Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body. H1R are expressed in many cells, including mast cells, and are involved in Type 1 hypersensitivity reactions.
The most common cause of acute histamine toxicity is the result of inadequate refrigeration or spoiled fish. This causes an overgrowth of bacteria which converts histidine to high levels of histamine. Individuals who have unusually low levels of the enzyme diamine oxidase may be more susceptible to histamine toxicity.
This includes aged cheeses, canned fish, fermented food (like kombucha or kimchi), yeast or yeast extract, processed meats, and alcohol. Anecdotally, Dr. Burkhart also says strawberries and citrus are high in histamines.
Vitamin C is a natural antihistamine, which means it can lower histamine levels and mitigate allergic reactions and symptoms. Consume plenty of Vitamin C rich foods, like tropical fruits, citrus fruits, broccoli and cauliflower, and berries.
The best way to clear histamine from the body is to start an elimination diet that involves only eating and drinking substances that contain low amounts of histamine.
Nettles. Nettle leaf is a natural antihistamine that naturally blocks histamine production. It can be made in to a tincture or tea, but for allergy relief, capsules made from dried nettle leaves are the most effective option.
Caffeine Intolerance: Symptoms of Coffee Allergies
Coffee is high in histamine which can set off what looks like an allergic reaction but it doesn't occur through the typical allergy mechanism. Instead, the histamine from the coffee causes an inflammatory reaction that can be quite severe in some people.
If you have a food allergy, histamines are in on that response process, too. When you accidentally eat or drink something you shouldn't, they'll work in your gut to trigger your allergic reaction. Some foods are also naturally high in histamines. These include aged and fermented foods and alcohol (especially red wine).
Eggs are likely suitable for a low histamine diet. Egg yolks are low histamine, and egg whites, while traditionally thought of as being histamine liberators, are likely friendly for a low histamine diet as well.
Avocados are naturally very high in histamine and such high levels can be problematic for people with histamine intolerance. If you suspect that you may have histamine intolerance, it is best to avoid foods high in histamine, such as avocados.
Histamine release is stimulated by gastrin, vasoactive intestinal peptide, ghrelin, acetylcholine, and epinephrine through receptor-ligand interactions on ECL cells.
Certain amines and alkaloids, including such drugs as morphine, and curare alkaloids, can displace histamine in granules and cause its release. Antibiotics like polymyxin are also found to stimulate histamine release. Histamine release occurs when allergens bind to mast-cell-bound IgE antibodies.
Histamine-releasing neurons are located exclusively in the TM of the hypothalamus, from where they project to practically all brain regions, with ventral areas (hypothalamus, basal forebrain, amygdala) receiving a particularly strong innervation.
Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.
Vitamin C acts as a natural antihistamine by reducing the amount of histamine your body produces in response to an allergen. It might help reduce mild symptoms like sneezing, runny nose, congestion, and watery eyes due to allergic rhinitis.
Citrus Fruits – Vitamin C (ascorbic acid) is an antioxidant that prevents oxidative stress in the body and is also a natural antihistamine. Consuming adequate amounts of Vitamin C from citrus fruits such grapefruits, oranges, lemons and kiwis can also help fight infections.
Because dehydration can influence the body's natural histamine response, making sure you drink enough water can be an effective way to help keep your histamine response in check.
High blood histamine levels will cause chronic health conditions, which could be lifelong. In contrast a true food "allergy" results in symptoms within a few minutes like lip swelling, itchiness, sneezing, hives, diarrhea and possibly anaphylaxis.
Bananas are not directly high in histamine, but many people have reported that bananas are still a trigger for their histamine intolerance symptoms. Such a food is known as a “histamine liberator,” and should therefore be treated like a high histamine food.
Potatoes do not have a high histamine content and do not increase the body's histamine burden. Therefore, most people with histamine intolerance can eat them safely. You can also eat potatoes with additional food sensitivities, such as gluten sensitivity.
Low Histamine Foods
Fruit: blueberries, apricots, cranberries, apples, mango, peaches. Vegetables: Onion, sweet potatoes, asparagus, broccoli, squash, cucumbers, beets. Fats and Oils: animal fats.
Broccoli is likely suitable for a low histamine diet. Broccoli is likely low in histamine and other amines and does not trigger release of the body's natural histamine.