While Thanos ranks far from the top 10 villains in the Marvel Universe, The Mad Titan is powerful enough to effortlessly put down Deadpool. Given the latter ever fights Thanos with Infinity Gauntlet and all the Infinity Stones, The Mad Titan can easily erase Wade from existence, ending the fight in an instant.
While Deadpool is virtually unkillable due to his healing factor, he is not invincible. In fact, he's been beaten, maimed, and dismembered countless times in the comics and movies. Deadpool's immortality only extends to his ability to regenerate from almost any injury.
As fearsome as both opponents are, Wolverine will inevitably defeat Deadpool for a second time in Deadpool 3. The aged mutant managed to take Deadpool down in their first encounter, despite the mutant possessing a litany of extra abilities added by the Weapon X project, including laser beams that shot from his eyes.
The Avengers
Deadpool proved to be the team's most difficult opponent, because he destroyed them all in one of the most popular non-canon comics from Marvel. Not a single member of the Avengers survived the onslaught.
Cows, Clowns and Other Phobias
The fast-talking gunman seems almost fearless on the battlefield, but in reality, there's a lot that scares the Merc with the Mouth. There are two things though, that scare him above all: cows and clowns are a Deadpool weakness.
Deadpool has bovinophobia, which is the fear of cows. According to him, cows "scare the *#$% outta" him, as he believes their stare to be chilling, like they're "waiting."
A mercenary for hire, he played an important role in the series Deadpool; T-Ray served to remind Wade Wilson, also known as Deadpool, what a failure he was. He is Deadpool's archenemy for many issues and almost everything that happened to Deadpool was a part of an elaborate plan orchestrated by T-Ray.
"Spider-Man would beat Deadpool. Easily. Because Deadpool loves Spider-Man, and therefore could never bring himself truly to hurt Spider-Man. Spider-Man would take Deadpool down, but still visit him both in the hospital and later in prison.
Deadpool Killed Thor In The Most Genius Way (With His Own Hammer) - IMDb. As Deadpool killed the Marvel Universe, his murder of Thor with the God of Thunder's own hammer remains one of the Merc with a Mouth's most brutal kills.
Thanos was murdered by Deadpool when he was forced to battle other cosmic characters by the merc's use of Puppet Master's puppets.
How old is Deadpool in the comics? As Deadpool doesn't really physically age, it is speculated he must be in his late 20s, early 30s, and sometimes even 35.
Black Panther proved he was smart enough to defeat Deadpool's superhuman healing. Deadpool responds by proving that if he were ALSO to put on one of the hi-tech, vibranium-powered Black Panther suits made by T'Challa's sister Shuri, the king wouldn't be able to talk so big a game.
Few individuals in the Marvel Universe have the ability to take on all of the X-Men, but when Deadpool went on a murderous rampage he didn't just take them out, he absolutely slaughtered them.
Unlike Wolverine, whose wounds sometimes cause excruciating pain as they heal depending on the severity, Deadpool has some degree of pain insensitivity.
One of the more surprising characters to lift Mjolnir was Deadpool. How was Deadpool ever worthy of Thor's hammer? That's because he wasn't. The hammer that Deadpool lifted was actually a fake one, forged by the trickster, Loki.
Deadpool's immortality lies in his cancer and regeneration ability. According to the comics, cancer triggered his healing powers. As a result, the cancerous cells regenerate just like the normal, healthy ones do.
So long as the Spirit of Vengeance resides inside them, their human host has the potential to physically live forever. As an added bonus, they remain ageless. In Ghost Riders: Heavens on Fire #6, Johnny Blaze states that since God created the Ghost Riders, only God can destroy them.
Tony Stark was among the many heroes killed by Deadpool. He was killed among with the Avengers and New Avengers using Pym Particles to secretly shrunk a bunch of bombs and then exploding them in Avengers Mansion.
Superhuman Strength: Deadpool is rated as having a low degree of superhuman strength allowing him to lift 800 pounds. Peak Human Speed: Deadpool can run as fast as a trained athlete.
Deadpool wouldn't be able to touch flash and flash wouldn't be able to kill deadpool. It's a never ending fight, if there was any fighting at all.
A god among men, Superman has been a sworn protector of Earth, defeating the likes of Darkseid, Doomsday, Lex Luthor, and Zod to save mankind. His super strength and invulnerability would be enough to defeat Deadpool, but throw in the ability to freeze his enemies and use heat vision, it's not even close.
Thor. The Avengers deaths were pretty bad, but it was a sudden kill that didn't match up with the rest of the kills in the series. Deadpool used Pym Particles to get a bunch of explosives in and then blew them all up, killing Captain America, Spider-Woman, Iron Man, and more.
Weasel (Jack Hammer) is a fictional character appearing in American comic books published by Marvel Comics. Weasel is a friend, sidekick, information broker and arms dealer for Deadpool. Weasel is perhaps Deadpool's best friend.
No hero is more closely associated with Deadpool than Cable is. The time-traveling soldier has gone on a countless number of adventures with the wise-cracking assassin. He is, for sure, Deadpools best friend -- at least within the superhero community.
Domino. One of the most consistent members of the various incarnations of X-Force, Domino is one of the Deadpool allies we see the most throughout his movies.