In multiple sclerosis (MS), chronic neuropathic pain is one of the most frequent symptoms that dramatically reduces the quality of life of MS patients. Current treatment strategies include antidepressants, anticonvulsants, and cannabinoid drugs.
Surveys for patient pain indicate that the most common pain syndromes experienced in MS are: continuous burning in extremities; headache; back pain; and painful tonic spasms.
MS can damage the nerves that affect your muscles. This can cause acute or paroxysmal pain in the form of spasms. Your arms and legs might shoot out uncontrollably and might have pain like cramping or pulling. Nerve pain can also be chronic in the form of painful or unusual sensations on your skin.
Chronic neuropathic pain
In MS these pains can be experienced on a daily or nearly daily basis and often it is unpredictable when they will occur. If you have experienced an acute neuropathic pain before it's possible for it to become a chronic neuropathic pain.
Dr. Cross notes that these drugs include the anticonvulsants Neurontin (gabapentin), Tegretol (carbamazepine), and Dilantin (phenytoin), as well as the tricyclic antidepressant amitriptyline. For spasticity, the drugs baclofen and Zanaflex (tizanidine) can greatly reduce painful cramping and other symptoms.
Natalizumab (Tysabri).
This medication is designed to block the movement of potentially damaging immune cells from your bloodstream to your brain and spinal cord. It may be considered a first line treatment for some people with severe MS or as a second line treatment in others.
Multiple sclerosis (MS) triggers that worsen symptoms or cause a relapse can include stress, heart disease and smoking. While some are easier to avoid than others, maintaining a healthy lifestyle and overall health and wellness can have outsized benefits for MS patients.
MS symptoms that tend to be a greater problem at night include: Muscle spasms and stiffness: Movement throughout the day can help to loosen muscles and bring relief, but they get worse again during sleep when they are still.
A recent study of 5,300 people with MS found that more than half of participants reported fatigue, tingling and numbness, cognitive issues, muscular weakness, pain, and depression.
Abnormal sensations can be a common initial symptom of MS. This often takes the form of numbness or tingling in different parts of your body, such as the arms, legs or trunk, which typically spreads out over a few days.
Early MS symptoms may include blurred vision, numbness, dizziness, muscle weakness, and coordination issues. MS is progressive and can worsen over time. Eventually, the disease can do damage directly to the nerves, causing permanent disability.
Lesions in the brain may affect cognitive abilities. Some people with MS have trouble with memory, attention and concentration, multitasking and decision-making, says Dr. Scherz. The changes are usually mild at the beginning, but can be frustrating as time goes by.
What do MS attacks feel like? MS attack symptoms vary, including problems with balance and coordination, vision problems, trouble concentrating, fatigue, weakness, or numbness and tingling in your limbs.
These include fibromyalgia and vitamin B12 deficiency, muscular dystrophy (MD), amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), migraine, hypo-thyroidism, hypertension, Beçhets, Arnold-Chiari deformity, and mitochondrial disorders, although your neurologist can usually rule them out quite easily.
People should consider the diagnosis of MS if they have one or more of these symptoms: vision loss in one or both eyes. acute paralysis in the legs or along one side of the body. acute numbness and tingling in a limb.
“Fulminate MS” is a rapidly progressive disease course with severe relapses within five years after diagnosis; also known as “malignant MS” or “Marburg MS,” this form of very active MS may need to be treated more aggressively than other forms.
Increased napping during the day due to fatigue. Reduced physical activity due to fatigue and MS-related disability. Emotional changes including stress, anxiety or depression. Other MS symptoms including restless legs, pain, urinary or bowel symptoms, and temperature dysregulation.
A person with benign MS will have few symptoms or loss of ability after having MS for about 15 years, while most people with MS would be expected to have some degree of disability after that amount of time, particularly if their MS went untreated.
Most MS exacerbations last from a few days to several weeks or even months.
For instance, MS symptoms such as depression, being in pain or by having sleep disturbed by spasms or needing to go to the toilet more often can all make fatigue worse. Fatigue may also occur as a side effect of various medications or be the result of inactivity, stress, poor diet or an infection.
The 'MS hug' is symptom of MS that feels like an uncomfortable, sometimes painful feeling of tightness or pressure, usually around your stomach or chest. The pain or tightness can stretch all around the chest or stomach, or it can be just on one side. The MS hug can feel different from one person to another.
Over-the-counter pain relievers such as nonsteroidal anti-inflammatory drugs (NSAIDs), like Aleve (naproxen) and Advil (ibuprofen), can treat musculoskeletal pain and headaches common with MS. These medications can relieve pain and lower inflammation in the body, which can also help with the pain associated with MS.