If you have a breeding dog, a pregnant dog, or a puppy between 6 and 8 weeks old, Heartgard Plus is the safest option. If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner.
As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
First of all, the key difference is that Simparica is an oral flea and tick treatment that kills both ticks and fleas. In contrast, Heartgard Plus kills roundworms and hookworms, and it protects your dog against heartworms.
Bravecto kills many types of ticks including the lone star tick for 8 weeks. Simparica's active ingredient, Sarolaner, begins to kill fleas within 3 hours and ticks within 8 hours. When considering time to efficiency between these two, we'll consider it a tie.
If you have a breeding dog, a pregnant dog, or a puppy between 6 and 8 weeks old, Heartgard Plus is the safest option. If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner.
Melarsomine. Melarsomine is the only FDA-approved adulticide therapy for heartworm disease. The AHS-recommended protocol, which is considered safer and more effective than alternative protocols, consists of an initial injection followed one month later by two injections spaced 24 hours apart.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
How does Simparica Trio work? Simparica contains three active substances: sarolaner, moxidectin and pyrantel. Sarolaner acts as an 'ectoparasiticide'. This means that it kills parasites present on the skin or in the fur of animals, such as fleas and ticks.
Simparica Trio should be used with caution in dogs with a history of seizures. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders.
Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs).
Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 ...
Heartworm Prevention
In two well‑controlled laboratory studies, a single oral dose of SIMPARICA TRIO was 100% effective in preventing the development of adult D. immitis in dogs inoculated with infective larvae 30 days before treatment.
Trifexis is one of the leading oral combination heartworm preventatives. It is a once a month chewable tablet that prevents heartworms, kills adult fleas and also prevents hookworms, roundworms and whipworms. Sentinel Spectrum does the same, with the added benefit of preventing tapeworms.
Simparica protects against more varieties of ticks than Bravecto does and also offers a variation that protects against worms. Bravecto is effective for three times longer (12 weeks), while Simparica must be reapplied monthly. Each medication will require a prescription from your vet.
Results: Simparica Trio was generally well tolerated. Emesis occurred at low frequency in all groups including control. Abnormal stool occurred occasionally in the 1× and 3× groups throughout the 3-month study.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.
Monthly Simparica protects dogs from ticks and fleas for 35 days. Have you ever been a few days late giving your dog monthly tick and flea protection? We get it.
Side Effects & Warnings
Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications.
Side effects
Simparica for dogs is a drug from the isoxazoline class. This class has been linked to neurological signs such as tremors, unsteadiness, and seizures in dogs. However, the FDA considers drugs in the isoxazoline class to be safe and effective for dogs.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio. But while Simparica is usually safe flea and tick treatment for dogs, it shouldn't be prescribed to dogs with a history of seizures.
Nuheart is a generic Heartgard alternative that aids in the prevention of heartworms in dogs. It eliminates heartworm larvae that infect the dog the previous month, thus protecting dogs from this life-threatening disease. It contains the same ingredient Ivermectin at the same dose as the Heartgard brand.
At the Holistic Veterinary Center, we recommend seasonal heartworm prevention with oral monthly products. We recommend the Heartguard tablets as this product contains no other additional dewormers. If a dog has an allergy to this product, another form can be compounded by a compounding pharmacy.
An injectable drug, melarsomine (Immiticide®), is given to kill adult heartworms. Melarsomine kills adult heartworms in the heart and adjacent vessels. This drug is administered in a series of injections. Your veterinarian will determine the specific injection schedule according to your dog's condition.