It is easy to see that Sasuke supplants Madara in every category except for chakra reserves as the latter was the jinchuriki of the Ten-Tails. However, Sasuke is far ahead in all the other categories. Consequently, Sasuke is undoubtedly the strongest Uchiha in Naruto.
Can adult Sasuke alone defeat 3-eyed Madara? No, he could not. Juubidara + Rinnesharingan was simply too broken. So broken that he needed to be killed off by an overpowered goddess that barely knew how to fight.
Sasuke Uchiha is the strongest known Uchiha in the Naruto series. He mastered the Sharingan at quite a young age and, following Itachi's death, gained the Mangekyo Sharingan. After implanting his brother's eyes, Sasuke became the only second person after Madara to have the Eternal Mangekyo Sharingan.
Black Zetsu was central to one of the biggest shocks in Naruto during the 4th Great Ninja War. It was he who stabbed Madara Uchiha in the back and struck him down when he was at the pinnacle of his powers. Zetsu was then revealed to be the perpetrator of the plan to bring Kaguya back.
While Sasuke did master the power of Rinnegan for over a decade, Madara was always a far greater Shinobi in terms of using his Jutsus. Hence, Sasuke in his prime will have no chance of soloing Madara in his prime.
1 CAN'T BEAT: Madara Uchiha
Unfortunately for Sakura, she doesn't have any such power. Her strength pales in comparison to Madara's, and so does everything else about her. To someone like Madara, Sakura is barely a threat, and in case they ever come face-to-face, Madara won't have to stress too much to defeat her.
Sasuke was stated to be the strongest Uchiha to ever have been born, including Madara. So, obviously, his powers do exceed Madara's. With his Choku-tomou Rinnegan and Indra's arrow, he is almost invincible. As a result, he is also one of the Naruto characters who can defeat Madara.
One of the strongest shinobi to have ever existed, Naruto Uzumaki is one of the few characters in the entire series who can defeat Madara Uchiha. During the 4th Great Ninja War, the two clashed for a long time and Naruto was, more or less, able to keep up with him without any significant problems.
Madara Uchiha is among the most powerful shinobi to have ever lived, and his power only increased when he attained the power of the Sage of the Six Paths. He was able to fend off both Naruto Uzumaki and Sasuke Uchiha for a time in this form, and Kakashi Hatake would likely be unable to subdue Madara on his own.
Black Zetsu was one of the members of the Akatsuki and was said to have been the will incarnate of Madara Uchiha. He did everything he could to make Madara's dreams come true, only to betray him at the very last minute.
Who is the god of Uchiha? Indra Otsutsuki is revealed to be the creator/ founder of the renowned Uchiha Clan in Naruto. He was the eldest son of Hagoromo Otsutsuki (The Sage of Six Paths) and the elder brother of Ashura Otsutsuki.
Madara Uchiha is a legendary ninja with immense skill and chakra, and during the 4th Great Ninja War, he proved to be stronger than Sasuke. He possesses far more battle experience, and his Fire-Style ninjutsu was powerful enough to bathe an entire battlefield in fire.
The Rinne-Sharingan has nearly all the powers of the Rinnegan, along with the ability to cast powerful Genjutsu known as Infinite Tsukuyomi. Furthermore, this eye can also use some very interesting space-time ninjutsu abilities that, if used properly, prove to be deadly.
1) Sasuke Uchiha
Sasuke's eyes (which are still Sasuke's eyes even after Itachi's are transplanted) are without a doubt the most powerful in the series. While both of his Mangekyo cast Amaterasu, he can also manipulate the size and shape of his black flames, something Itachi couldn't do.
3) Madara Uchiha
At the height of his power, he was able to slaughter entire groups of ninja, take on the Kage, and slice the tops of mountains off! Alone, Boruto wouldn't stand much of a chance.
Although the two have never fought, the fact that Tsunade struggled against Madara Uchiha and Sasuke demolished a stronger version of him is enough to point out that he's much stronger.
Hagoromo and Hamura battle the Ten-Tails. In the final confrontation between the Ten-Tails and Kaguya's sons, Hagoromo and Hamura, the two managed to seal the beast into what would become the moon; its chakra was sealed separately within Hagoromo and making him the first jinchūriki.
Prime Madara may be as strong as Pain, which means that Jiraiya's Sage Mode can handle him. This mode enhances all of Jiraiya's abilities, and thanks to the toad sages that aid him in battle, he can trap Madara in a genjutsu that even Pain could not break free from.
In conclusion, Obito Uchiha would defeat Itachi Uchiha when comparing the two characters in their strongest forms. Obito has one of the strongest, if not the strongest, Sage Mode in the series and has enough chakra reserve to beat Itachi.
Just like Naruto, Sasuke has grown dramatically over the years and can now be considered the strongest there is. His skill with the Rinnegan is impeccable, as is everything else about him. There's no doubt that he's far stronger than Pain.
Madara was much stronger than Obito to begin with, and the fact that his version of the Ten-tails was perfect made him even stronger. When compared to Madara, Obito stands absolutely no chance.
Sasuke aside, Madara is easily the strongest Uchiha in the land. His boldness knows no limits after we witnessed him directly challenge the God of the Shinobi in order to compare himself directly to the best. After obtaining the power of Rinnegan, he went on to control the Ten-Tailed beast's Jinchuriki.