You start feeling those usual hunger pangs again, and consequently, you may start eating more to satisfy that hunger. An increase in your consumption can lead to the regaining of weight that was lost. A 2022 study found that most individuals gain weight back a year after stopping the medication.
Semaglutide has become more and more popular as a weight loss aid, and many patients wonder what happens if you stop taking it. While it's possible to gain weight back after stopping Semaglutide or other GLP-1 agonists, it's not a guaranteed side effect.
Studies have shown that semaglutide injections like Ozempic are good for weight loss but experts warn once people stop taking the drugs, they regain most of the lost weight.
It's been hailed as a “miracle” weight loss drug for people living with obesity. But, as with many medications, it only works for as long as it's used. As soon as someone stops their regular course of semaglutide, their weight is likely to come right back.
A person can stay on Ozempic® so long as they are tolerating the medication and it is deemed appropriate by their treating provider. There is no specific time frame when someone should stop taking Ozempic as it is a medication that is intended for chronic (long-term) use.
The anti-diabetic medication “Ozempic” (semaglutide) made by Danish pharmaceutical company Novo Nordisk. Patients taking blockbuster obesity drugs Ozempic or Wegovy will pack the pounds back on after they stop taking the medications.
“GLP-1 medications [like Ozempic] are designed to be taken long-term,” explains Dr. McGowan. “They are chronic medications for the treatment of chronic conditions (both diabetes and obesity).”
For people who are trying to lose weight, whether or not they need to, Ozempic will flush out of your body and you'll go back to where you were, Sadhu said. There's no withdrawal and you don't need to taper off the drug, although you may feel hungry again and regain the weight.
Stopping Ozempic
Meanwhile, these are “not medications that our body becomes addicted to, there are no significant withdrawals and no significant major rebound effects,” emphasized Dr. Warriner. In her patients with diabetes, Warriner has also observed a return of increased appetite over time.
Ozempic isn't approved for weight loss. But because of how it works, some people taking Ozempic lose weight as a side effect. If you don't have diabetes, taking Ozempic for weight loss is considered an off-label use. Wegovy, a higher-dose version of Ozempic, is approved to help people manage their weight.
Activity that uses 1,500 to 2,000 calories per week is recommended for maintaining weight loss. Adults should try to get at least 40 minutes of moderate to vigorous level physical activity at least 3 to 4 times per week. Diet and exercise are vital strategies for losing and maintaining weight.
Other serious side effects of Ozempic include thyroid tumors, pancreatitis, changes in vision, hypoglycemia, gallbladder issues, kidney failure and cancer. The most severe complications Shah sees in her patients are pancreatitis and gallbladder issues — either can lead to hospitalization.
On average, a user can lose about 3 to 5% of their body weight after using Ozempic for a month regularly. This equates to about 4 to 6 pounds on average. Using a higher potency of the drug may result in more weight loss, but it isn't recommended that you start taking it right away.
(No member of the Kardashian family has publically said they use Ozempic.) Ozempic is the brand name for the medication semaglutide, which treats diabetes by balancing out hormones like insulin.
We know that Ozempic works to help your body regulate its food, sugar and fat metabolism, but there are other health benefits that were also discovered during the drug trials.
Another study, published in August 2022, found that one year after participants stopped taking semaglutide, they regained two-thirds of the weight they had lost. Weight gain can start to happen pretty immediately after you stop injecting Ozempic, or the other similar medications.
Store your pen in use for 56 days at room temperature between 59ºF to 86ºF (15ºC to 30ºC) or in a refrigerator between 36°F to 46°F (2°C to 8°C). The Ozempic® pen you are using should be disposed of (thrown away) after 56 days, even if it still has Ozempic® left in it. Write the disposal date on your calendar.
Dr. Louis Aronne, director of the Comprehensive Weight Control Center at Weill Cornell Medicine, told "GMA" that rebound weight gain can be common after stopping semaglutide because the drug is no longer working in the body.
The active ingredient in Ozempic is semaglutide, which works by inducing satiety. This feeling of being satisfied or “full”, suppresses appetite. This is why it works for weight loss. Semaglutide also helps the pancreas produce insulin, which is how it helps manage type 2 diabetes.
Still, Ozempic and other GLP-1 medications will be most effective for weight loss and blood sugar control when combined with a healthy diet and regular exercise. Generally, eating healthy foods and avoiding foods high in sugar, calories, and unhealthy fats while taking Ozempic helps.
Ozempic helps reduce cravings and suppress appetite, which helps you consume fewer calories. Each person has a different starting weight, metabolic weight and possibly even different underlying health conditions.