Iron deficiency is diagnosed when ferritin is <30μg/L in adults and < 20μg/L in children. When ferritin is not elevated as an acute phase reactant, a value >30μg/L is normal. Ferritin can be as high as 100μg/L in adults and 150μg/L in children with iron deficiency and inflammation.
The normal serum iron level for women is 60 mcg/dL to 140 mcg/dL. Total iron-binding capacity is 250 mcg/dL to 450 mcg/dL.
Although the transferrin level is increased, the serum iron level decreases; transferrin saturation decreases. Erythropoiesis is impaired when serum iron falls to < 50 mcg/dL (< 9 micromol/L) and transferrin saturation to < 16%.
Grading of anemia, according to the National Cancer Institute, is as follows: Mild: Hemoglobin 10.0 g/dL to lower limit of normal. Moderate: Hemoglobin 8.0 to 10.0 g/dL. Severe: Hemoglobin 6.5 to 7.9 g/dL[1]
Normal Results
Normal value range is: Iron: 60 to 170 micrograms per deciliter (mcg/dL), or 10.74 to 30.43 micromoles per liter (micromol/L) Total iron binding capacity (TIBC): 240 to 450 mcg/dL, or 42.96 to 80.55 micromol/L.
Iron deficiency is diagnosed when ferritin is <30μg/L in adults and < 20μg/L in children. When ferritin is not elevated as an acute phase reactant, a value >30μg/L is normal. Ferritin can be as high as 100μg/L in adults and 150μg/L in children with iron deficiency and inflammation.
If serum ferritin falls below 30µg/L (micrograms per litre), then iron stores are depleted (stage one or iron depletion). At serum ferritin levels less than about 20µg/L, the tissues and cells are not receiving the iron they need to function correctly (stage two or latent iron deficiency).
Undiagnosed or untreated iron-deficiency anemia may cause serious complications such as fatigue, headaches, restless legs syndrome, heart problems, pregnancy complications, and developmental delays in children. Iron-deficiency anemia can also make other chronic conditions worse or cause their treatments to work poorly.
Iron-Rich Foods
Heme iron is found in meat, fish and poultry. It is the form of iron that is most readily absorbed by your body. You absorb up to 30 percent of the heme iron that you consume. Eating meat generally boosts your iron levels far more than eating non-heme iron.
You may also find that low iron causes weight gain. There are a couple of reasons for this; firstly, your energy levels are low and so your exercise levels reduce; secondly, iron is essential for thyroid function, and an underactive thyroid will lead to weight gain.
Common causes of iron deficiency include not getting enough iron in your diet, chronic blood loss, pregnancy and vigorous exercise. Some people become iron deficient if they are unable to absorb iron. Iron deficiency can be treated by adding iron-rich foods to the diet.
– It usually takes 2 to 3 weeks of taking regular iron supplements before your symptoms start to improve. – You may need to keep taking iron for several months to build up your iron reserves and keep your anemia from returning. Take your pills for as long as your doctor recommends, even if your symptoms have improved.
Another measurement, called transferrin saturation, checks how many places on your transferrin that can hold iron are actually doing so. Normal values are 15% to 50%. In severe cases of iron-deficiency and anemia, this number may fall below 10%.
How much iron do women need? For women, the normal hemoglobin range is generally defined as 12.0 to 15.5 grams of hemoglobin per deciliter of blood.
The WHO defines low ferritin as levels <15 μg/L for adults and <12 μg/L for children. However, in clinical practice, when ferritin levels dip below 30 μg/L, ID can be ascertained. Ferritin is an acute-phase reactant that is increased in serum during chronic inflammation.
If left untreated, iron-deficiency anemia can cause serious health problems. Having too little oxygen in the body can damage organs. With anemia, the heart must work harder to make up for the lack of red blood cells or hemoglobin. This extra work can harm the heart.
"Iron deficiency often causes only mild symptoms, but — left undiagnosed and untreated — it can affect a person's quality of life and, while rare, even be a sign of a serious health issue."
Your body relies on iron to make hemoglobin, so when iron is low, you can become anemic. Your cells don't receive enough oxygen, and you feel tired. “The most frequent symptom of iron-deficiency anemia is fatigue,” says Kathryn Boling, MD, a family doctor at Mercy Medical Center in Baltimore.
Eye symptoms of low iron can include a pale coloring of the inside of the lower eyelids. In moderate or severe cases of iron deficiency anemia, the inside layer of the lower eyelid is very pale pink or yellow instead of red. Rather than low iron, one common cause of blurry vision is dry eye.
Normal levels are generally between 35.5 and 44.9 percent for adult women and 38.3 to 48.6 percent for adult men. These values may change depending on your age. Hemoglobin. Lower than normal hemoglobin levels indicate anemia.
Your body can't absorb iron.
Conditions like celiac disease,ulcerative colitis, or Crohn's disease can make it harder for your intestines to absorb iron. Surgery such as gastric bypass that removes part of your intestines, and medicines used to lower stomach acid can also affect your body's ability to absorb iron.
About 25% of iron deficient subjects have a serum ferritin in the range of 16–30 µg/l. some argue that levels below 40–45 µg/l represent a state of iron shortage and should be actively treated.