Your liver can keep working even if part of it is damaged or removed. But if it starts to shut down completely—a condition known as liver failure—you can survive for only a day or 2 unless you get emergency treatment. Many things can affect liver function.
Life expectancy by stage
Compensated cirrhosis: People with compensated cirrhosis do not show symptoms, while life expectancy is around 9–12 years. A person can remain asymptomatic for years, although 5–7% of those with the condition will develop symptoms every year.
Many people recover from liver failure with treatment. If a transplant is necessary, most patients go back to their daily activities within six months. People who have received a transplant need lifelong medical care, including medications to prevent their body from rejecting the new organ.
Over time, liver disease can cause cirrhosis (scarring). As more scar tissue replaces healthy liver tissue, the liver can no longer function properly. Left untreated, liver disease can lead to liver failure and liver cancer.
Most people with liver disease report abdominal pain. Pain in your liver itself can feel like a dull throbbing pain or a stabbing sensation in your right upper abdomen just under your ribs.
Healing can begin as early as a few days to weeks after you stop drinking, but if the damage is severe, healing can take several months. In some cases, “if the damage to the liver has been long-term, it may not be reversible,” warns Dr. Stein.
It takes upwards of ten years for alcohol-related liver disease to progress from fatty liver through fibrosis to cirrhosis to acute on chronic liver failure. This process is silent and symptom free and can easily be missed in primary care, usually presenting with advanced cirrhosis.
A liver blood test measures the levels of various things in your blood, like proteins, liver enzymes, and bilirubin. This can help check the health of your liver and for signs of inflammation or damage.
People with acute liver failure are often treated in the intensive care unit of a hospital in a facility that can perform a liver transplant, if necessary. Your provider may try to treat the liver damage itself, but in many cases, treatment involves controlling complications and giving your liver time to heal.
For some people, death from liver failure can be sudden and unpredictable. Liver failure most often develops over many years, but it can sometimes occur suddenly. Various factors, such as infections, bleeding, and kidney failure, can arise as complications of liver failure and lead to a faster death.
Liver failure is a serious condition that requires immediate medical attention. Your healthcare provider will probably do an evaluation to find out if you have a history of drug use, exposure to toxins, and to check for signs of hepatitis. These signs include jaundice, fatigue, and abdominal pain.
When a patient's liver disease reaches cirrhosis, a stage when the liver damage can no longer be reversed, it becomes a terminal diagnosis. Unlike most terminal illnesses, a cure may be available for some patients through a liver transplant.
Acute liver failure can develop quickly in an otherwise healthy person, and it is life-threatening. If you or someone you know suddenly develops a yellowing of the eyes or skin; tenderness in the upper abdomen; or any unusual changes in mental state, personality or behavior, seek medical attention right away.
Stage 1 is inflammation of your liver, caused by your immune system reacting to a foreign substance, like toxins. Chronic inflammation can lead to an enlarged liver. Inflammation can result from fatty liver, hepatitis, and other causes. Stage 2 is liver fibrosis or liver scarring, caused by chronic inflammation.
See a GP if:
feeling very tired and weak all the time. loss of appetite – which may lead to weight loss. loss of sex drive (libido) yellow skin and whites of the eyes (jaundice)
Long-term intake of more than 30 g of absolute alcohol per day increases the risk of alcoholic liver disease; liver disease is nearly certain in long-term consumption in excess of 80 g of absolute alcohol per day.
Alcohol is predominantly broken down in the liver through the actions of an enzyme called alcohol dehydrogenase. On average, the liver can metabolize 1 standard drink per hour for men, or about 0.015g/100mL/hour (i.e., a reduction of blood alcohol level, or BAC, by 0.015 per hour).
Avoiding Alcohol
Moderate or heavy alcohol use can cause additional damage and fat accumulation in the liver in people with NAFLD. Therefore, patients with NAFLD should avoid alcohol entirely if possible.
As liver failure progresses, you may experience some or all of the following symptoms: Jaundice, or yellow eyes and skin. Confusion or other mental difficulties. Swelling in the belly, arms or legs.
“The scary thing is that they're only in their 30s and 40s,” he says, noting that the chances of developing liver disease go up the longer a person has been drinking and is most common between the ages of 40 and 50. Other Yale Medicine doctors have diagnosed people with liver disease when they are still in their 20s.
It is estimated that alcohol-related fatty liver disease develops in 90% of people who drink more than 40g of alcohol (or four units) per day. That's roughly the equivalent of two medium (175ml) glasses of 12% ABV wine, or less than two pints of regular strength (4% ABV) beer.