1 Day – On the first day of taking an antidepressant medication, most people will feel nothing at all. Some will notice side effects like nausea or vomiting that could be mild. 1 Week – One week in, people are more likely to note some other side effects like sleeping problems, diarrhea, dry mouth, and sexual problems.
Most antidepressants don't work right away. Or at least, you may not notice the changes right away. Many of them, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), generally take about 2 to 8 weeks to work.
Some people say they notice an immediate benefit or improvement in their mood, and experience few, if any, side effects when they start to take an antidepressant for the first time.
Antidepressants usually need to be taken for 1 or 2 weeks (without missing a dose) before the benefit starts to be felt. It's important not to stop taking them if you get some mild side effects early on, as these effects usually wear off quickly.
SSRIs are usually the first choice medicine for depression because they generally have fewer side effects than most other types of antidepressant. As well as depression, SSRIs can be used to treat a number of other mental health conditions, including: generalised anxiety disorder (GAD)
Ketamine. Ketamine is a medication originally used for anesthesia and pain relief, but medical professionals also use it to help people with treatment-resistant depression. Unlike other antidepressants, ketamine can improve depression symptoms in just a few hours.
SSRIs release two chemicals in the brain that kick in at different times, causing a period of negative effects on mental health, the authors report. The first chemical is serotonin, which is released very soon after an SSRI is taken but might not lessen depressive symptoms until after a couple of weeks.
In terms of how they make a person feel, antidepressants may have a number of positive effects. “The person taking the antidepressant has increased energy and is calmer,” Dr. McGee says. “They have improved motivation and their sleep and appetite are better regulated.
Antidepressants can make you feel worse at first
But it can cause side effects that are very similar to depression. Antidepressants can make you feel tired, cause concentration problems, and lead to changes in sleep and appetite.
Antidepressants don't have the euphoric effects other drugs have. In other words, Antidepressants can't get the user high. That doesn't stop some people from trying, though. Some people think since Antidepressants improve mood that high doses must induce euphoria, but that is not how the drugs work.
Although this is beneficial for someone who's depressed, for someone who does not have depression, taking antidepressant medication can cause serotonin to build up in the body, resulting in serotonin syndrome. When serotonin levels are too high, the person may experience symptoms like: Agitation or restlessness.
In the early days of treatment, it can increase levels of fear and anxiety and even suicidal thinking in some younger people. As a result, patients may stop using the treatment after a few weeks.
They will help you feel like yourself again and return to your previous level of functioning. (If a person who isn't depressed takes antidepressants, they do not improve that person's mood or functioning - it's not a "happy pill.") Rarely, people experience apathy or loss of emotions while on certain antidepressants.
You may also experience some side effects when you first start taking antidepressants, but feel them less after a few weeks.
They take a while to work. When you first start taking an antidepressant medicine, you won't feel better straight away. Most people start to feel better after taking them for 2 to 4 weeks. But it can take up to 6 to 8 weeks for them to really work.
While some researchers have indeed attributed improved symptoms associated with depression to personality changes, other experts have been skeptical that drugs such as SSRIs have independent effects on personality. They attribute changes to a patient's improved mood.
If you are worried about these or other side effects talk to your doctor. When you start an antidepressant medicine, you may feel worse before you feel better.
You may experience side effects during your first week on Lexapro, including anxiety, difficulty sleeping, drowsiness, headaches, and nausea. These effects usually dissipate as your body adjusts to your medication.
1 Day – On the first day of taking an antidepressant medication, most people will feel nothing at all. Some will notice side effects like nausea or vomiting that could be mild. 1 Week – One week in, people are more likely to note some other side effects like sleeping problems, diarrhea, dry mouth, and sexual problems.
Antidepressants may take a while to kick in. You may feel some depression symptoms improve within the first couple weeks, but it can often take 4 to 8 weeks to feel the full effects of your medication. If you've taken your antidepressant for at least 4 weeks with no improvement, let your healthcare provider know.
It's not clear exactly how Zoloft causes sleepiness, but it's thought that the drug's effects on serotonin levels in the brain may play a role. Serotonin is involved in the regulation of sleep, and increasing serotonin levels with an SSRI like Zoloft may lead to drowsiness.
Antidepressants are usually taken in tablet form. Depending on the type of antidepressant prescribed and the severity of your depression, you may have to take 1 to 3 tablets a day. It usually takes around 7 days before you begin to notice the effects of antidepressants.
SSRIs are the most commonly prescribed class of antidepressants. This is because they're effective and well-tolerated antidepressants with little side effects. With many SSRIs available as generic products, this medication class typically costs less. SNRIs and bupropion are also common choices for similar reasons.
Overall, citalopram appears to be the best-tolerated SSRI, followed by fluoxetine, sertraline, paroxetine, and fluvoxamine. The latter 2 drugs are associated with the most side effects and the highest discontinuation rates because of side effects in clinical trials.