Serious side effects are uncommon and happen in less than 1 in 100 people. Call a doctor or contact 111 immediately if: the whites of your eyes turn yellow, or your skin turns yellow although this may be less obvious on brown or black skin, or if you have pale poo and dark pee – these can be signs of liver problems.
In some people, fluconazole may cause dizziness and affect their ability to drive a car or operate machinery. Avoid alcohol. Specimens or swabs should be taken before fluconazole is initiated.
Fluconazole can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.
This drug may also make existing kidney disease worse. People with liver problems: Fluconazole can cause liver problems. If you already have liver problems, talk with your healthcare professional before taking this drug.
This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.
The pattern of fluconazole induced liver injury is typically hepatocellular, arising within the first few weeks of therapy and may be accompanied by signs of hypersensitivity such as fever, rash and eosinophilia.
If a single dose does not completely relieve symptoms, or the infection is severe, fluconazole can be prescribed as three consecutive doses given three days apart. With this regimen it's expected that symptoms should improve within one to two weeks.
The usual doses for adults are: oral (mouth) thrush – 50mg a day, taken for 7 to 14 days. vaginal thrush or balanitis – 150mg, taken as a single dose. vaginal thrush that keeps coming back – 150mg, taken once every 72 hours for the first 3 doses, then 150mg once a week for 6 months.
If you have vaginal thrush, balanitis or oral thrush, your symptoms should be better within 7 days of taking fluconazole. If you have a serious fungal infection, ask your doctor how long it will take for fluconazole to start to work. It may be 1 to 2 weeks before it reaches its full effect.
Fluconazole can be taken at any time of day, and can be taken either before or after a meal. Swallow the capsule with a drink of water. Infections such as vaginal thrush can be treated with a single 150 mg dose; other infections require a course of treatment possibly lasting a number of weeks.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluconazole in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving fluconazole.
Fluconazole is not suitable for some people. To make sure it's safe for you, tell a pharmacist or your doctor before taking it if you have: ever had an allergic reaction to fluconazole or any other medicine. a heart condition, including heart rhythm problems (arrhythmia)
The severity of liver injury from fluconazole ranges from mild and transient enzyme elevations to clinically apparent hepatitis to acute liver failure and death. Most patients recover with stopping fluconazole, but resolution may be slow requiring 3 to 4 months. Rechallenge may lead to recurrence and should be avoided.
If you have a vaginal yeast infection, you may only need one dose of fluconazole and may see your symptoms start to improve within 24 hours. If your symptoms don't improve within 3 days, contact your healthcare provider for next steps. You may need another dose.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
If you don't really have a yeast infection, antifungals won't help you get better. They can actually prolong the real problem, because while you'll think you're treating the issue, the real cause will continue to develop.
The authors conclude that although single-dose fluconazole is highly effective in complicated Candida vaginal infections, the clinical cure rate is better when a second sequential dose is used. This may not be true in infections caused by non-albicans species.
The rates of clinical effectiveness were 92% or 88% in the 6-day oral fluconzaole group, 80% or 76% in the single oral fluconazole group, and 72% or 58% in the intravaginal clotrimazole group at the short-term or long-term assessment, respectively. Treatment-related side effects were not found in any group.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
Fluconazole is usually prescribed as a single 150 mg dose and an improvement in symptoms is usually seen within one to three days. Typically, in 90% of women, a single dose will clear the infection with vaginal yeast cultures becoming negative within 72 to 96 hours.
In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites.
Dangerous for the environment. Additional Hazard Information: Long Term: Repeat-dose studies in animals have shown a potential to cause adverse effects on : liver. Rare cases of serious liver damage and allergic reactions have been reported . defects have occurred in infants of women taking this drug.