High heart rate or weak pulse. Fever, shivering, or feeling very cold. Confusion or disorientation. Shortness of breath.
Severe breathlessness or sleepiness. It feels like you're going to die or pass out. Skin mottled or discoloured. An extremely high or a very low temperature; repeated vomiting; seizures; and a rash which doesn't fade when you press a glass against it are also possible 'red flags'.
As sepsis worsens or septic shock develops, an early sign, particularly in older people or the very young, may be confusion or decreased alertness. Blood pressure decreases, yet the skin is paradoxically warm. Later, extremities become cool and pale, with peripheral cyanosis and mottling.
Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Infections that lead to sepsis most often start in the lung, urinary tract, skin, or gastrointestinal tract. Without timely treatment, sepsis can rapidly lead to tissue damage, organ failure, and death.
Sepsis can develop quickly from initial infection and progress to septic shock in as little as 12 to 24 hours.1 You may have an infection that's not improving or you could even be sick without realizing it.
a high temperature (fever) or low body temperature. a change in mental state – like confusion or disorientation. slurred speech. cold, clammy and pale or mottled skin.
Sepsis is known as the 'silent killer' because its symptoms often mimic that of other illnesses such as the flu or gastro. But, if it is identified and treated early, patients can recover.
However, there might be other symptoms related to sepsis based on where the infection is. Abdominal pain is one such symptom.
It's clear that sepsis doesn't occur without an infection in your body, but it is possible that someone develops sepsis without realizing they had an infection in the first place. And sometimes, doctors never discover what the initial infection was.
If you have sepsis, you already have a serious infection. Early symptoms include fever and feeling unwell, faint, weak, or confused. You may notice your heart rate and breathing are faster than usual. If it's not treated, sepsis can harm your organs, make it hard to breathe, and mess up your thinking.
People with sepsis often develop a hemorrhagic rash—a cluster of tiny blood spots that look like pinpricks in the skin. If untreated, these gradually get bigger and begin to look like fresh bruises. These bruises then join together to form larger areas of purple skin damage and discoloration.
The condition can arise suddenly and progress quickly, and it's often hard to recognize. Sepsis was once commonly known as “blood poisoning.” It was almost always deadly. Today, even with early treatment, sepsis kills about 1 in 5 affected people.
Sepsis can overwhelm the body. This can cause vital organs to shut down. This usually starts with the kidneys. Blood pressure can drop dangerously low.
What causes sepsis? Most sepsis is caused by bacterial infections, but it can also be caused by viral infections, such as COVID-19 or influenza; fungal infections; or noninfectious insults, such as traumatic injury.
NICE - the National Institute for Health and Care Excellence - urges hospital staff to treat people with life-threatening sepsis within one hour, in its quality standard. In clinical practice, this is often referred to as the 'golden hour' after diagnosis.
Many conditions mimic sepsis by meeting criteria for SIRS.
These conditions include: pulmonary embolism (PE), adrenal insufficiency, diabetic ketoacidosis (DKA), pancreatitis, anaphylaxis, bowel obstruction, hypovolemia, colitis, vasculitis, toxin ingestion/overdose/withdrawal, and medication effect.
The organs more frequently affected are kidneys, liver, lungs, heart, central nervous system, and hematologic system. This multiple organ failure is the hallmark of sepsis and determines patients' course from infection to recovery or death.
These long-term effects are sometimes called post-sepsis syndrome, and can include: feeling very tired and weak, and difficulty sleeping. lack of appetite.
Sepsis may cause atypical blood clotting. The resulting small clots or burst blood vessels may damage or destroy tissues. Most people recover from mild sepsis, but the mortality rate for septic shock is about 30% to 40%.
While it may seem like a minor cut or a urinary tract infection that will go away, untreated both could lead to sepsis a dangerous infection that is potentially life-threatening. Any type of infection, anywhere in the body, can cause sepsis.
Septic shock: Septic shock is the last stage of sepsis and is defined by extremely low blood pressure, despite lots of IV (intravenous) fluids.
A single diagnostic test for sepsis does not yet exist, and so doctors and healthcare professionals use a combination of tests and immediate and worrisome clinical signs, which include the following: The presence of an infection. Very low blood pressure and high heart rate. Increased breathing rate.
Complete blood count (CBC): A CBC is a common blood test. It measures how many white blood cells are circulating in your blood, among other things. White blood cells (also called leukocytes) fight bacteria, viruses, and other organisms your body identifies as a danger.
If the infection has spread or you have a generalized infection, you may develop other signs and symptoms, such as fever, fatigue, pain, etc. Sometimes however, you may have an infection and not know it, and not have any symptoms.