If vitamin B12 deficiency is left untreated, it can cause lasting serious side effects that affect the nervous system and brain. More severe side effects of vitamin B12 deficiency include: Peripheral neuropathy. Degeneration of the spinal cord.
The consequences and severity of B12 deficiency are variable depending on the degree of deficiency and its duration. Major organ systems affected include the blood, bone marrow and nervous system. Megaloblastic anemia results from a defect in thymidine and therefore DNA synthesis in rapidly dividing cells.
Vitamin B12 is required for the development, myelination, and function of the central nervous system; healthy red blood cell formation; and DNA synthesis [1,4,5]. Vitamin B12 functions as a cofactor for two enzymes, methionine synthase and L-methylmalonyl-CoA mutase [1-3,5].
The excess B12 is stored in the liver to be used when your body needs it or flushed out by the kidneys. Hence, an overdose is unlikely to happen. Having said that, we insist that you keep checking your B12 levels from time to time and consult your doctor for appropriate guidance.
Key points about vitamin B12 deficiency anemia
Without enough red blood cells, your tissues and organs don't get enough oxygen. Without enough oxygen, your body can't work as well.
Vitamin B12 deficiency can also cause symptoms that affect your brain and nervous system (neurological symptoms), including: numbness. muscle weakness. psychological problems, which can range from mild depression or anxiety, to confusion and dementia.
On one hand, a lack of vitamin B12 blocks the synthesis of S-adenosylmethionine (SAM), which results in the production of methionine synthase. However, SAM is the main cellular antioxidant in the liver, and a lack of SAM may cause liver damage and differentiation.
An increased serum content of vitamin B12 found in acute and chronic liver diseases has been attributed to the release of the vitamin from the liver owing to hepatic necrosis and/or to an increased capacity of the serum to bind vitamin B12 as a result of abnormalities in the serum proteins.
Vitamin B12 binds to the protein in the foods we eat. In the stomach, hydrochloric acid and enzymes unbind vitamin B12 into its free form. From there, vitamin B12 combines with a protein called intrinsic factor so that it can be absorbed further down in the small intestine.
Vitamin B12 is an essential nutrient that helps the body create DNA, nourishes the brain and nervous system, and assists with the formation of healthy red blood cells. The nutrient occurs naturally in meat, fish, and dairy products, and can be created in a laboratory.
How to raise your B12 levels fast. The most common way to treat B12 deficiencies is by adjusting your diet. If this is unsuccessful, vitamin supplements may be recommended. If you're looking to boost the amount of vitamin B12 in your diet, you should eat more animal products, like meat, seafood, dairy and eggs.
Inadequate dietary intake
A balanced diet typically provides sufficient vitamin B12; however, strict vegans and people with a poor diet are at higher risk of developing a deficiency. Good sources of vitamin B12 include: Meat. Fish.
Symptoms of Vitamin B12 Deficiency
A mild deficiency may cause no symptoms. But if untreated, it may lead to symptoms such as: Weakness, tiredness, or lightheadedness. Heart palpitations and shortness of breath.
People with vitamin B12 deficiency can have neurological symptoms and/or damage without anemia (lack of red blood cells). General physical symptoms of vitamin B12 deficiency can include: Feeling very tired or weak. Experiencing nausea, vomiting or diarrhea.
Stage 1 is decreased levels of vitamin B12 in the blood. Stage 2 is low concentration of vitamin B12 in the cell and metabolic abnormalities. Stage 3 is increased levels of homocysteine and MMA and decreased DNA synthesis resulting in neuropsychiatric symptoms. Stage 4 is macrocytic anemia.
Older people are more likely to get vitamin B12 deficiencies because it is absorbed from food by stomach acid. As you age, however, your stomach acid starts to decline. That's why it is important to get tested for a vitamin B12 deficiency as you age.
Vitamin B12 is stored in excess in the liver, decreasing the likelihood of deficiency. However, in cases in which vitamin B12 cannot be absorbed, for example, due to dietary insufficiency, malabsorption, or lack of intrinsic factor, hepatic stores are depleted, and deficiency ensues.
Nonalcoholic steatohepatitis (NASH) is an aggressive form of fatty liver disease that can cause severe liver damage and greatly impact overall health.
A high-dose B complex supplement (with 1,000 mcg of B-12) hurt, rather than helped, people with type 1 or type 2 diabetes and advanced kidney disease, resulting in a worsening of kidney function and an increase in the risk of heart attack, stroke and death.
The findings from this research suggest that vitamin B12 and folic acid may have the potential to positively impact liver health, specifically when it comes to individuals with fatty liver disease. These particular nutrients, in the form of supplements, may even hold the possibility of reversing fatty liver disease.
Although it's uncommon, vitamin B12 or folate deficiency (with or without anaemia) can lead to complications, particularly if you have been deficient in vitamin B12 or folate for some time. Potential complications can include: problems with the nervous system. temporary infertility.
There are certain foods that also need a cut-down in case of vitamin B12 deficiency. “Some foods and drinks can interfere with vitamin B complex intake like alcohol, caffeine and processed foods, etc should be avoided completely,” Shah added.
Several commercially available test kits allow you to collect a sample for vitamin B12 testing at home. Some kits test only your vitamin B12 level. Others test B12 in combination with other vitamins, and there are at-home micronutrient test kits that include B12 in the panel.
Bananas are a cheap, healthy, and nutrient-dense fruit that can easily become a part of every individual's diet. It is one of the best fruits rich in vitamin B12.