Pernicious anemia causes the tongue's surface to look smooth and appear red instead of the pinkish color of a normal tongue. The tongue might also appear thick or beefy in texture. Some tongues might even be swollen or seem to have cracks.
One large sign of anemia is called anemia tongue. It is typically characterized by an inflamed or swollen tongue in multiple shades of red. Other signs include impaired chewing, swallowing or speaking abilities, tongue pain or tenderness.
People with pernicious anemia may have gastric polyps. They are also more likely to develop gastric cancer and gastric carcinoid tumors. People with pernicious anemia are more likely to have fractures of the back, upper leg, and upper forearm.
Iron deficiency can also cause the appearance of sore, red, flaky cracks at one or both of the sides of your mouth. This feels more extreme than when your lips are chapped due to cold weather. Mouth ulcers are sore white patches on the inside your mouth.
One large effect of anemia may be what is called anemia tongue. It is mainly characterized by an inflamed or swollen tongue in multiple shades of red.
The exact cause of pernicious anaemia is unknown, but it's more common in women around 60 years of age, people with a family history of the condition and those with another autoimmune condition, such as Addison's disease or vitiligo.
These symptoms include nausea (feeling sick to your stomach) and vomiting, heartburn, abdominal bloating and gas, constipation or diarrhea, loss of appetite, and weight loss. An enlarged liver is another symptom. A smooth, thick, red tongue also is a sign of vitamin B12 deficiency and pernicious anemia.
Currently, early recognition and treatment of pernicious anemia provide a normal, and usually uncomplicated, lifespan. Delayed treatment permits progression of the anemia and neurologic complications. If patients are not treated early in the disease, neurologic complications can become permanent.
People who have pernicious anemia do not produce intrinsic factor. Pernicious anemia is more common in people with northern European or African ancestry. You may develop vitamin B12–deficiency anemia if your body is not able to absorb enough vitamin B12 from the foods you eat.
People with vitamin B12 deficiency can have neurological symptoms and/or damage without anemia (lack of red blood cells). General physical symptoms of vitamin B12 deficiency can include: Feeling very tired or weak. Experiencing nausea, vomiting or diarrhea.
Pernicious anemia causes the tongue's surface to look smooth and appear red instead of the pinkish color of a normal tongue. The tongue might also appear thick or beefy in texture. Some tongues might even be swollen or seem to have cracks.
Approximately 50% of patients with pernicious anemia develop atrophic glossitis, presenting with a smooth tongue that may be painful and beefy red, with loss of papillae that is usually most marked along the edges of the tongue.
Deficiencies in B6 or B12 may lead to a swollen, sore or yellow tongue, along with teeth indentations and fissures on the surface of the tongue. Iron: An iron deficiency can lead to a swollen tongue and painful sores in the mouth.
Blood tests and procedures can help diagnose pernicious anemia and find out what's causing it.
With proper treatment, people who have pernicious anemia can recover, feel well, and live normal lives. If you have complications of pernicious anemia, such as nerve damage, early treatment may help reverse the damage.
Stage 1 is decreased levels of vitamin B12 in the blood. Stage 2 is low concentration of vitamin B12 in the cell and metabolic abnormalities. Stage 3 is increased levels of homocysteine and MMA and decreased DNA synthesis resulting in neuropsychiatric symptoms. Stage 4 is macrocytic anemia.
Pernicious anemia usually is easy to treat with vitamin B12 shots or pills. If you have severe pernicious anemia, your doctor may recommend shots first. Shots usually are given in a muscle every day or every week until the level of vitamin B12 in your blood increases.
If you suspect you might have an anemic disorder, check yourself for the following symptoms and call your doctor for further advice. A sudden lack of energy and chronic fatigue are warning signs that you might be lacking enough iron.
Anemia is a problem of not having enough healthy red blood cells or hemoglobin to carry oxygen to the body's tissues. Hemoglobin is a protein found in red cells that carries oxygen from the lungs to all other organs in the body. Having anemia can cause tiredness, weakness and shortness of breath.
Fatigue. Tiring easily, and waking up tired even after a good night's sleep, are common and potentially serious symptoms of anemia. This is due to reduced and compromised red blood cells that naturally cannot carry the required levels of oxygen to the organs – which, in turn, cannot function efficiently.
Koilonychia is an abnormal shape of the fingernail. The nail has raised ridges and is thin and curved inward. This disorder is associated with iron deficiency anemia.