Quitting an antidepressant suddenly may cause symptoms within a day or two, such as: Anxiety. Insomnia or vivid dreams. Headaches.
If the symptoms develop later or gradually, they may constitute a relapse of the depression. Ultimately, these withdrawal symptoms will improve with time, but they can be unpleasant for days and possibly even weeks. In time, the brain readjusts and people should experience a return to their normal state.
When stopping antidepressants, some symptoms may persist for up to 6 weeks and occasionally may continue for up to a year . Always speak with a doctor about any new symptoms that occur when tapering off an antidepressant.
We know that antipsychotics shrink the brain in a dose-dependent manner (4) and benzodiazepines, antidepressants and ADHD drugs also seem to cause permanent brain damage (5).
Do I have to take antidepressants forever is a question that some ask as they struggle with depression. This is one of the more common myths associated with the condition. You do not need to take antidepressants forever nor do you need to get a prescription from a counselor or therapist.
It is well known that harms caused by SSRIs can be long-lasting [18] and there are indications that they can even be permanent, e.g. for sexual disturbances [39, 40]. Withdrawal symptoms are also drug harms, and they can also persist for a long time [18].
Those who had used antidepressants for >3 years reported more severe side effects, including “weight gain”, “addiction”, “feeling not like myself ”, “withdrawal symptoms”, and “suicidality”, than those who had been on antidepressants for ≤2 years.
Do Antidepressants Permanently Alter Brain Chemistry? Antidepressants are designed to alter brain chemistry to alleviate symptoms—thus, they do so while you are taking them. They may promote potentially beneficial structural brain changes, as well.
Withdrawal symptoms typically persist for up to three weeks. The symptoms gradually fade during this time. Most people who quit taking their antidepressants stop having symptoms after three weeks. There are many factors that affect how long withdrawal symptoms last.
Neurotransmitters act throughout the body, and you may experience physical as well as mental effects when you stop taking antidepressants or lower the dose too fast. Common complaints include the following: Digestive. You may have nausea, vomiting, cramps, diarrhea, or loss of appetite.
A sudden change in dose of antidepressants can cause the serotonin levels to fall, producing withdrawal symptoms. Around 20% of people taking antidepressants experience withdrawal symptoms when they stop or reduce their dose. The symptoms are sometimes similar to those of depression.
When treatment is eventually stopped, there will be fewer receptors than before and a short-term deficiency of serotonin activity. The body will typically correct this, but there will be a period of adjustment until the system normalizes.
While antidepressants are generally intended to help with brain fog, some can cause brain fog as a side effect, depending on the medication and your unique response to it. Sedatives, pain medicine, bladder control medicine and antihistamines are some of the other types of medications that can lead to brain fog.
It's usually recommended that a course of antidepressants continues for at least 6 months after you feel better, to prevent your condition recurring when you stop. Some people with recurrent illness are advised to carry on taking medicine indefinitely.
Although this is beneficial for someone who's depressed, for someone who does not have depression, taking antidepressant medication can cause serotonin to build up in the body, resulting in serotonin syndrome. When serotonin levels are too high, the person may experience symptoms like: Agitation or restlessness.
Researchers conducted a meta-analysis of 17 studies comparing people using antidepressants to those on placebo. They found that those taking antidepressants were 33% more likely to die during the study time frame and 14% more likely to have a heart attack, stroke or other cardiovascular event.
A minimum of 3-6 months is required to restore neurotransmitter levels to normal. However, it takes longer to restore the body's total store of neurotransmitters. If a patient stops the neurotransmitter therapy too quickly, they may experience a return of their original symptoms.
The few studies of antidepressant withdrawal that have been published suggest that it is harder to get off some medications than others. This is due to differences in the drugs' half-life — the time it takes the body to clear the medication once the pills are stopped.
Brain zaps are sensory disturbances that feel like electrical shock sensations in the brain. They can happen when a person decreases or stops using certain medications, particularly antidepressants. Brain zaps are not harmful and will not damage the brain.
Your doctor might recommend stopping your antidepressant if: You're feeling better, and you and the doctor agree that it's time to stop. You have been taking the medicine for at least 6 months.
Antidepressant Discontinuation Syndrome Timeline
The symptoms typically last 1-3 weeks and will typically peak within the first week. Symptoms can be relieved within 24 hours by restarting the antidepressant medication.
At the end of 52 weeks of follow-up, 56% of the people who had been weaned off their antidepressant had relapsed into depression, compared to 39% of the people who continued their medications.