control and Prevention has reported.
Joseph A. Hill, M.D., Ph. D. The controversy in the United Kingdom started in 2013 when the British Medical Journal (BMJ) claimed statins were being overprescribed to people with low risk of heart disease, and that the drugs' side effects were worse than previously thought.
Elevated cholesterol levels are not uncommon in the elderly (61% of women aged between 65 and 74 have total cholesterol levels over 6.2 mmol/L [240 mg/dL]).
Most people can lower high cholesterol with lifestyle changes, like prioritizing heart-healthy foods, quitting tobacco products, exercising regularly, and sleeping enough. Making changes to lower your cholesterol might mean you don't need to take cholesterol medication anymore (or deal with the side effects).
High cholesterol levels are considered: too high: between 5 and 6.4mmol/l. very high: between 6.5 and 7.8mmol/l. extremely high: above 7.8mmol/l.
A Statin Alternative Lowers Heart Attack Risk by 23 Percent, Drug Trial Shows. People who can't or won't take statin medications to reduce LDL cholesterol may want to talk to their doctor about bempedoic acid (Nexletol).