One person with lupus may experience malar rashes, kidney involvement, and memory loss, while another can have seizures, pleurisy, or hair loss. Though any of these symptoms could be a manifestation of lupus, they also could signal another, problem.
Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis.
A tell-tale sign of lupus is a butterfly-shaped rash across the cheeks and bridge of the nose. Other common skin problems include sensitivity to the sun with flaky, red spots or a scaly, purple rash on various parts of the body, including the face, neck, and arms. Some people also develop mouth sores.
Kidneys About one half of people with lupus experience kidney involvement, and the kidney has become the most extensively studied organ affected by lupus.
Your doctor will look for rashes and other signs that something is wrong. Blood and urine tests. The antinuclear antibody (ANA) test can show if your immune system is more likely to make the autoantibodies of lupus. Most people with lupus test positive for ANA.
The coexistence of Sjogren's syndrome with lupus was first described in 1959. Since that report, numerous studies have compared and contrasted the two diseases.
Viruses that have been linked to lupus include: Cytomegalovirus. Epstein-Barr virus, which causes mononucleosis. Varicella-zoster virus, which causes chickenpox and shingles.
The effects lupus may have in and around the eyes include: changes in the skin around the eyelids, dry eyes, inflammation of the white outer layer of the eyeball, blood vessel changes in the retina, and damage to nerves controlling eye movement and affecting vision.
Hair loss is common in people living with lupus. The autoimmune disease causes body-wide inflammation that attacks the joints and skin, including the scalp. This can result in hair loss (alopecia ). Lupus-related hair loss can occur slowly, causing hair to become noticeably thinner gradually.
Neonatal lupus and drug-induced lupus are the least common types of lupus.
Many people who have active lupus feel ill in general. They have fever, weight loss, and fatigue. When their immune system attacks a certain organ or part of the body, they can also have more specific problems.
For example, untreated lupus can lead to blood disorders such as anemia or thrombosis. Other potential serious complications include: Chronic digestive distress that could include difficulty swallowing, dry mouth, indigestion, intestinal inflammation, liver enlargement, or pain when vomiting or feeling nauseous.
A 2018 review considered several case reports of people with both conditions. The researchers noted that this is a rare occurrence. Sometimes, lupus can cause the body to attack the nervous system. This can create symptoms similar to those of MS, and it may lead to a misdiagnosis.
They're both autoimmune diseases.
In MS, your own immune system attacks your nervous system by mistake and damages your nerves. In lupus, your immune system attacks healthy tissues like your skin, joints, kidneys, heart, or lungs. But it can also damage your nerves and brain.
In general, a brain MRI will show more lesions with MS ("black holes and bright spots") but sometimes the brain lesions found with lupus or MS can be indistinguishable.
The diagnosis is based mainly on your doctor talking to you and examining you. They will ask you questions about your symptoms and refer you for blood tests. These usually include an anti-nuclear antibody (ANA) test, which checks whether you have antibodies to your own cells.
Anti-Nuclear Antibody (ANA) Test. Anti-nuclear antibodies (ANA) are autoantibodies to the nuclei of your cells. 98% of all people with systemic lupus have a positive ANA test, making it the most sensitive diagnostic test for confirming diagnosis of the disease.
Rashes that develop on the face and upper arms after exposure to sunlight, unexplained fevers, and painful, swollen, or stiff joints are all common lupus symptoms — and are symptoms you should tell your doctor about, says Neil Kramer, MD, a rheumatologist at the Institute for Rheumatic and Autoimmune Diseases at ...