Gamma-glutamyl transpeptidase test: This test measures the level of gamma-glutamyl transpeptidase (an enzyme that is produced in the liver, pancreas, and biliary tract). This test is often performed to assess liver function, to provide information about liver diseases, and to detect alcohol ingestion.
Alcohol-related liver disease (ARLD) is often first suspected when tests for other medical conditions show a damaged liver. This is because the condition causes few obvious symptoms in the early stages. If a doctor suspects ARLD, they'll usually arrange a blood test to check how well your liver is working.
Blood tests
A low level of serum albumin suggests your liver isn't functioning properly. A blood test may also look for signs of abnormal blood clotting, which can indicate significant liver damage. Lab Tests Online has more information on liver function tests.
Liver disease is the most likely diagnosis if the AST level is more than twice that of ALT (9), a ratio some studies have found in more than 80 percent of alcoholic liver disease patients. An elevated level of the liver enzyme GGT is another gauge of heavy alcohol use and liver injury.
The predominance of AST over ALT in alcohol-related liver disease was first reported by Harinasuta et al. in 1967. Many authors have since described AST/ALT ratios greater than 1.5 or greater than 2.0 as being highly suggestive of alcoholic hepatitis.
An AST/ALT ratio higher than one (where the AST is higher than ALT) means you may have cirrhosis. An AST/ALT ratio higher than 2:1 (where the AST is more than twice as high as the ALT) is a sign of alcoholic liver disease.
An elevated serum AST in relation to serum ALT (alanine aminotransferase) has been proposed as an indicator that alcohol has induced organ damage. Thus, when AST/ALT ratio is >1.5, this is considered as highly suggestive that alcohol is the cause of the patient's liver injury (Correia et al., 1981; Salaspuro, 1987).
Medical professionals are able to detect, however, if you are making up this information as there may be certain indicators that appear. For example, elevated enzyme levels or high blood pressure might give them a clue into excessive drinking habits.
If you stop drinking alcohol for some time (months or years), your liver should return to normal.
Some alcohol-related liver damage can be reversed if you stop drinking alcohol early enough in the disease process. Healing can begin as early as a few days to weeks after you stop drinking, but if the damage is severe, healing can take several months.
It is estimated that alcohol-related fatty liver disease develops in 90% of people who drink more than 40g of alcohol (or four units) per day. That's roughly the equivalent of two medium (175ml) glasses of 12% ABV wine, or less than two pints of regular strength (4% ABV) beer.
Blood tests can help to identify excessive alcohol use and possible liver damage. These tests have a low sensitivity and therefore should be used only to confirm suspected alcohol problems, not as a sole screening test. Blood tests can also be used to monitor changes in patients' alcohol consumption.
The biochemical markers for chronic alcohol consumption that have been most commonly studied are serum GGT, AST, ALT, mean corpuscular volume (MCV) and carbohydrate-deficient transferrin (CDT)[82-84].
How long do you have to drink before liver damage? People with serious liver damage have usually been drinking for 20 or more years. But complications can develop after 5 to 10 years of heavy drinking. Again, this can be highly variable between individuals and is likely genetic.
Blood tests can help identify excessive alcohol use and possible liver damage. They may also be used to monitor changes in someone's alcohol consumption during recovery.
Blood alcohol levels, breathalyzer test results, urine drug screens, and, less commonly, hair and saliva analysis can be used to assess patients for possible alcohol and other drug use.
Blood tests specifically prohibiting alcohol consumption prior to the administration include the triglyceride test and the gamma glutamyl transferase (GGT) test. It will lead to an elevated level of LFT's (Liver Function Tests).
There are usually few symptoms in the early stages of cirrhosis. However, as your liver loses its ability to function properly, you're likely to experience a loss of appetite, nausea and itchy skin.
Acute liver failure can develop quickly in an otherwise healthy person, and it is life-threatening. If you or someone you know suddenly develops a yellowing of the eyes or skin; tenderness in the upper abdomen; or any unusual changes in mental state, personality or behavior, seek medical attention right away.
ANOVA analyses of the trends according to the frequency of binge drinking showed a significant GGT increase in both men (p < 0.0005) and women (p < 0.0005), and a significant increase of ALT in men (p < 0.0005).
This study demonstrates that even very modest levels of alcohol intake can significantly affect liver enzymes and the most sensitive measure of alcohol intake is the enzyme GGT which is potentiated by alcohol intake as low as 7–14 g/day.
The most common causes of elevated ALT levels in subjects undergoing health screening exams are alcohol intake, viral hepatitis, and NAFLD [18].