Selective serotonin reuptake inhibitors (SSRIs) with a lower risk of liver injury include fluoxetine, paroxetine, citalopram, and escitalopram.
The best antidepressant options for patients with liver failure is desvenlafaxine. This drug is an active metabolite of venlafaxine, with high percentage of unchanged metabolites eliminated in the urine.
Damage may take place within days or up to six months after beginning an antidepressant. The antidepressants that pose the highest risk of liver damage, the investigators concluded, include monoamine oxidase (MAO) inhibitors, tricyclic/tetracyclic antidepressants, nefazodone, bupropion, duloxetine and agomelatine.
Lorazepam is metabolized by the liver to inactive metabolites and is considered the benzodiazepine best tolerated by patients with advanced liver disease.
The liver digests Zoloft. If the liver is not functioning well, more Zoloft remains in the person's bloodstream. People with liver failure can take Zoloft, but doctors may need to adjust the dosage. If someone has mild liver failure, the doctor will prescribe half the usual dosage, for example.
Selective serotonin reuptake inhibitors (SSRIs) with a lower risk of liver injury include fluoxetine, paroxetine, citalopram, and escitalopram. One concern when using SSRI in patients with liver disease is its association with GI bleeding, and the extent of risk of bleeding in those with liver disease.
The antidepressants that seem to have the least potential for hepatotoxicity are citalopram, escitalopram, paroxetine, and fluvoxamine.
Venlafaxine, sold as Effexor, is the most common SNRI prescribed by doctors in Australia. Medications managing two chemicals in the brain, as SNRIs do, are more likely to come with side effects, Dr Eapen says.
1. Celexa. Overall, Celexa seems to be one of the best-tolerated SSRIs for many people. It tends to cause less weight gain and may have a lower risk of causing insomnia than some SSRIs.
SSRIs are usually the first choice medicine for depression because they generally have fewer side effects than most other types of antidepressant.
Although thought to be generally safe and with minimal drug-drug interactions, clinicians should be aware of the possibility of escitalopram-induced liver injury when initiating depressed patients on antidepressant treatment. This requires extra vigilance as most patients may remain asymptomatic.
Fluoxetine, paroxetine, sertraline, citalopram, and fluvoxamine are SSRIs mostly linked with hepatotoxicity (Table
Tricyclic antidepressants — such as imipramine, nortriptyline (Pamelor), amitriptyline, doxepin and desipramine (Norpramin) — tend to cause more side effects than newer antidepressants.
French fries, wafers, burgers, and pizzas do no good to your liver. These food items are high in saturated fat or trans-fat content and are difficult to digest. In other words, your liver needs to work hard to process these food items.
Magnesium supplementation can not only preserve liver function, but also slow the progression of liver disease, and reduce the mortality associated.
SSRI's are anti-depressants and are currently the most popular anti-depression / anti-anxiety drugs as they have fewer side effects than MAOI's. SSRI's include drugs such as Prozac, Luvox and Aropax. SSRI's must be taken on a daily basis for at least a few weeks before they are effective.
Selective Serotonin Reuptake Inhibitors (SSRIs)
This class includes sertraline, citalopram, escitalopram, paroxetine, fluoxetine and fluvoxamine. SSRIs are: the most commonly prescribed antidepressants in Australia. often a doctor's first choice for most types of depression.
The antidepressants most widely prescribed for anxiety are SSRIs such as Prozac, Zoloft, Paxil, Lexapro, and Celexa. SSRIs have been used to treat generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, and post-traumatic stress disorder.
Lexapro is the cleanest SSRI at targeting the serotonin system with minimal effect on other unwanted targets in the body.
SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline. [16] These have the lowest potential for drug-drug interactions based on their cytochrome P-450 interactions.