Due to the satirical nature of One Punch Man, it's safe to assume that Saitama is intended to represent the strongest anime character of all time and it's somewhat difficult to dispute that assertion.
Satoru Gojo's (Jujutsu Kaisen) cursed technique - Limitless allows him to bring the concept of "Infinity" into reality, and his Domain Expansion, Infinite Void, allows him to inundate his opponent with an infinite stream of information, leaving their mind and body in a catatonic state.
At the end of the day, of all the great superpowers, none are as great as power mimicry. Unlike shapeshifting, which merely allows a person to copy the looks of another, power mimicry allows the person to copy whatever it is the other can do. It's basically the power to end all powers.
The God of Strength is a major antagonist in the anime/manga series Kinnikuman. He is one of the Five Evil Gods who act as the main antagonist force in the Survivor Match for the Kinniku Throne Arc.
The fight would ultimately come down to who can last the longest, and Saitama is physically unmatched in every regard. A single punch would floor Goku, but the Zenkai Boost may not be enough to help.
The longest-running anime TV series is Fuji TV's Sazae-san (Japan), which was first broadcast on 5 October 1969 and has run for 53 years 58 days, as of 2 December 2022. Produced by the studio Eiken, the animation features Sazae and her family focusing on day-to-day life in the suburbs.
Vegeta has surpassed Goku by learning techniques his rival could not, but the Saiyan Prince hates that his new abilities are "parlor tricks." Warning: contains spoilers for Dragon Ball Super chapter 73!
The most powerful is Hyperion, and much like Superman, he would end Goku. Hyperion usually hails from another universe and is frequently the most powerful hero around. One version of Hyperion beat every hero and villain on Earth, and another flew through Galactus's head, killing him.
While Dragon Ball's Goku has unlocked god-like powers of his own, he still doesn't stand a chance against Lord Beerus, the God of Destruction if the two were to ever fight again. There is, however, one classic Dragon Ball hero who actually could fend off Beerus with one ingenious attack.