Some animal studies have found that magnesium threonate is more effective at increasing magnesium ions in the brain and improving cognitive function than magnesium sulfate. Therefore, doctors may recommend magnesium L-threonate to normalize an individual's magnesium levels and for potential benefits to the brain.
But not just any magnesium supplement will do—magnesium L-threonate is the form used in studies because it has the ability to cross the blood-brain barrier to effectively increase magnesium levels in the brain.
He recommends magnesium glycinate, which is bound to the amino acid glycine and is available in capsule or tablet form. Research has found that magnesium glycinate is one of the most absorbable forms, along with citrate, chloride, lactate, and aspartate5 .
Magnesium salts, such as magnesium sulphate (MgSO4) or magnesium chloride were shown to penetrate the BBB and cause enhancement of brain intracellular free Mg2+ concentration following TBI (Heath and Vink, 1999).
According to the studies, magnesium glycinate is very suitable for those who experiencing digestive disorders such as diarrhea or have undergone bowel resection surgery, as it absorbs well in different parts of the bowel.
The answer depends on your individual needs and preferences. If you're looking to address constipation, magnesium citrate might be your best choice. If you're seeking relaxation and improved sleep, magnesium glycinate may be the better option.
The scientific evidence is mixed when it comes to using magnesium during brain injury recovery. Some studies show mild benefits in early TBI treatments, but most do not display any positive effects. However, there is also no evidence that magnesium is harmful, if you are not taking certain medications.
In addition, there is some evidence magnesium can potentially benefit mental health by acting as a mood booster, muscle relaxer, stress reducer, and sleep aid.
Magnesium glycinate offers amazing effects on sleep but does not cross the blood-brain barrier as well as magnesium threonate. Therefore, magnesium threonate offers more cognitive benefits than magnesium glycinate.
Magnesium diglycinate (Meta Mag®)
It's an easily absorbed form of magnesium that's readily transported to the bloodstream. Evidence suggests that magnesium diglycinate has superior absorption when compared to other forms including magnesium oxide and magnesium citrate.
Diseases causing malabsorption such as celiac disease and inflammatory bowel disease. Gastric bypass surgery. Hereditary syndromes causing poor absorption of magnesium (primary intestinal hypomagnesemia). Medications which can cause interference with magnesium absorption (proton pump inhibitors such as omeprazole).
Carolyn Dean, the following common factors can deplete the body's magnesium and/or increase the demand for magnesium: Supplements and drugs containing caffeine. Diuretics. Certain medications, including proton pump inhibitors, asthma medications, birth control pills, insulin, digitalis, and certain antibiotics.
Magnesium glycinate is considered to be the most effective type of magnesium for bettering sleep, as it may help relax both the nervous system and your muscles.
They also found that consuming over 550 mg of magnesium daily is linked to a roughly one-year younger brain age by 55 years old than consuming 350 mg per day, which is close to the average daily intake.
While a healthy kidney is capable of excreting excess magnesium, a damaged kidney may not have this same advantage. Thus, individuals with heart or kidney problems (e.g., chronic kidney disease) should especially get approval from their provider before using the supplement.
High doses of magnesium from supplements or medications can cause nausea, abdominal cramping and diarrhea. In addition, the magnesium in supplements can interact with some types of antibiotics and other medicines.
Taking large or frequent doses of dietary magnesium supplements, including magnesium glycinate, can cause adverse effects, including diarrhea, nausea, and stomach cramps. Extremely high intakes of magnesium can lead to an irregular heartbeat and potentially a cardiac arrest, which can be dangerous.
Mg mitigates the production of ROS in various tissues, including the CNS. In the brain of different experimental models, Mg has been shown to contrast oxidative damage after hypoxia [42], counter maternal inflammation-induced oxidative stress [37], and protect against carbon monoxide-induced brain damage [43].
“Our study shows a 41 percent increase in magnesium intake could lead to less age-related brain shrinkage, which is associated with better cognitive function and lower risk or delayed onset of dementia in later life,” lead author and Ph.
To treat the effects of malabsorption, you may need supplemental nutrition, either in an oral formula, by tube or through a vein. You may need specific digestive enzymes replaced, either to treat a food intolerance or general pancreatic insufficiency.
Low levels of carotene in the blood suggest deficient absorption of fat-soluble vitamins or dietary deficiency. Serum carotene levels are generally low in people with fat malabsorption. Vitamin B12 and folate levels may also be used to screen for malabsorption.