If left untreated, the disease can lead to death. If you decline life-saving treatment, you can choose to get support from palliative care (a medical team that manages your symptoms and pain). Later, hospice can support you in the final months to help you manage your quality of life.
"About half of all patients can put off treatment for at least 3 years," Abetti says. "Some patients can be in watch-and-wait mode for 10 years or more." It's possible you'll never need treatment. There's no way to know for sure if you'll eventually need treatment.
Low-Grade Lymphoma
These grow so slowly that patients can live for many years mostly without symptoms, although some may experience pain from an enlarged lymph gland. After five to 10 years, low-grade disorders begin to progress rapidly to become aggressive or high-grade and produce more severe symptoms.
You can have lymphoma for years without noticing changes in your body. Sometimes, people learn they have the condition of lymphoma because routine imaging tests detect signs of lymphoma.
Burkitt lymphoma grows very rapidly, which means that symptoms usually develop quickly, over just a few days or weeks. The most common symptom is one or more lumps, which often develop in several parts of your body. These are swollen lymph nodes.
Stage 4. Stage 4 is the most advanced stage of lymphoma. Lymphoma that has started in the lymph nodes and spread to at least one body organ outside the lymphatic system (for example, the lungs, liver, bone marrow or solid bones) is advanced lymphoma.
Stage 4 lymphoma means that cancer has spread to an organ external to the lymphatic system. The survival rates vary widely depending on an individual's risk factors and type of cancer. The survival rate of stage 4 lymphoma is lower than that of the other stages, but doctors can cure the condition in some cases.
There is a chance that your treatment can increase the risk of getting another type of cancer in the future. This is because both chemotherapy drugs and radiotherapy work by damaging cells. They kill the lymphoma cells, but they can damage healthy cells too.
Blood tests are not used to diagnose lymphoma, but they can sometimes help determine how advanced the lymphoma is.
Certain areas of skin may also thicken, harden and form plaques that itch and ulcerate. Typically, these plaques develop on the face or buttocks or within skin folds. As a skin lymphoma rash progresses, papules (small bumps) may start to appear.
(See 'Symptoms' above.) The progression of follicular lymphoma varies from one person to another, depending on the speed of the tumor's growth and the involvement of other organs. Sometimes, people with follicular lymphoma have no symptoms for many years and do not need treatment.
The new immune cells can recognise lymphoma cells as foreign and help to get rid of them. Targeted treatments that help your immune system to recognise and attack lymphoma cells (such as checkpoint inhibitors).
Follicular lymphoma may go away without treatment. The patient is closely watched for signs or symptoms that the disease has come back. Treatment is needed if signs or symptoms occur after the cancer disappeared or after initial cancer treatment.
Common symptoms of having lymphoma include swelling of lymph nodes in your neck, in your armpits or your groin. This is often but not always painless and often could be associated with fevers, or unexplained weight loss, or drenching night sweats, sometimes chills, persistent fatigue.
The most common sign of lymphoma is a lump or lumps, usually in the neck, armpit or groin. These lumps are swollen lymph nodes, sometimes known as 'glands'. Usually, they're painless. Fatigue is different to normal tiredness.
you develop 'B symptoms' (night sweats, weight loss and fevers) your lymph nodes or spleen start to grow quickly or you develop swollen lymph nodes in new places. your blood tests or other test results show that lymphoma is affecting your major organs or is growing in your bone marrow.
The most common sites are in the chest, neck, or under the arms. Hodgkin lymphoma most often spreads through the lymph vessels from lymph node to lymph node. Rarely, late in the disease, it can invade the bloodstream and spread to other parts of the body, such as the liver, lungs, and/or bone marrow.
The changes can be gradual, but crises can develop. People with NHL most often die from infections, bleeding or organ failure resulting from metastases.
The lymphatic system runs throughout your whole body. So you can get lymphoma just about anywhere including the brain and the spinal cord. Most lymphomas of the brain start in the front part of the brain (the cerebrum).
Whether your lymphoma is being treated or not, it's important to have treatment to relieve your symptoms. This type of treatment, sometimes called palliative care, can be given along with cancer treatment as well as if cancer treatment is no longer working.
Lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia.
This is a rare, slow-growing type of lymphoma. It's found mainly in the bone marrow, lymph nodes, and spleen. This type of lymphoma can't be cured. But people can live with it for many years.
As the disease progresses and moves to stage 4 – it means that lymphoma has been found in lymph nodes on both sides of the body and has metastasized to distant organs. Its most frequent sites of spread include the liver, bone marrow, and lungs. With that, symptoms of dysfunction in those systems may be apparent.