Final Thoughts. As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
If you have a breeding dog, a pregnant dog, or a puppy between 6 and 8 weeks old, Heartgard Plus is the safest option. If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
Use with caution in dogs with a history of seizures or neurologic disorders. Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms.
Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 ...
Simparica Trio is a popular parasite treatment because it tackles many common dog parasites all in one go, including ticks and fleas, roundworms and hookworms, and even heartworm disease. Developed by Zoetis, Simparica Trio is just one possible option for parasite control and prevention across the market.
Trifexis is one of the leading oral combination heartworm preventatives. It is a once a month chewable tablet that prevents heartworms, kills adult fleas and also prevents hookworms, roundworms and whipworms. Sentinel Spectrum does the same, with the added benefit of preventing tapeworms.
Simparica Trio should be used with caution in dogs with a history of seizures. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders.
The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).
However, most dog parents will need to purchase a separate monthly preventative for heartworm and intestinal parasites. Simparica Trio might be more expensive when the two are side by side, but ultimately it is the better value.
Choosing between Simparica Trio and Trifexis
For pet parents on the hunt for an effective, safe, and reliable way to protect their pups against heartworms, fleas, hookworms, and roundworms, Trifexis and Simparica Trio are two incredible options.
While Simparica is focused on flea and tick prevention, alternatives like Bravecto, NexGard, and Trifexis offer additional coverage for heartworms and intestinal parasites. It's essential to consider your dog's needs and consult your veterinarian to choose the best option.
Simparica Trio is a chewable flavored tablet with a minimum label dosage of 1.2 mg/kg sarolaner, 5 mg/kg pyrantel (as pamoate salt) and 24 µg/kg moxidectin. Other licensed combination products contain the macrocylcic lactone (ML) ivermectin, moxidectin or milbemycin oxime for canine heartworm disease prevention.
Simparica TRIO is a tasty monthly chew that provides triple protection against a trio of the biggest threats facing our dogs. Fleas and ticks, intestinal worms and deadly heartworm.
That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years. For Credelio, six seizures were reported in the first six months after its approval. The manufacturers said the risk of side effects is rare, less than one in 10,000 doses sold.
Additionally, the chemicals in some flea treatments can be irritating to dogs, leading to discomfort and restlessness. Finally, some dogs may experience an allergic reaction to the ingredients in flea medicine, which can also lead to restlessness.
Seizures in dogs are common, but it does appear that the risk increases when using Nexgard, Bravecto and Simparica.
Abnormal neurologic signs such as tremors, decreased conscious proprioception, ataxia, decreased or absent menace, and/or seizures were reported in dogs receiving SIMPARICA (see Animal Safety).
I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation.
Bravecto Chew is also effective in killing adult fleas, so it can help reduce the risk of your dog getting flea bite dermatitis. If you're looking for a safe and effective flea and tick treatment for your dog, Bravecto Chew is the way to go.
#1 Heartgard Plus Soft Chews [Best Overall Heartworm Prevention for Dogs]: A long-trusted favorite by veterinarians, dog owners have howled its praises for years and continue to today.
Best Overall: Frontline Plus Topical Treatment
The most frequently recommended is a topical treatment. Frontline Plus is a well-established product: “For more than 20 years, veterinarians and pet owners have been using Frontline Plus for Dogs to effectively prevent, treat, and control fleas,” writes DogProductPicker.
Although there are fewer mosquitoes in the winter, there is still a risk that your pet could get heartworms if you stop giving heartworm prevention medication during this season. That's one reason veterinarians strongly recommend pets receive heartworm prevention medication year-round.