The results of this study clearly demonstrate that patients with typical reflux symptoms who have failed twice-daily PPI therapy and have a well-defined diagnosis of hypersensitive esophagus will benefit from treatment with citalopram.
Furthermore, antidepressants reduced functional chest pain by 18% to 67% and reduced heartburn in patients with GERD by 23% to 61%.
Medications and dietary supplements that can increase acid reflux and worsen GERD include: Anticholinergics, such as oxybutynin (Ditropan XL), prescribed for overactive bladder and irritable bowel syndrome. Tricyclic antidepressants (amitriptyline, doxepin, others)
Prozac is also the SSRI that is least likely to cause nausea and stomach upset. There's also some weak evidence that Prozac is less likely to cause sexual side effects.
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They can ease symptoms of moderate to severe depression, are relatively safe and typically cause fewer side effects than other types of antidepressants do.
SSRIs are usually the first choice medicine for depression because they generally have fewer side effects than most other types of antidepressant.
Amitriptyline (Vanatrip, Endep), imipramine (Tofranil), and nortriptyline (Pamelor, Aventyl) are among the tricyclic antidepressants that can cause acid reflux.
Trials of citalopram and escitalopram were associated with reports of persistent nausea and gastric reflux unresolved by changes in dosing schedule or positioning. Over-the-counter omeprazole on an as-needed basis was added.
Research shows that people who report depression and anxiety are more sensitive to reflux. Everybody gets heartburn from time to time. But if it becomes chronic — defined as two or more times per week — you may have gastroesophageal reflux disease (GERD).
Dexlansoprazole MR (30 mg daily for 4 weeks) provides significantly better symptom control as compared with placebo. Furthermore, the drug is more efficacious than placebo in relieving nocturnal heartburn and reducing GERD-related sleep disturbances when given in a dose of 30 mg daily for a period of 4 weeks.
Proton pump inhibitors are widely recognized as the most effective agents for treating GERD.
The researchers found that at the end of the study, only 23% of those on citalopram still had reflux symptoms, compared with 67% of those on placebo, which was significantly different (P=0.047). "The results show that treatment with SSRI is effective for patients with hypersensitive esophagus," Viazis said.
Background: Esophageal hypersensitivity is considered an important pathophysiological mechanism in refractory gastroesophageal reflux disease (GERD) patients. Serotonin (5-HT) plays an important role in the regulation of GI (gastrointestinal) secretion, motility and sensitivity.
However, these symptoms are sometimes difficult to control, even with the most potent proton-pump inhibitors (PPIs), and these patients tend to have a lower response rate. According to the clinical data, Anxiety and Depression are linked to the development of GERD.
Escitalopram is not approved for use by anyone younger than 12 years old. Ask your doctor about taking this medicine if you are pregnant. Taking an SSRI antidepressant during late pregnancy may cause serious medical complications in the baby.
You may also experience some indigestion and constipation because most serotonin receptors are in the GI tract and the use of SSRIs can disrupt normal digestive functioning, adds Dr. Kastenberg. To soothe your stomach, take Lexapro with food.
Nausea is one of the most common side effects of Lexapro. In clinical studies, up to 18% of people taking Lexapro experienced nausea. Luckily, nausea is a side effect that may improve over time as your body gets used to the medication. Lexapro can be taken with or without food.
Among patients with depression, tricyclic antidepressant use was associated with an increased risk of GERD (OR: 1.71; 95% CI: 1.34–2.20), while selective serotonin reuptake inhibitors were not associated with GERD.
There is some evidence to suggest that stress and anxiety may provoke acid reflux or make the symptoms worse. For instance, a 2018 study involving more than 19,000 people found that those with anxiety were more likely to experience GERD symptoms.
Yes, you can take Gaviscon® with other medications. Similar to antacids, however, Gaviscon® should not be taken within 2 hours of other medications.
SSRIs are the most widely prescribed type of antidepressants. They're usually preferred over other antidepressants, as they cause fewer side effects.
SSRIs and SNRIs are often the first-line treatment for anxiety. Common SSRI brands are Celexa, Lexapro, Luvox, Paxil, and Zoloft. Common SNRI brands are Pristiq, Cymbalta, and Effexor XR. Pros: They are effective for a lot of people and they have a solid safety profile.