Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.
Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. Bone pain from Prolia may be most noticeable in your arms and legs.
However, it carries a risk of serious side effects. People with weakened immune systems are advised not to use to denosumab because it can lead to serious infections that require hospitalization (such as heart infections). It can also cause disintegration of the jaw, called osteonecrosis, and atypical femur fractures.
Adverse reactions reported in ≥ 10% of Prolia-treated patients receiving ADT for prostate cancer or adjuvant AI therapy for breast cancer, and more frequently than in the placebo-treated patients were: arthralgia (13.0% placebo vs. 14.3% Prolia) and back pain (10.5% placebo vs. 11.5% Prolia).
Dental side effect of receiving Prolia
Prolia has a side effect in patients who have to have tooth extractions performed. The trauma of the extraction on the bone surrounding the tooth may lead to a condition where the bone dies off, and following the extraction fragments of dead bone are lost from the extraction site.
Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.
The majority of commercial and Medicare plans cover Prolia®. The list price for Prolia® is $1,564.31 †,‡ per injection every six months.
Official answer. Yes, Prolia (denosumab) does increase bone density. Research has shown that Prolia significantly increased bone mineral density (BMD) by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia.
It should only be used if other treatment methods have failed or by post-menopausal women who have severe osteoporosis. The National Women's Health Network suggests women try other FDA-approved osteoporosis medications prior to trying Prolia.
Other bisphosphonates besides Reclast: Examples of others include ibandronate (Boniva) and alendronate (Fosamax). Raloxifene (Evista): Raloxifene changes the way your body processes estrogen, and is therefore used to prevent or treat osteoporosis in women after menopause.
muscle and joint pain. stomach and back pain, nausea, vomiting and/or sweating. Rarely denosumab may cause an allergic reaction with a widespread rash or a feeling of tightness in the chest and difficulty breathing. A very rare side effect with denosumab is osteonecrosis of the jaw (ONJ).
How long can I stay on Prolia for? For Prolia to work well at reducing fractures it needs to be taken long term and in one phase 2 clinical trial it has been used safely for up to 8 years with substantial increase in bone density, although most clinical trials are for 3 or 4 years.
Drug regulators in Australia are warning that the bone drugs Prolia and Xgeva, both of which use the active ingredient denosumab and are also available in the United States, could cause users to suffer abnormal heart rhythms linked to lowered calcium levels.
However, both Dr. Adachi and Amgen state that serious side effects are rare. Dr. Adachi's experience is that most side effects last a short time (less than 3 months), and many Prolia side effects can be treated and reversed.
Osteoporosis is not a terminal illness and does not directly influence life expectancy. However, having a fracture can affect it. For example, a 2021 study found that older adults living in a care facility who experienced a hip fracture had a 25% death rate after 3 months.
Osteoporosis is not reversible, but medication, a nutrient-dense diet, and weight bearing exercise can help prevent further bone loss and rebuild bones.
Prolia (denosumab) is a convenient option for treating osteoporosis, because you only need 1 injection of the medication every 6 months. It works well to strengthen your bones, but Prolia (denosumab) can cause serious side effects, such as low calcium levels, broken thigh or spine bones, and infections.
Bisphosphonates. For both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates.
Several natural interventions promote increased bone health. These include sufficient consumption of bone-supportive nutrients through healthy eating and nutritional supplements, including calcium, magnesium, vitamin D, boron, strontium, soy isoflavones, and vitamin K.