Calcifications or “corpora arenacea” are often found in the pineal gland, with a globular or concentric lamellar shape [6]. The incidence of these calcifications is increased over the age of 30 [7].
Morphological changes associated with pineal calcification include changes in the production of melatonin, due to the decreased function in the pineal gland parenchyma, and results in decreased pineal volume, reduced melatonin production in humans [14], and altered sleep patterns [59].
Your pineal gland tends to calcify as you age. While some calcification is normal, excessive calcification can prevent your pineal gland from functioning properly. Some studies have revealed that the degree of calcification of the pineal gland is higher in those affected by Alzheimer's disease.
The prevalence of pineal gland calcification in this study was 61.65% [95% CI: 52.81, 70.49], with a heterogeneity of I2 = 97.7%, P ≤ 0.001, but different studies reported variation in the prevalence of pineal gland calcification from 35.2 to 76% [22, 25].
The development of the mature gland is seen in the first decade of life. Basically, the pineal gland will increase in size from birth to about 2 years in age.
Our findings indicate that stress may impair pineal sympathetic inputs, leading to an abnormal melatonin release that may contribute to environmental maladaptation. In addition, we propose that the pineal gland is a target of glucocorticoid damage during stress.
Light exposure is the most important factor related to pineal gland function and melatonin secretion. A single daily light pulse of suitable intensity and duration in otherwise constant darkness is enough to phase shift and to synchronize the melatonin rhythm to 24h (16).
Fluoride is a fundamental ingredient in toothpaste that helps prevent cavities in the teeth. In some countries, it is also added to drinking water. Higher levels of fluoride in the human pineal gland have been positively correlated with pineal calcification. However, correlation does not mean causation.
An intact and functional pineal gland is necessary for preserving optimal human health. Unfortunately, this gland has the highest calcification rate among all organs and tissues of the human body. Pineal calcification jeopardizes melatonin's synthetic capacity and is associated with a variety of neuronal diseases.
The pineal gland is not the only part of the body that can become calcified. The crystals can also form in the joints, heart valves, and breast tissue. Sometimes, calcification impairs the functioning of the affected organ. In the case of pineal calcifications, the gland can become unable to produce melatonin.
The pineal gland was once dubbed the “third eye,” which originated for many reasons, ranging from its location deep in the center of the brain to its connection to light.
A deficient production of melatonin can result in anxiety and mood disorders, lowered basal body temperature, insomnia, elevated estrogen/progesterone ratio, and immune suppression associated with cancer.
Your pineal gland is part of your endocrine system. The full impact of melatonin in humans isn't totally clear, but most research shows it helps to synchronize circadian rhythms in different parts of your body. Circadian rhythms are physical, mental and behavioral changes that follow a 24-hour cycle.
Therefore, it is possible that excess fluoride exposure may contribute to increased pineal gland calcification and subsequent decreases in nighttime melatonin production that contribute to sleep disturbances.
From its unique perch between the brain's two hemispheres, the endocrine system's pineal gland secretes melatonin, a derivative of serotonin, which generally contributes to feelings of well-being and happiness.
Local control - serotonin formation
The pineal gland receives adrenergic innervation, which activates a cascade of circadian events that leads to the nightly formation of melatonin from serotonin.
The melatonin secretion by the pineal gland is generally regarded as particularly sensitive to electric, magnetic, and electromagnetic field influences.
What is the pineal gland? The pineal gland is a very small gland in the centre of the brain shaped like a pine cone, which is where it gets its name. It is part of the endocrine system. It produces a hormone called melatonin.
The third eye is a chakra located in the middle of the forehead between the eyebrows. It's associated with intuition, insight, and mysticism. The third eye is the sixth out of seven chakras that control the meridian of the body, mind, and spirit. It can take us to a place of higher consciousness and enlightenment.
The pineal gland, conarium, or epiphysis cerebri, is a small endocrine gland in the brain of most vertebrates. The pineal gland produces melatonin, a serotonin-derived hormone which modulates sleep patterns in both circadian and seasonal cycles.