High doses of vitamin D can raise blood levels of calcium (hypercalcemia), which can damage the heart, kidneys, and blood vessels.
The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.
Vitamin D is another supplement that can cause heart palpitations when taken in large amounts. Indeed, a March 2018 review found that excess vitamin D in your system was linked to an increased risk of atrial fibrillation, a condition that causes an irregular and often rapid heartbeat.
Excess Vitamin D harms the heart - Study
Scientists have long known that low levels of the nutrient can hurt the heart, but new research shows that higher than normal levels can make it beat too fast and out of rhythm, a condition called atrial fibrillation.
Use vitamin D cautiously if you're taking drugs processed by these enzymes. Digoxin (Lanoxin). Avoid taking high doses of vitamin D with this heart medication. High doses of vitamin D can cause hypercalcemia, which increases the risk of fatal heart problems with digoxin.
Vitamin D exerts pleiotropic antiatherogenic effects, such as regulation of vascular cell growth, migration and differentiation, immune response modulation, and regulation of cytokine production, inflammation, and fibrotic pathways, all of which play a critical role in atherosclerotic plaque formation and rupture (37).
vitamin D is an emerging risk factor of AF, and is implicated in the pathophysiology of atrial fibrillation. It has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system.
It has long been known from case series that vitamin D excess can lead to atherosclerosis and vascular calcification in humans. In the 1980s, ecological studies provided data that deficient human vitamin D status may also increase the risk of developing cardiovascular disease (CVD).
The idea that higher vitamin D intake could improve heart health emerged years ago when observational studies found people with higher blood levels of vitamin D had lower rates of cardiovascular disease.
Yes, getting too much vitamin D can be harmful. Very high levels of vitamin D in your blood (greater than 375 nmol/L or 150 ng/mL) can cause nausea, vomiting, muscle weakness, confusion, pain, loss of appetite, dehydration, excessive urination and thirst, and kidney stones.
Don't take very high doses of vitamin D, as if you do this over a long period of time, it can cause too much calcium to build up in the body, which can weaken the bones and damage the kidneys and heart.
But how do you flush vitamin D out of your system – and can you even do that? Yes, by ensuring you consume plenty of water. This will encourage urination, allowing your body to shed the excess vitamin D and calcium more quickly. Prescription diuretics like furosemide can also be helpful.
There is no simple answer as to the amount of time it takes vitamin D to leave the body. However, with the knowledge that calcidiol provides the best indication of vitamin D levels, it can be asserted that in a time period of 15 days, your body will deplete half of its supply of serum vitamin D.
Conclusion: Oral vitamin D 3 has no significant effect on blood pressure in people with vitamin D deficiency. It reduces systolic blood pressure in people with vitamin D deficiency that was older than 50 years old or obese.
Some researchers have suggested that vitamin D deficiency (VDD) could be associated with such symptoms as chest pain, anxiety, and fatigue (Ahmed, 2016; Roy et al., 2014; Sagarad et al., 2016).
One of the adverse side effects associated with taking nutritional supplements is arrhythmia. Arrhythmia is a disruption to the heart's electrical signals or a short circuit occurring in one of the heart's chambers leading to a reduction in circulation to the body's organs. This can result in heart failure or stroke.
Optimal Vitamin K2 intake is crucial to avoid the calcium plaque buildup of atherosclerosis, thus keeping the risk and rate of calcification as low as possible.
Taking too much vitamin D is not good either, as it can lead to hypercalcemia, or high calcium levels, which can also cause irregular heartbeat. Atrial fibrillation (A-fib), one of the most common forms of irregular heartbeat, is a condition in which the heart's upper chambers quiver instead of pump rhythmically.
Vitamin D conspires with immune cells called macrophages either to keep arteries clear or to clog them. The macrophages begin their existence as white blood cells called monocytes that circulate in the bloodstream.
Vitamin D and sleep: The surprising connection
Early research suggests it is inversely related to melatonin, your sleep hormone. Increasing vitamin D levels may suppress melatonin levels. So, it makes sense that taking it at night could disrupt your sleep.
Very high levels of vitamin D can damage the kidneys. It also raises the level of calcium in your blood. High levels of blood calcium (hypercalcemia) can cause confusion, kidney failure, and irregular heartbeat (arrhythmia). Most cases of vitamin D toxicity happen when someone overuses vitamin D supplements.
In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe.