Ibuprofen is generally well-tolerated by the kidneys, but you should only take it as prescribed for a few days. The drug increases your risk of kidney impairment, especially among older adults with chronic kidney disease. This side effect usually presents within the first month of consistent NSAID use.
Acute kidney injury can happen with any NSAID, including ibuprofen. The risk for kidney damage is higher for adults over 60 and people who have chronic kidney disease (CKD). This serious side effect is seen most often within the first month of starting a regular NSAID regimen.
However, taking doses that are too large (usually more than six or eight tablets a day) may temporarily- and possibly permanently- reduce kidney function.
Time to Onset of Ibuprofen- and APAP-Associated Renal Injury
The average onset time of APAP-related kidney injury was 32.74 days, which was about a quarter of that of ibuprofen-related kidney injury (115.82 days).
Don't take more than 1,200 mg of ibuprofen in one day. For OTC ibuprofen, this equates to a maximum of 6 pills per day. Additionally, avoid taking ibuprofen for longer than 10 days, unless directed to do so by your doctor.
Is kidney damage caused by NSAIDs reversible? The damage that is caused by these medications can be reversible if the drug is stopped, but there is also a chance that the damage will not be able to be reversed. In some cases, the damage is so severe that it will cause the patient to need dialysis.
Over-the-counter Tylenol (generic acetaminophen) is often the best choice for people with high blood pressure, heart failure, or kidney problems.
Nonprescription pain relievers such as acetaminophen (Tylenol, others), aspirin, ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others) can damage your liver, especially if taken frequently or combined with alcohol.
Acetaminophen is generally considered safer than other nonopioid pain relievers because it doesn't cause side effects such as stomach pain and bleeding.
Study: Ibuprofen Found Safest NSAID for the Kidney.
Ibuprofen constricts blood vessels to reduce pain and inflammation, but this also decreases renal blood flow. This reduction in blood flow can reduce your kidney function, and improper use of medication such as ibuprofen may impair the kidneys.
Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin.
adults – can usually take 1 or 2 tablets (200mg) every 4 to 6 hours, but shouldn't take more than 1,200mg (6 x 200mg) tablets in the space of 24 hours.
Medications like ibuprofen can irritate your stomach lining and cause problems ranging from mild nausea to ulcers. There are also reports that some NSAIDs may increase your risk of developing heart disease. So while occasional use is fine, continued daily use should only be done under your doctor's supervision.
Hepatotoxicity. Rates of serum aminotransferase elevations during low dose, chronic ibuprofen therapy are comparable to those that occur with placebo controls (0.4%). However, higher rates of ALT elevations occur with high, full doses of 2,400 to 3,200 mg daily (up to 16%).
A gel form of the prescription NSAID diclofenac (Voltaren Gel) is one option. Only a very small amount of the drug gets into the bloodstream, so it may be safe for your kidneys. However, topicals may not work well for hip pain, because the joint is too deep for the medication to penetrate.
Generally, the renal failure with NSAIDs is acute and reversible, though analgesic nephropathy with papillary necrosis and chronic renal failure are reported.
Naproxen. Another anti-inflammatory drug, which works much like ibuprofen. Some studies show this may be a better choice than ibuprofen for people at risk for heart disease.
If you have trouble sleeping with pain, do not take this medication for more than five nights in a row. Talk to your doctor about other treatment options suitable for you if you have sleeplessness as a result of ongoing pain.
by Drugs.com
Adults can take one or two ibuprofen 200mg tablets (200mg to 400mg) three or four times daily if they need to. You should only take ibuprofen every 4 to 6 hours. You should not take more than 6 tablets (1200mg) in total in one day if you have brought them over the counter, from a supermarket or drug store.
Taking ibuprofen daily, with doses spaced out six to eight hours, for more than five to seven days is not recommended or viewed as safe by medical professionals, says Janet Morgan, M.D., an internist at the Cleveland Clinic. In this case, taking more than 600mg total each day is not recommended, either, says Dr.
Don't take for more than 10 days and consult your doctor if pain continues. Avoid painkillers that include mixed analgesics such as ibuprofen, caffeine, and acetaminophen. The mixed painkillers are more likely to cause side-effects for kidney patients. Don't take painkillers with alcohol.
Unlike Ibuprofen and other NSAIDs, the active ingredient in Tylenol (acetaminophen) does not cause damage to the kidneys. In fact, the National Kidney Foundation recommends acetaminophen as the pain reliever of choice for occasional use in patients who have underlying kidney disease.
Ibuprofen, on the other hand, is removed from your body by your kidneys. Taking it for a long time can cause kidney damage and stomach bleeding. Using high doses of ibuprofen for longer than recommended can increase your risk of: blood clots.