I also recommend some simple and usually safe over-the-counter treatments such as melatonin or chamomile.
I recommend some routine steps for treating insomnia, such as avoiding bright lights, including any electronic screen, for two hours or so before bed; regular exercise, if the condition for which you took prednisone allows it; and a warm bath before bed.
Sleep disturbance: Prednisone keeps some people awake. This is because it affects the hormones that help you feel energized (cortisol) and sleepy (melatonin). So it's common for people to report difficulty sleeping while they're taking prednisone.
Steroids and immunosuppressant medications.
Melatonin may cause these medication to lose their effectiveness. DO NOT take melatonin with corticosteroids or other medications used to suppress the immune system.
While prednisone is not a stimulant, it can make you feel more alert or jittery. “It doesn't really interrupt sleep, but some patients find it keeps them awake when they don't want to be,” Dr. Ford says. What you can do: “If it's possible, we recommend you take your whole dose in the morning,” he recommends.
Take prednisolone with breakfast so it does not upset your stomach. Taking prednisolone in the morning also means it's less likely to affect your sleep. If your prednisolone tablets are labelled as "enteric coated" or "gastro resistant", you can take these with or without food but make sure to swallow them whole.
Not only does taking prednisone at bedtime work better, the newly available delayed-release formula (Rayos, Horizon Pharma) takes effect at 3 a.m., when it is needed the most, he says. Studies as far back as 1964 have documented the advantages of treating inflammation at night.
Some products that may interact with this drug include: aldesleukin, mifepristone, drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as dabigatran/warfarin, NSAIDs such as aspirin/celecoxib/ibuprofen).
Prednisone has a tendency to raise the level of glucose, or sugar, in the blood, which can cause increased body fat or diabetes in some people. It is important to avoid "simple" carbohydrates and concentrated sweets, such as cakes, pies, cookies, jams, honey, chips, breads, candy and other highly processed foods.
Some key drugs that interact with steroids include anticoagulants (such as warfarin), drugs for blood pressure, antiepileptics, antidiabetic drugs, antifungal drugs, bronchodilators (such as salbutamol) and diuretics.
Prednisone side effects are common and can include insomnia, abnormal hair growth, fatigue, thinning of the skin, constipation, and more. 1 While some are manageable, others can be intolerable or even permanent.
Prednisone generally works very quickly — usually within one to four days — if the prescribed dose is adequate to reduce your particular level of inflammation.
Steroids do not tend to cause significant side effects if they're taken for a short time or at a low dose. But sometimes they can cause unpleasant side effects, such as an increased appetite, mood changes and difficulty sleeping (insomnia). This is most common with steroid tablets.
No interactions were found between Equate Sleep Aid and prednisone. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
“If corticosteroids are to blame, gradually tapering off them can help with weight loss and facial swelling,” Dr. Guo said. “You'll take less and less until your body adjusts, and you might be able to safely stop the steroid. You need to have normal adrenal gland function before you stop long-term steroids.”
Prednisone affects areas of the brain that manage the regulation of different neurotransmitters, including serotonin and dopamine — the “feel-good” hormones. Feeling happy is a great side effect some people feel with prednisone.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects. Take this medicine with food or milk to avoid stomach irritation.
Also, increase your intake of low-fat foods that have high calcium levels. Some of these include corn, sardines, almonds, broccoli, milk, yogurt, cheese, tofu, cooked soybeans, boiled white beans, and salmon.
Steroids may increase your risk of developing ulcers or gastrointestinal bleeding, especially if you take these medications along with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or aspirin. If at all possible, don't combine steroids with NSAIDs.
Generally speaking, it's safe to take prednisone with Tylenol because no known drug interactions or drug and food interactions have been found. Always consult with your healthcare provider to discuss their recommendations.
People taking prednisone can also experience higher blood sugar, which is a special concern for those with diabetes. Because prednisone suppresses the body's immune system, it can also increase the risk of infection.
Some side effects, such as stomach upset or mood changes, can happen straight away. Others, such as getting a rounder face, happen after weeks or months.
It takes approximately 16.5 to 22 hours for Prednisone to be out of your system. The elimination half life of prednisone is around 3 to 4 hours.
The good news is that if you're taking this medication for a short time — say, less than 5 days — you'll likely have few, if any, side effects, says Soliman. There's no limit on how long you can take prednisone.