Results showed that patients lost on average up to 14 lb (6.4 kg), although some people also gained weight. Study 1: Patients using Ozempic 0.5 mg dose lost on average 8 lb (3.6 kg), those using 1 mg dose lost 10 lb (4.5 kg), and those taking placebo (an inactive treatment) lost 3 lb (1.4 kg).
Ozempic® is not a weight-loss drug. In 2 different studies looking at A1C, adults with type 2 diabetes lost on average: Ozempic®: 8 lb (0.5 mg) and 10 lb (1 mg) vs placebo: 3 lb. Ozempic®: 12 lb (1 mg) and 14 lb (2 mg)
Still, Ozempic and other GLP-1 medications will be most effective for weight loss and blood sugar control when combined with a healthy diet and regular exercise. Generally, eating healthy foods and avoiding foods high in sugar, calories, and unhealthy fats while taking Ozempic helps.
Getting started
The beginning dose is 0.25 mg once a week for the first 4 weeks. This will help give your body a chance to get used to the medicine. At Week 5, your health care provider will increase the dose to 0.5 mg once a week.
You may need a higher dosage of Ozempic
The same holds true for Ozempic's weight loss results. People taking higher doses of Ozempic tend to lose more weight. In the landmark study we cited above, people lost 7% of their body weight, on average, within a year and a half of taking 1mg of semaglutide.
Once you begin using Ozempic, some people can find it takes several weeks to see any weight loss, yet others may see some weight loss within a week or 2. While it can be difficult, try to remain patient — change looks different for everyone.
Ozempic comes as a pre-filled pen injector. It is injected under the skin (subcutaneously) once weekly. The starting dose is 0.25 mg per week, and this can be increased to 0.5 mg after 4 weeks based on blood sugar response and tolerance. The maximum approved dose of Ozempic is 1 mg weekly.
The active ingredient in Ozempic is semaglutide, which works by inducing satiety. This feeling of being satisfied or “full”, suppresses appetite. This is why it works for weight loss. Semaglutide also helps the pancreas produce insulin, which is how it helps manage type 2 diabetes.
It is important to have your blood sugar levels checked regularly. This is the only way to know if Ozempic is working properly for you. Your doctor will recommend how frequently you should do this. Store unused Ozempic pens in the fridge at 36°F to 46°F (2°C to 8°C).
So, on average, with the recommended starting Ozempic dose of 0.25 mg, a 500 to 1000 calorie reduced diet, and exercise 3 times a week, you can expect to lose 3-5 pounds in the first month of treatment, which works out to about 3% of body weight for most overweight or obese individuals.
Ozempic is a long-term medication used to control blood sugar in people with type 2 diabetes. It is a once-weekly injection using a prefilled Ozempic pen. If you take too much Ozempic, you could develop severe hypoglycemia (low blood sugar).
On average, a user can lose about 3 to 5% of their body weight after using Ozempic for a month regularly. This equates to about 4 to 6 pounds on average. Using a higher potency of the drug may result in more weight loss, but it isn't recommended that you start taking it right away.
Ozempic is also used off-label for weight loss. In particular, it can help reduce the amount of belly fat. This is because Ozempic works by making you feel fuller for longer, which can help you resist overeating by controlling cravings and hunger.
A study found that at the highest dose of Wegovy (2.4 mg), patients lost on average 15% of their total body weight after 1 year. In patients with diabetes, one study showed that taking Ozempic at the highest dose of 2 mg led to on average ~15 lbs (6.9 kg) weight loss after 40 weeks.
It can boost your metabolism, lower your cholesterol, and improve hormone levels related to obesity. This substance may also help lower your blood sugar by reducing how much carbs your body absorbs.
Losing weight with Ozempic can be a great way to jumpstart your health journey. But keeping the weight off can be a challenge for many people. While it takes commitment and lifestyle changes, maintaining weight loss after using Ozempic is possible.
Ozempic is only intended and approved for people with type 2 diabetes. You should not take it solely for weight loss. Doing so may prevent patients who require the medication for blood sugar management from getting it. Interrupting their treatment with Ozempic creates serious health risks.
Most patients use this pen to take 4 doses of the starting dose (0.25 mg) then 2 doses of the next highest dose (0.5 mg) before switching to a new pen. The pens for the 1mg and 2 mg doses of Ozempic each contain 4 doses.
Swelling/redness/itching at the injection site, tiredness, nausea, vomiting, diarrhea, or constipation may occur. Nausea usually lessens as you continue to use semaglutide. If any of these effects last or get worse, tell your doctor or pharmacist promptly.